“…For example, a nitrophenyl ester-based charge transfer monomer was used in addition to covalent imprinting with boronic ester dimethylaminostyrene. 352 Through the development of thin coatings of polymers on silica matrices 760 and study of factors such as temperature 994 further important insights regarding polymer performance were gained. The slow binding and rebinding kinetics traditionally associated with covalent molecularly imprinted polymers systems has been addressed in a number of studies 335,995 where the kinetics of template binding and rebinding in D-and L-phenyl mannoside derivative imprinted polymers was improved through the use of basic eluents.…”
Over 1450 references to original papers, reviews and monographs have herein been collected to document the development of molecular imprinting science and technology from the serendipitous discovery of Polyakov in 1931 to recent attempts to implement and understand the principles underlying the technique and its use in a range of application areas. In the presentation of the assembled references, a section presenting reviews and monographs covering the area is followed by papers dealing with fundamental aspects of molecular imprinting and the development of novel polymer formats. Thereafter, literature describing attempts to apply these polymeric materials to a range of application areas is presented.
“…For example, a nitrophenyl ester-based charge transfer monomer was used in addition to covalent imprinting with boronic ester dimethylaminostyrene. 352 Through the development of thin coatings of polymers on silica matrices 760 and study of factors such as temperature 994 further important insights regarding polymer performance were gained. The slow binding and rebinding kinetics traditionally associated with covalent molecularly imprinted polymers systems has been addressed in a number of studies 335,995 where the kinetics of template binding and rebinding in D-and L-phenyl mannoside derivative imprinted polymers was improved through the use of basic eluents.…”
Over 1450 references to original papers, reviews and monographs have herein been collected to document the development of molecular imprinting science and technology from the serendipitous discovery of Polyakov in 1931 to recent attempts to implement and understand the principles underlying the technique and its use in a range of application areas. In the presentation of the assembled references, a section presenting reviews and monographs covering the area is followed by papers dealing with fundamental aspects of molecular imprinting and the development of novel polymer formats. Thereafter, literature describing attempts to apply these polymeric materials to a range of application areas is presented.
“…After extensive optimization of the procedure, α-values between 3.5 and 6.0 were obtained. The selectivity in a chromatographic procedure is also high (separation factors up to α = 4.6) and, at higher temperature with gradient elution, resolution values of R s = 4.2 with baseline separation have been obtained. ,, 5 Schematic Representation of a Cavity Obtained by Polymerization of 1 a (adapted from refs and ) a The template 2 can be removed from (a) with water or methanol to give (b). Solvation of the functional groups leads to swelling of the cavity (c).…”
Section: Some Basic Considerations On Molecular
Imprinting In Polymer...mentioning
confidence: 99%
“…The selectivity in a chromatographic procedure is also high (separation factors up to R ) 4.6) and, at higher temperature with gradient elution, resolution values of R s ) 4.2 with baseline separation have been obtained. 41,61,62 The optimization of the racemic resolution procedure produced a number of interesting results. Even though they concern primarily the selectivity in binding studies, certain aspects are also important for catalysis.…”
Section: A An Example Of Covalent Imprintingmentioning
I. Introduction 1 II. Some Basic Considerations on Molecular Imprinting in Polymeric Materials for the Preparation of Catalysts 4 A. An Example of Covalent Imprinting 4 B. Optimization of the Polymer Structure 5 C. Binding Site Interactions 5 III. Preparation of Catalysts by Imprinting in Synthetic Polymers 8 A. Imprinting with the Product or an Analogue of the Reaction Product (Microreactors) 8 B. Imprinting with a Transition State Analogue (TSA) of the Ester Hydrolysis 9 1. General 9 2. Metal-Coordination during the Imprinting Procedure 9 3. Noncovalent Interaction during the Imprinting Procedure 10 4. Covalent Interaction during the Imprinting Procedure 10 5. Stoichiometric Noncovalent Interaction during the Imprinting Procedure 11 C. Catalysis of Elimination Reactions 14 D. Catalysis of Carbon−Carbon Bond Formation 15 E. Catalysis of Oxidation and Hydrogen Transfer 16 IV. Catalysis with Imprinted Silicas and Zeolites 17 A. "Footprint" Catalysis 17 B. Other Examples for Catalytically Active Imprinted Silicas 18 C. Imprinting in Zeolites 19 V. Bioimprinting 19 VI. Concluding RemarkssA Critical Discussion 21 A. The Problem of Controls in Kinetic Measurements 21 B. The Influence of the Cross-Linking Degree 23 C. The Influence of the Type of Dispersion 23 D. "Polyclonality" of the Active Sites 24 E. Future Prospects in Catalysis 24 VII. Acknowledgments 25 VIII. References 25
“…The positive effect of increased temperature has been explained previously in terms of a general improvement in mass transfer kinetics, 12 and disproportional changes in the numbers of theoretical plates observed for two enantiomers at increased temperature. 13 Alternatively, we can assume that, with a subsequent increase in temperature, the thermal extension of the polymer approaches the level that existed during polymerization. As a result, the size and structure of the binding cavities should resemble more…”
Section: Separation Of Ephedrine Enantiomers With Mipsmentioning
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