Proniosome based transdermal delivery of levonorgestrel for effective contraception

Vora, Bhavana; Khopade, A. J.; Jain, Neeraj

doi:10.1016/s0168-3659(97)00100-4

Cited by 250 publications

(172 citation statements)

References 23 publications

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“…Further addition of water resulted in swelling of the lipid bilayer due to interaction of water with polar groups of surfactants and above a limiting concentration of solvent, the bilayers formed spherical structures randomly giving rise to vesicular structures. 14,21 Morphological characterization of the protransfersomes as well as existence of their vesicular structure after hydration was confirmed by TEM ( Figure 2). Entrapment efficiency of the PTG formulation was high (maximum 96.9 ± 0.4 for PTDF-I 3 ) because of the lipophilic nature of the drug.…”

Section: Preparation and In Vitro Characterization Of Formulationsmentioning

confidence: 85%

“…This result was consistent with the entrapment efficiency of levonorgestrel in proniosome formulation as reported in previous publication. 14 …”

Section: Preparation and In Vitro Characterization Of Formulationsmentioning

confidence: 99%

“…14 In the present study the provesicular approach has been extended to the transfersomes, which are reported to have superior skin penetration ability. Liquid crystalline protransfersome gel (PTG) will be converted into the ultraflexible vesicles, transfersomes also known as elastic liposomes, in situ by absorbing water.…”

Section: Introductionmentioning

confidence: 97%

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Proultraflexible lipid vesicles for effective transdermal delivery of levonorgestrel: Development, characterization, and performance evaluation

et al. 2005

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The present investigation aimed at formulation, performance evaluation, and stability studies of new vesicular drug carrier system protransfersomes for transdermal delivery of the contraceptive agent, levonorgestrel. Protransfersome gel (PTG) formulations of levonorgestrel were prepared and characterized for vesicle shape, size, entrapment efficiency, turbidity, and drug permeation across rat skin and were evaluated for their stability. The system was evaluated in vivo for biological assay of progestational activity including endometrial assay, inhibition of the formation of corpora lutea, and weight gain of uterus. The effects of different formulation variables (type of alcohol, type and concentration of surfactant) on transdermal permeability profile were assessed. The optimized PTG formulation showed enhanced in vitro skin permeation flux of 15.82 ± 0.37 μg/cm 2 /hr as compared to 0.032 ± 0.01 μg/cm 2 /hr for plain drug solution. PTG also showed good stability and after 2 months of storage there was no change in liquid crystalline nature, drug content, and other characteristic parameters. The peak plasma concentration of levonorgestrel (0.139 ± 0.05 μg/mL) was achieved within 4 hours and maintained until 48 hours by a single topical application of optimized PTG formulation. In vivo performance of the PTG formulation showed increase in the therapeutic efficacy of drug. Results indicated that the optimized protransfersomal formulation of levonorgestrel had better skin permeation potential, sustained release characteristic, and better stability than proliposomal formulation.

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Section: Preparation and In Vitro Characterization Of Formulationsmentioning

confidence: 85%

“…This result was consistent with the entrapment efficiency of levonorgestrel in proniosome formulation as reported in previous publication. 14 …”

Section: Preparation and In Vitro Characterization Of Formulationsmentioning

confidence: 99%

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Proultraflexible lipid vesicles for effective transdermal delivery of levonorgestrel: Development, characterization, and performance evaluation

et al. 2005

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“…Suspend an accurately measured amount of drug niosomal formulation in 1ml phosphate buffer saline and transferred to a glass tube covered at its lower end by a soaked cellulose membrane [12] Drug delivery particle, an "immunoniosome" has been successfully synthesized and demonstrated the use of particle to target a specific site important in the inflammatory process, both in static cell culture and under flow [13] III. …”

Section: Related Workmentioning

confidence: 99%

To Study the Formulation of Niosome of Ofloxacin and Its Evaluation for Efficacy of Anti-Microbial Activity

