Prompt increases in retinol-binding protein 4 and endothelial progenitor cells during acute exercise load in diabetic subjects

Aoki, Atsushi; Murata, Miho; Asano, Tomoko; Ikoma, Aki; Sasaki, Masami; Saito, T.; Otani, Taeko; Jinbo, Sachimi; Ikeda, Nahoko; Kawakami, Masanobu; Ishikawa, San‐e

doi:10.1507/endocrj.ej12-0192

Cited by 6 publications

(3 citation statements)

References 22 publications

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“…There are several trials dealing with the effect of exercise on EPC biology in diabetic patients. Acute exercise loads promptly increased the EPC (CD34+/CD133+) count in patients with type 2 diabetes with and without nephropathy [102]. In patients with type 2 diabetes and diagnosed coronary artery disease, an elevated level of microparticles and EPC could be detected.…”

Section: Lifestyle Modificationmentioning

confidence: 92%

The Impact of Modern Anti-Diabetic Treatment on Endothelial Progenitor Cells

Altabas,

Marinković Radošević,

Špoljarec

et al. 2023

Biomedicines

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Diabetes is one of the leading chronic diseases globally with a significant impact on mortality. This condition is associated with chronic microvascular and macrovascular complications caused by vascular damage. Recently, endothelial progenitor cells (EPCs) raised interest due to their regenerative properties. EPCs are mononuclear cells that are derived from different tissues. Circulating EPCs contribute to regenerating the vessel’s intima and restoring vascular function. The ability of EPCs to repair vascular damage depends on their number and functionality. Diabetic patients have a decreased circulating EPC count and impaired EPC function. This may at least partially explain the increased risk of diabetic complications, including the increased cardiovascular risk in these patients. Recent studies have confirmed that many currently available drugs with proven cardiovascular benefits have beneficial effects on EPC count and function. Among these drugs are also medications used to treat different types of diabetes. This manuscript aims to critically review currently available evidence about the ways anti-diabetic treatment affects EPC biology and to provide a broader context considering cardiovascular complications. The therapies that will be discussed include lifestyle adjustments, metformin, sulphonylureas, gut glucosidase inhibitors, thiazolidinediones, dipeptidyl peptidase 4 inhibitors, glucagon-like peptide 1 receptor analogs, sodium-glucose transporter 2 inhibitors, and insulin.

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Section: Lifestyle Modificationmentioning

confidence: 92%

The Impact of Modern Anti-Diabetic Treatment on Endothelial Progenitor Cells

Altabas,

Marinković Radošević,

Špoljarec

et al. 2023

Biomedicines

View full text Add to dashboard Cite

show abstract

“…An interesting approach for evaluation of vascular function might be the determination of the EPCs level. Although the potential of acute (sub-maximal) exercise to stimulate and mobilize the EPCs has been shown to be blunted in T2DM patients as compared to healthy controls [65], Aoki et al [86] have proven an increment of EPCs during acute exercise load in diabetic patients, which seems an additional promising beneficial effect of exercise [65]. A recent study, however, by Waclawovsky et al failed to show an increase of EPCs after an acute combined, aerobic and resistance training (ART) session in young T1DM patients in spite of increased response to postocclusive reactive hyperaemia (PORH), assessed by venous occlusion plethysmography [87].…”

Section: Impact Of Acute Exercise In Diabetic Microcirculationmentioning

confidence: 99%

Assessing the evidence: Exploring the effects of exercise on diabetic microcirculation

Lenasi

Klonizakis

2017

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Diabetes mellitus (DM) is associated with cardiovascular complications. Impairment of glycemic control induces noxious glycations, an increase in oxydative stress and dearangement of various metabolic pathways. DM leads to dysfunction of micro- and macrovessels, connected to metabolic, endothelial and autonomic nervous system. Thus, assessing vascular reactivity might be one of the clinical tools to evaluate the impact of harmful effects of DM and potential benefit of treatment; skin and skeletal muscle microcirculation have usually been tested. Physical exercise improves vascular dysfunction through various mechanisms, and is regarded as an additional effective treatment strategy of DM as it positively impacts glycemic control, improves insulin sensitivity and glucose uptake in the target tissues, thus affecting glucose and lipid metabolism, and increases the endothelium dependent vasodilation. Yet, not all patients respond in the same way so titrating the exercise type individualy would be desirable. Resistance training has, apart from aerobic one, been shown to positively correlate to glycemic control, and improve vascular reactivity. It has been prescribed in various forms or in combination with aerobic training. This review would assess the impact of different modes of exercise, the mechanisms involved, and its potential positive and negative effects on treating patients with Type I and Type II DM, focusing on the recent literature.

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“…52 Augmenting Mobilization and Migration: Role of Stromal Derived Factor-1 (SDF-1) SDF-1 is a chemokine for EPCs that, while constitutively expressed in the bone marrow, is also induced in peripheral tissues in the setting of ischemia by HIF-1 dependent mechanisms. 53 EPCs express the cell surface receptor for SDF-1, CXCR4, allowing these cells to egress from the bone marrow and migrate along an SDF-1 gradient to initiate and support angiogenesis in areas of ischemia.…”

Section: Indirect Strategies To Augment Epc Numbermentioning

confidence: 99%

Endothelial Loss and Repair in the Vascular Complications of Diabetes

Gilbert

2013

Circ J

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Prompt increases in retinol-binding protein 4 and endothelial progenitor cells during acute exercise load in diabetic subjects

Cited by 6 publications

References 22 publications

The Impact of Modern Anti-Diabetic Treatment on Endothelial Progenitor Cells

The Impact of Modern Anti-Diabetic Treatment on Endothelial Progenitor Cells

Assessing the evidence: Exploring the effects of exercise on diabetic microcirculation

Endothelial Loss and Repair in the Vascular Complications of Diabetes

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