Advances in neurobiology, including brain-scanning and physiological measurements, can now be applied to enhance our understanding of reduced self-awareness, one of fl ow's core symptoms. It throws light on optimal experience, since self-forgetting links to fl ow's positive affect, a paradox in such a highly selfaware species. This chapter synthesises empirical studies into self-awareness, and how it is down-regulated during task performance. A breakthrough was the identification of a specifi c neuronal network for self-awareness, discovered during brain mapping of goal-directed tasks. The network becomes active whenever tasks end, rather like a default. Evidence suggests that deep engagement in skilled (fl ow-like) activities dampens the network, relating somewhat to earlier concepts of hypofrontality. An occupational science perspective proposes that participation in complex activities may reduce the weight of our extreme self-awareness. The human propensity to 'occupy' ourselves through a range of activities, such as the arts, can be a major mechanism for stress-reduction. Early twentieth century observations of the restorative function of being occupied transformed into the profession of occupational therapy, arguably originally a kind of 'fl ow therapy'.