Prooxidant activity of norbixin in model of acute gastric ulcer induced by ethanol in rats

Rovani, BT; Freitas, RB; Augusti, Paula Rossini; Araldi, IC; Somacal, Sabrina; Quatrin, Andréia; Emanuelli, Tatiana; Rocha, MP; Bauermann, Liliane de Freitas

doi:10.1177/0960327115604199

Cited by 5 publications

(2 citation statements)

References 49 publications

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“…Reactive oxygen species (ROS) are responsible for human disorders such as inflammation, neurodegenerative disorders, gastrointestinal inflammation, and ulcers [38]. ROS are generated by the metabolism of arachidonic acid, macrophages, and smooth muscle cells, contributing to gastric mucosal damage.…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of Carotenoid Extract from Orange-Fleshed Sweet Potato on Gastric Ulcer in Mice by Inhibition of NO, IL-6 and PGE2 Production

et al. 2021

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Ipomoea batatas (L.) Lam., Convolvulaceae is widely distributed in Asian areas from tropical to warm-temperature regions. Their tubers are known for their antioxidant, anti-bacterial, anti-diabetic, wound healing, anti-inflammatory, and anti-ulcer activities. The preventive and therapeutic effects of orange-fleshed sweet potato on gastric ulcers have not been investigated. In this study, the carotenoid extract (CE) of orange-fleshed sweet potato was found to protect against gastric ulcers induced by HCl/ethanol in mice. The anti-inflammatory and antioxidant activities of the carotenoid pigment extract were also evaluated as possible evidence of their protective effects. Administration of CE reduced gastric ulcers. Oral administration of CE (100 mg/kg) protected against gastric ulcers by 78.1%, similar to the positive control, sucralfate (77.5%). CE showed potent reducing power and decreased nitric oxide production in a mouse macrophage cell line, RAW 264.7, in a concentration-dependent manner. The production of the inflammatory cytokine interleukin-6 and prostaglandin E2 was also reduced by CE in a dose-dependent manner. The high carotenoid content of orange-fleshed sweet potato could play a role in its protective effect against gastric ulcers. This result suggests the possibility of developing functional products using this nutrient-fortified material.

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Section: Discussionmentioning

confidence: 99%

Protective Effect of Carotenoid Extract from Orange-Fleshed Sweet Potato on Gastric Ulcer in Mice by Inhibition of NO, IL-6 and PGE2 Production

et al. 2021

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“…in the gastric mucosa, which maintains the structural and functional integrity of the mucosa and protects it from invasive factors. 32,33 Free radicals and oxidative stress play a central role in gastric injuries caused by ethanol, 34 where reactive oxygen species play a vital role in destroying the gastric mucosa. Ethanol promotes the overproduction of ROS, which attack the gastric mucosa and reduce antioxidants.…”

Section: Discussionmentioning

confidence: 99%

Effect of white jade snail secretion on antioxidant capacity and intestinal microbial diversity in mouse model of acute gastric ulcer

Cheng,

Wang,

et al. 2023

J Sci Food Agric

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BackgroundIn the present work, acute gastric ulcer models were constructed by administering hydrochloric acid/ethanol. The mice ingested WJSS through gastric infusion. Ulcer areas in gastric tissue were recorded, and malondialdehyde (MDA) and superoxide dismutase (SOD) were also measured. Notably, high‐throughput 16s rDNA analysis of intestinal flora and determination of amino acid composition in feces were performed to understand the effect of WJSS on model mice.ResultsCompared with the control group, the ulcer area in the WJSS low, middle and high‐concentration groups declined by 28.02%, 39.57% and 77.85%. The MDA content decreased by 24.71%, 49.58% and 64.25%, and the SOD relative enzyme activity fell by 28.19%, 43.37% and 9.60%. The amounts of amino acids in the low, middle and high‐concentration groups were slightly lower, and probiotic bacteria such as Bacteroidetes and Lactobacillales increased in different concentration WJSS groups. Adding WJSS contributes to the establishment of beneficial intestinal flora and the absorption of amino acids.ConclusionOur results showed that WJSS has a good effect on inhibiting the hydrochloric acid‐ethanolic gastric ulcer, suggesting that WJSS has excellent potential as a novel anti‐ulcer agent. Combined with ulcer area, MDA content, SOD content, gut probiotics and other indicators, a high concentration of WJSS had the best protective effect on acute gastric.This article is protected by copyright. All rights reserved.

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Protective Effects of Carotenoids in Cardiovascular Disease and Diabetes

Emanuelli

Augusti

Roehrs

2017

Fruit and Vegetable Phytochemicals

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Prooxidant activity of norbixin in model of acute gastric ulcer induced by ethanol in rats

Cited by 5 publications

References 49 publications

Protective Effect of Carotenoid Extract from Orange-Fleshed Sweet Potato on Gastric Ulcer in Mice by Inhibition of NO, IL-6 and PGE2 Production

Protective Effect of Carotenoid Extract from Orange-Fleshed Sweet Potato on Gastric Ulcer in Mice by Inhibition of NO, IL-6 and PGE2 Production

Effect of white jade snail secretion on antioxidant capacity and intestinal microbial diversity in mouse model of acute gastric ulcer

Protective Effects of Carotenoids in Cardiovascular Disease and Diabetes

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