2019
DOI: 10.1101/734368
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Proof-of-concept for the detection of early osteoarthritis pathology by endomicroscopy

Abstract: †shared last authorship. One Sentence Summary:We report a correlation between articular cartilage surface nanoscale stiffness and chondrocyte spatial organization; using this correlation enables early pathology detection by currently available clinical optical methods. Abstract:Osteoarthritis (OA) is a degenerative joint disease and the leading cause of global disability.Clinical trials to date have been unable to pinpoint early and potentially reversible disease states with current clinical technology and hen… Show more

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