Srivastav¹,

Das²

2014

IJIRSET

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Nanotechnology has offered enormous improvement in field of therapeutics by means of designing of nano-carriers that can cross biological barriers and are able to target cellular reservoirs. The aim of the present investigation was to formulate and evaluate Niosomes, a synthetic microscopic non-ionic surfactant vesicles formed on the admixture of a non-ionic surfactant, cholesterol and phosphate with subsequent hydration in aqueous media. The delivery of drugs by "vesicular drug delivery system" such as niosomes provides several important advantages over conventional drug therapy. Ofloxacin was selected as a suitable drug for the present study because it is a potent secondgeneration fluoroquinolone active against a broad range of gram positive and gram-negative aerobic and anaerobic bacteria. In the present investigation three formulations of Niosomal drug delivery system of ofloxacin with non ionic surfactant, span 60, in various proportions were prepared and evaluated for Morphological characterization, Encapsulation efficiency, In-vitro drug release study. The Ofloxacin niosomes were prepared by lipid film hydration method. The prepared ofloxacin niosomes showed a vesicle size of 100-300 nm, the entrapment efficiency was 78.4%. The partition coefficient value of ofloxacin was found to be 0.5.

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“…생체 이용율 촉진 시스템 중의 하나인 liposome은 피부 투과뿐만 아니라 물, 산소, 빛 등에 의해 쉽게 산화되는 불안 정한 물질을 안정화시키고 liposome에 포집된 물질의 방출 속도를 필요에 따라 조절하는 기능으로 인하여 의약, 화장품, 식품 등에 널리 이용되어 왔으나 [2][3][4][5] 산화적 분해가 일어나 기 쉽고 고가이며 정제가 어려운 단점이 있다 [6,7]. 이러한 liposome의 단점을 보완하고 피부 투과율을 높 이기 위해 기존의 liposome을 변형한 새로운 형태의 vesicles 개발이 이어졌는데 vesicles 막이 겔 상태보다 liquid 상태 에서의 피부 각질층을 더욱 잘 투과할 수 있는 점을 고려해 서 더 유연하면서 탄력적으로 변형이 쉬운 상태의 vesicles 을 만들려는 시도가 이루어졌다 [8][9][10][11].…”

Section: 경제성장 외모에 대한 관심의 증가 환경오염에 인한 복합 적인 요인으로 피부 트러블에 대한 관심이 증가하고unclassified

Development of Bioavailability Enhancement System for the Skin Permeation Promotion of Psolarea corylifolia Extract

조영호¹,

안계환²,

양승원³

et al. 2011

KSBB Journal

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1) Psolarea corylifolia extract that contains bakuchiol is known to have anti-microbial, anti-inflammatory and anti-scarring effects. In this study, a vesicles such as liposome, niosome, and transfersome were produced to encapsulate P. corylifolia extract and measured their stability and physiochemical property. The skin permeation and partitioning of P. corylifolia extract in the vesicles were elucidated in nude mouse skin by using Franz diffusion cells after topical application for 24 h. After storage at 25, 40, 70℃, and light, the stability of bakuchiol incorporated into the vesicles was maintained for 30 days. The optimal concentration of P. corylifolia extract entrapped into the vesicles was found to be 5~10%. From the physicochemical studies, after storage at 4, 25, and 40℃, the viscosity and particle size of the vesicles remained in 30~80 cP and the nanosize range for 6 months, respectively. From the permeation experiments, niosome showed a higher amount of bakuchiol permeated through the mouse skin compared to liposome and transfersome after 24 h. From these results, niosome and transfersome could be a good bioavailability enhancement system (BAES) for P. corylifolia extract to improve the skin permeation and

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Proniosome based transdermal delivery of levonorgestrel for effective contraception

Cited by 250 publications

References 23 publications

Proultraflexible lipid vesicles for effective transdermal delivery of levonorgestrel: Development, characterization, and performance evaluation

Proultraflexible lipid vesicles for effective transdermal delivery of levonorgestrel: Development, characterization, and performance evaluation

To Study the Formulation of Niosome of Ofloxacin and Its Evaluation for Efficacy of Anti-Microbial Activity

Development of Bioavailability Enhancement System for the Skin Permeation Promotion of Psolarea corylifolia Extract

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