The evolution of the mechanism of human behavior formation analysis has significantly influenced the development of human reliability analysis (HRA), which aims to calculate human error probability (HEP) with performance shaping factors (PSFs). This paper reviews the typical HRA methods in different generations, the role of PSFs, and their interrelation‐ships in human risk modeling, with the background of nuclear power plants (NPPs). In a retrospective of typical HRA methods, PSF plays a fundamental role in assessing human performance during task operation. However, the subjectivity in defining and evaluating PSFs often leads to a partial representation of human behavior characteristics and human risk evolution, resulting in the neglect of PSF inter‐relationships and conservative HEP estimation. Recent studies have emphasized employing simulation platforms to simulate the task process and obtain data relevant to PSFs that can enable the exploration of the mutual effects to support the calculation of HEP more accurately. Compared to certain previous methods involving over‐simplification and inappropriate assumptions resulting in inaccurate results, current HRA methods are prone to the construction of HEP models based on objective data acquisition and dynamic calculations with process models. This shift enables a better illustration of the intricate relationships among PSFs. Reflecting on the current trend of HRA methodology, this paper proposes a possible PSF quantification based on physiological measurement providing accessible and objective data. It improves the shortcomings in data scarcity and time‐invariance of HEP calculation, thus more accurately and realistically responds to the accumulation and fluctuation of human risks throughout a task.