Proof-of-Concept Prototype for Noninvasive Intracranial Pressure Monitoring Using Ocular Hemodynamics Under Applied Force

Abstract

Studies have suggested that elevated cerebrospinal fluid (CSF) pressure can have a damaging effect on the optic nerve and visual acuity. There is need for a noninvasive CSF pressure measurement technique. A portable device for noninvasive intracranial pressure (ICP) monitoring would have a significant impact on clinical care. A proof-of-concept prototype is used to test the feasibility of a technique for monitoring ICP changes. The proposed methodology utilizes transcranial Doppler ultrasonography to monitor blood flow through the ophthalmic and central retinal arteries while forces are applied to the cornea by a controlled actuator. Control algorithms for the device were developed and tested using an integrated experimental platform. Preliminary results using tissue-mimicking materials show the ability to differentiate between materials of differing stiffness that simulates different levels of ICP. These experiments are an initial step toward a handheld noninvasive ICP monitoring device.

Association of Cavum Septum Pellucidum and Cavum Vergae With Cognition, Mood, and Brain Volumes in Professional Fighters

“…The development of devices designed to monitor intracranial pressure in real time could help elucidate this theory. 36 Another potential mechanism for the development of CSP and CV is the accumulation of various proteins in the subarachnoid space owing to a breakdown of the blood-brain barrier, resulting in impaired cerebrospinal fluid resorption. 37 Finally, ex vacuo expansion of the potential space in the septum pellucidum from central volume loss could also exacerbate CSP enlargement in cases of repetitive traumatic injury.…”

“…Subsequently, transient increased intracranial pressure, perhaps from direct trauma or Valsalva maneuvers when the fighter bears down before or during contact, may accentuate these tears and/or cause increased cerebrospinal fluid to accumulate. The development of devices designed to monitor intracranial pressure in real time could help elucidate this theory . Another potential mechanism for the development of CSP and CV is the accumulation of various proteins in the subarachnoid space owing to a breakdown of the blood-brain barrier, resulting in impaired cerebrospinal fluid resorption .…”