Prompt effect of replacing the 7-valent pneumococcal conjugate vaccine with the 13-valent vaccine on the epidemiology of invasive pneumococcal disease in Norway

Steens, Anneke; Bergsaker, Marianne A. Riise; Aaberge, Ingeborg S.; Rønning, Karin; Vestrheim, Didrik Frimann

doi:10.1016/j.vaccine.2013.10.032

Cited by 179 publications

(134 citation statements)

References 25 publications

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“…4,12,15 Following the introduction of the PCV vaccination program for children, the majority of PCV serotypes became rare in both children and adults due to a combination of immunity and herd protection. 4,7,15,18 In a study by Slotved et al, 12 it was shown that the incidence rate for 10 non-PCV serotypes showed an age-dependent difference. In general, the IPD incidence of these serotypes was low in the age groups 0-4 y and 5-64 years, while it was relatively high in the 65C years age group.…”

Section: What About Ppv-23 On the Ipd And Carriage?mentioning

confidence: 99%

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Other age groups than children need to be considered as carriers of Streptococcal pneumoniae serotypes

Slotved

2016

Human Vaccines & Immunotherapeutics

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We need to raise the issue that focus on children as the only carriage group for pneumococci is not optimal; we need to consider that other age groups might also be carriers of pneumococcal serotypes causing invasive pneumococcal diseases (IPD) in unvaccinated age groups. The pneumococcal conjugate vaccines (PCV) have successfully removed IPD from vaccinated children. Studies have shown an effect of PCV reducing the pneumococcal carriage of PCV serotypes in children. The status for several countries having used PCV for many years is that they do not see PCV serotypes neither carried nor as a cause of IPD in children.PCV vaccination of children has shown a herd protection effect in unvaccinated groups as a reduction in IPD cases caused by PCV serotypes. However, not all PCV serotypes have disappeared as the cause of IPD in the unvaccinated age groups. The author therefore believes that if we are to see PCV serotypes disappear as a cause of IPD in unvaccinated age groups, we need to perform further carriage studies to examine carriage in other age groups. Alternatively, all age groups should be vaccinated against pneumococci to eliminate IPD caused by PCV serotypes from possible hidden carriers.

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Section: What About Ppv-23 On the Ipd And Carriage?mentioning

confidence: 99%

“…15 Thus, the carriage study from Norway did not provide information on whether children are the main reservoir of these non-PCV serotypes (8, 12F, 20), or whether other age groups are more important.…”

Section: What About Ppv-23 On the Ipd And Carriage?mentioning

confidence: 99%

Other age groups than children need to be considered as carriers of Streptococcal pneumoniae serotypes

Slotved

2016

Human Vaccines & Immunotherapeutics

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“…Early results from other studies suggest that immunization of children with PCV13 might not affect rates of infections caused by serotype 3 in adults. 5,6 Therefore, immunization of adults with PCV13 might provide a mechanism for preventing disease caused by serotype 3 in adults.…”

Section: Some Encouraging Preliminarymentioning

confidence: 99%

Pneumococcal conjugate vaccines for adults

Shapiro

2014

Human Vaccines & Immunotherapeutics

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“…1 Since the introduction of PCVs in children, indirect protection of unvaccinated populations against invasive pneumococcal disease (IPD) has been clearly demonstrated. [3][4][5][6][7][8][9] Despite a partial replacement by non-vaccine types, these studies have revealed a relevant decrease in the overall pneumococcal disease burden in all age groups. One could calculate from IPD surveillance data that for every single directly prevented episode of IPD in vaccinated children, there are several additional IPD episodes prevented in the unvaccinated adult population, particularly in elderly.…”

Section: Introductionmentioning

confidence: 99%

Herd effects of child vaccination with pneumococcal conjugate vaccine against pneumococcal non-invasive community-acquired pneumonia: What is the evidence?

Werkhoven

2016

Human Vaccines & Immunotherapeutics

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Prompt effect of replacing the 7-valent pneumococcal conjugate vaccine with the 13-valent vaccine on the epidemiology of invasive pneumococcal disease in Norway

Cited by 179 publications

References 25 publications

Other age groups than children need to be considered as carriers of Streptococcal pneumoniae serotypes

Other age groups than children need to be considered as carriers of Streptococcal pneumoniae serotypes

Pneumococcal conjugate vaccines for adults

Herd effects of child vaccination with pneumococcal conjugate vaccine against pneumococcal non-invasive community-acquired pneumonia: What is the evidence?

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