Proopiomelanocortin peptides are potent modulators of human IgE synthesis

Aebischer, Iwan; Schauer, E.; Schwarz, Andreas; Schwarz, Thomas L.; Stadler, B.M.; Luger, T A

doi:10.1016/0923-1811(93)90783-l

Cited by 2 publications

(6 citation statements)

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“…Moreover, aMSH reversed the depressive influences of IL-I or TNFa on the effector phase of contact hypersensitivity in animals (26). There is even more evidence for the immunomodulatory ability of POMC-derived peptides, because it was shown that aMSH inhibits the production of IFN'y by PBMC (27). In contrast, the synthesis of IL-IO was found to be upregulated by aMSH (28), and both aMSH as well as ACTH seem to be able to modulate IL-4-and anti-CD40-driven release of IgE by PBMC.…”

Section: Discussionmentioning

confidence: 99%

“…In contrast, the synthesis of IL-IO was found to be upregulated by aMSH (28), and both aMSH as well as ACTH seem to be able to modulate IL-4-and anti-CD40-driven release of IgE by PBMC. ACTH at physiological concentrations increased IgE synthesis, whereas higher doses of ACTH strongly inhibited IgE synthesis by PBMC (27). Therefore, POMC peptides may play a role in the pathogenesis of allergic diseases and may represent the postulated neuroendocrine arm in diseases such as atopic dermatitis.…”

Section: Discussionmentioning

confidence: 99%

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Proopiomelanocortin-derived peptides are synthesized and released by human keratinocytes.

Schauer¹,

Trautinger²,

Köck³

et al. 1994

J. Clin. Invest.

337

278

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Proopiomelanocortin-derived peptides are synthesized and released by human keratinocytes.

Schauer¹,

Trautinger²,

Köck³

et al. 1994

J. Clin. Invest.

337

278

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“…Motionuclear cells ttotn normal healthy human donors were isolated from heparinized venous blood and cultuted in complete IMDM (13). PMBC wctc cultuted in TC 24 wells (Falcon 3047, Becton Dickinson GmbH, Heidelberg, Germany), in 96 well flat bottom (Falcon 3072) or in 96 well LI bottom (Falcon 3077) microtitcr plates.…”

Section: Cell Preparation and Eiillure Conditionsmentioning

confidence: 99%

“…IgE measurements were carried out as pteviously described (13). IgG, IgA and IgM were determined with a standard ELISA using anti-IgG, anti-lgA or Anti-lgM catching antibodies (The Binding Site, Nos.…”

Section: Igf Igg Iga and Igm Measurementmentioning

confidence: 99%

“…We tecently demonstrated that the atnount of IgE synthesized in vitro can be altered by the addition of neuroendoerine peptides such as ACTH, alpha tiielanoeyte stitnulating hortnone (a-MSH) or corticotropin releasing factor (13). These neuropeptides govern in vivo the activation of the hypothalatnic pituitary adrenal axis leading finally to the release of glucocorticoids stoted in the adrenal glands.…”

mentioning

confidence: 99%

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Neuropeptides accentuate interleukin‐4 induced human immunoglobuline E synthesis in vitro

Aebischer

Stämpfli

Miescher

et al. 1996

Experimental Dermatology

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Corticotropin releasing factor, adrenocorticotropic hormone (ACTH) and alpha-melanocyte stimulating hormone either inhibit or enhance in a dose-dependent fashion an interleukin-4 (IL-4) driven human IgE synthesis in vitro. Here, we show that culture conditions strongly influence the earlier observed dose- and donor-dependent effects of adrenocorticotropic hormone. The effect of ACTH on IgE synthesis became only apparent late during culture periods, suggesting an indirect effect via the cellular microenvironment rather than by acting directly at the level of B-cell isotype switching. Thus, we studied other proopiomelanocortin (POMC) derived peptides and neuropeptides known to influence the cellular microenvironment. Indeed, similar modulatory effects on IgE synthesis were also observed by the addition of other proopiomelanocortin-derived peptides such as alpha-, beta-, and gamma-endorphins as well as by the opioid binding pentapeptide Leu-enkephalin. Furthermore the neuropeptide substance P accentuated an IL-4 or an IL-4 and anti-CD40 antibody driven class switch to IgE. In contrast to ACTH, substance P interfered not only with IgE synthesis but also with the synthesis of the other immunoglobulin isotypes. Thus, systemically acting neuroendocrine peptides such as ACTH and locally acting neuropeptides such as the enkephalins and substance P can modulate the magnitude of an IL-4 induced IgE response.

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Proopiomelanocortin peptides are potent modulators of human IgE synthesis

Cited by 2 publications

References 0 publications

Proopiomelanocortin-derived peptides are synthesized and released by human keratinocytes.

Proopiomelanocortin-derived peptides are synthesized and released by human keratinocytes.

Neuropeptides accentuate interleukin‐4 induced human immunoglobuline E synthesis in vitro

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