Prompt-gamma compensation in Rb-82 myocardial perfusion 3D PET/CT

Esteves, Fábio; Nye, Jonathan A.; Khan, Adnan Umar; Folks, Russell; Halkar, Raghuveer; Garcia, Ernest; Schuster, David M.; Raggi, Paolo; Votaw, John R.

doi:10.1007/s12350-009-9170-1

Cited by 50 publications

(22 citation statements)

References 16 publications

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“…The difficulties with Rb-82 may be related to the fact that resolution recovery and TOF techniques have been primarily developed for different tracers, and Rb-82 requires special considerations due to longer positron path and the need for prompt gamma correction. 19 Thus, a separate evaluation will be required to test the application of the new reconstruction methods for dynamic blood flow quantification with Rb-82.…”

Section: Rubidium-82mentioning

confidence: 99%

How to reconstruct dynamic cardiac PET data?

Slomka

Alessio

Germano

2017

Journal of Nuclear Cardiology

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Section: Rubidium-82mentioning

confidence: 99%

How to reconstruct dynamic cardiac PET data?

Slomka

Alessio

Germano

2017

Journal of Nuclear Cardiology

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“…Specifically for cardiac applications, current PET scanners have been optimized to cope with high count levels in first-pass 82 Rb imaging for myocardial blood flow measurements 67 and with additional 82 Rb γ-prompt decays affecting 3D imaging. 68 The system sensitivity of 3D PET scanners is 4× to 6× higher than scanners operating in 2D mode. 69 Further technical advances include developments of photon time-offlight methods 70 and new high-definition iterative reconstruction techniques based on scanner-specific 3D modeling of system resolution with effective tomographic resolution as low as 2 mm.…”

Section: Technical Advancesmentioning

confidence: 99%

Achieving Very-Low-Dose Radiation Exposure in Cardiac Computed Tomography, Single-Photon Emission Computed Tomography, and Positron Emission Tomography

Dey

Slomka

Berman

2014

Circ: Cardiovascular Imaging

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“…2 Furthermore, until recently, the interference of prompt gamma emission during 82 Rb decay with scatter correction on 3D systems was not fully recognized. 3 Most literature in cardiac PET imaging describes studies performed in 2D mode. 4 However, currently the users of new PET/CT equipment are unable to acquire images in 2D since almost all new scanners operate in 3D mode only and come without septa.…”

Section: D Pet Technologymentioning

confidence: 99%

Low-dose 3D 82Rb PET

Slomka

Berman

Germano

2012

Journal of Nuclear Cardiology

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3D PET TECHNOLOGY3D PET systems were introduced for oncological imaging almost a decade ago and are now universally used. The principal advantage of the 3D PET acquisition (accepting photons from all angles) over the 2D PET with parallel septa is much higher sensitivity (4-6 times) for photon detection, albeit at the cost of increased scatter fraction and more complex image reconstruction. 1 3D 82 Rb PET acquisition has presented image quality problems due to increased random events when previous generation 2D-3D BGO scanners were used. 2 Furthermore, until recently, the interference of prompt gamma emission during 82 Rb decay with scatter correction on 3D systems was not fully recognized. 3 Most literature in cardiac PET imaging describes studies performed in 2D mode. 4 However, currently the users of new PET/CT equipment are unable to acquire images in 2D since almost all new scanners operate in 3D mode only and come without septa. Therefore, the optimal use of such 3D PET/CT for cardiac imaging and in particular for 82 Rb imaging is of great interest to the nuclear cardiology community. IMPORTANCE OF LOW-DOSE PETThe increased sensitivity of the new 3D PET/CT systems can be utilized to reduce radiation exposure to the patient during the myocardial perfusion imaging scan. Although the true effect of radiation exposures lower than 100 mSv on cancer risk is unknown as the risk estimates are extrapolated linearly from higher doses, 5,6 radiation exposure and discussion of cardiac imaging's contribution to hypothetical (but possible) cancer have been recently highlighted. Therefore, from the patient's perspective, radiation exposure ''as low as reasonably achievable'' is very desirable. ARTICLEThe accuracy of low-dose 3D PET/CT for detecting coronary artery disease (CAD) was assessed in an article by Kaster et al in this issue of the Journal of Nuclear Cardiology. 7 The authors evaluated a total of 70 patients with coronary angiography correlation and 77 patients with low likelihood (LLk) of CAD to assess the diagnostic accuracy of low-dose 3D 82 Rb-PET (weight-dependent 10 MBq/kg, translating from the SI units for the US audience, approximately 0.12 mCi/lb). Automatic relative quantification (with automatically derived summed stress scores) and quantification of transient ischemic dilation (TID) were used, without absolute flow measurements and without visual reading by the physicians. They report that by automated analysis they achieved perfect sensitivity (100%) and 48% specificity for the detection of obstructive stenosis in the angiographic group. The specificity improved to 78% without sensitivity loss in a subgroup (n = 45) excluding patients with acute myocardial infarction and low ejection fraction. It should be noted that to achieve 100% sensitivity, the authors modify perfusion abnormality thresholds depending on the TID variable. The sensitivity was 95% by perfusion analysis alone. The receiver operator characteristics areas under-curve (ROC-AUC) ranged from 0.92 to 0.97. As expected with relative perfu...

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Prompt-gamma compensation in Rb-82 myocardial perfusion 3D PET/CT

Abstract: PGC in Rb-82 3D PET improves the specificity for obstructive CAD at coronary angiography with no significant loss in sensitivity.

Cited by 50 publications

References 16 publications

How to reconstruct dynamic cardiac PET data?

How to reconstruct dynamic cardiac PET data?

Achieving Very-Low-Dose Radiation Exposure in Cardiac Computed Tomography, Single-Photon Emission Computed Tomography, and Positron Emission Tomography

Low-dose 3D 82Rb PET

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