Prompt gamma neutron activation analysis of 10B and Gd in biological samples at the MEPhI reactor

Khokhlov, V.F.; Zaitsev, K. N.; Beliayev, V.N.; Kulakov, V. N.; Липенгольц, А. А.; Portnov, A. A.

doi:10.1016/j.apradiso.2009.03.082

Cited by 7 publications

(3 citation statements)

References 4 publications

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“…With the improvement of the relevant equipment of PGRA by using the monochromatic neutron beam, the detection limit of this new PGRA facility is 0.3 μg of 10 B. It can measure 1 mg of 10 B within a 10% error …”

Section: Analytical Methods In Biological Samplesmentioning

confidence: 99%

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The Development of Boron Analysis and Imaging in Boron Neutron Capture Therapy (BNCT)

et al. 2022

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Boron neutron capture therapy (BNCT) is a selective biological targeted nuclide technique for cancer therapy. It has the following attractive features: good targeting, high effectiveness, and causes slight damage to surrounding healthy tissue compared with other traditional methods. It has been considered as one of the promising methods for the treatment of various cancers. Measuring 10B concentrations is vital for BNCT. However, the existing technology and equipment cannot satisfy the real-time and accurate measurement requirements, and more efficient methods are in demand. The development of methods and imaging applied in BNCT to help measure boron concentration is described in this review.

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Section: Analytical Methods In Biological Samplesmentioning

confidence: 99%

“…It can measure 1 mg of 10 B within a 10% error. 53 This method had improvements and advantages compared to the previous technologies. For example, it is independent of the chemical form of boron and the pretreatment of the sample.…”

Section: Analytical Methods In Biological Samplesmentioning

confidence: 99%

The Development of Boron Analysis and Imaging in Boron Neutron Capture Therapy (BNCT)

et al. 2022

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“…Here, we introduce grazing-incidence neutron-induced fluorescence (GINF), a method to probe the interfacial density of labeled molecules at solid/liquid interfaces with an evanescent neutron wave. The method is based on the prompt emission of γ radiation after neutron capture, a principle that has been successfully applied by Zhang et al to study thin solid films in neutron standing-wave experiments. , But despite medical applications for the detection of chemical elements in tissues, , neutron-induced γ radiation has so far not been used to probe dilute layers of labeled molecules in aqueous environments. GINF utilizes an evanescent neutron wave near a solid/liquid interface to induce the characteristic γ-fluorescence of the nuclide label.…”

Section: Introductionmentioning

confidence: 99%

Grazing-Incidence Neutron-Induced Fluorescence Probes Density Profiles of Labeled Molecules at Solid/Liquid Interfaces

et al. 2013

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We report on the use of characteristic prompt γ-fluorescence after neutron capture induced by an evanescent neutron wave to probe densities and depth profiles of labeled molecules at solid/liquid interfaces. In contrast to classical scattering techniques and X-ray fluorescence, this method of "grazing-incidence neutron-induced fluorescence" combines direct chemical specificity, provided by the label, with sensitivity to the interface, inherent to the evanescent wave. We demonstrate that the formation of a supported lipid membrane can be quantitatively monitored from the characteristic fluorescence of (157)Gd(3+) ions bound to the headgroup of chelator lipids. Moreover, we were able to localize the (157)Gd(3+) ions along the surface normal with nanometer precision. This first proof of principle with a well-defined model system suggests that the method has a great potential for biology and soft matter studies where spatial resolution and chemical sensitivity are required.

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Monte Carlo simulation of PGNAA system for determining element content in the rock sample

Zhang

Liu

2013

J Radioanal Nucl Chem

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Prompt gamma neutron activation analysis of 10B and Gd in biological samples at the MEPhI reactor

Cited by 7 publications

References 4 publications

The Development of Boron Analysis and Imaging in Boron Neutron Capture Therapy (BNCT)

The Development of Boron Analysis and Imaging in Boron Neutron Capture Therapy (BNCT)

Grazing-Incidence Neutron-Induced Fluorescence Probes Density Profiles of Labeled Molecules at Solid/Liquid Interfaces

Monte Carlo simulation of PGNAA system for determining element content in the rock sample

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