Prooxidant potential of CeO2 nanoparticles towards hydrogen peroxide

Sozarukova, Madina M.; Проскурнина, Е. В.; Иванов, В. К.

doi:10.17586/2220-8054-2021-12-3-283-290

Cited by 16 publications

(4 citation statements)

References 42 publications

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“…Such an ultra-small size makes it possible to ensure high efficiency of endocytosis into various cell types, including hMScs, and can also minimize the risk of an immune response of the body upon their direct injection into the bloodstream. In PBS, the aggregation of the NPs is more pronounced, and is connected to the strong chemisorption of phosphates on the surface of Gd-doped ceria, which affects the bioactivity of NPs [ 41 , 42 ].…”

Section: Resultsmentioning

confidence: 99%

Heavily Gd-Doped Non-Toxic Cerium Oxide Nanoparticles for MRI Labelling of Stem Cells

et al. 2023

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Recently, human mesenchymal stem cells (hMSc) have attracted a great deal of attention as potential therapeutic agents in the treatment of socially significant diseases. Despite substantial advances in stem-cell therapy, the biological mechanisms of hMSc action after transplantation remain unclear. The use of magnetic resonance imaging (MRI) as a non-invasive method for tracking stem cells in the body is very important for analysing their distribution in tissues and organs, as well as for ensuring control of their lifetime after injection. Herein, detailed experimental data are reported on the biocompatibility towards hMSc of heavily gadolinium-doped cerium oxide nanoparticles (Ce0.8Gd0.2O2−х) synthesised using two synthetic protocols. The relaxivity of the nanoparticles was measured in a magnetic field range from 1 mT to 16.4 T. The relaxivity values (r1 = 11 ± 1.2 mM−1 s−1 and r1 = 7 ± 1.2 mM−1 s−1 in magnetic fields typical of 1.5 and 3 T MRI scanners, respectively) are considerably higher than those of the commercial Omniscan MRI contrast agent. The low toxicity of gadolinium-doped ceria nanoparticles to hMSc enables their use as an effective theranostic tool with improved MRI-contrasting properties.

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Section: Resultsmentioning

confidence: 99%

Heavily Gd-Doped Non-Toxic Cerium Oxide Nanoparticles for MRI Labelling of Stem Cells

et al. 2023

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“…The ROS generating system contained hydrogen peroxide and luminol was used as a chemiluminescent probe. The technique of chemiluminescence analysis is described in detail in [28]. The required amounts of luminol (50 µM) and H 2 O 2 (980 µM) were added to cuvettes with phosphate buffer solution (100 mM, pH 7.4), the total volume of the system was 1.000 ml.…”

Section: Characterization Methodsmentioning

confidence: 99%

Photochromic aerogels based on cellulose and chitosan modified with WO3 nanoparticles

Kameneva¹,

Popkov²,

Tronev³

et al. 2022

Nanosystems: Phys. Chem. Math.

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In this work, we report the first synthesis of photochromic aerogels and films based on TEMPOoxidized cellulose and chitosan modified with tungsten trioxide nanoparticles. The blue coloring of aerogels based on WO 3 -modified biopolymers under UV light occurs due to the reduction of W +6 to W +5 . The coloration of films of the same composition occurs due to the reduction of W +6 to W +5 and W +4 . The photochromic properties of aerogels and films are reversible; oxidation by atmospheric oxygen leads to bleaching of materials. At that, films become colorless within a few days while aerogels with a high specific surface area (200 m 2 /g) become colorless within several minutes. The antioxidant properties of the WO 3 sol and the WO 3 /TEMPOoxidized cellulose/chitosan composite were studied by luminol-activated chemiluminescence method. The antioxidant capacity of WO 3 /TEMPO-oxidized cellulose/chitosan gel is 1.5 times higher than that of the commercially available antioxidant mexidol. KEYWORDS Aerogel, hybrid materials, nanocomposite, biopolymers, cellulose, chitosan, tungsten oxide, photochromic material, antioxidant. ACKNOWLEDGEMENTS S. V. Kameneva thanks the Council for Grants of the President of the Russian Federation for supporting the study (SP-4398.2021.4).

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“…The kinetic parameters of the luminol oxidation reactions with hydrogen peroxide in the presence of CeO 2 were mathematically modelled (Figure 7b). At the first stage, the interaction of cerium dioxide with H 2 O 2 with the formation of hydroxyl radicals was considered [67]. The chosen kinetic model of H 2 O 2 -induced luminol oxidation includes the decomposition of hydrogen peroxide (2), the interaction of luminol with hydroxyl radicals (3), and the final stage of chemiluminescence (4), where P is the reaction product:…”

Section: Enzyme-like Activity Of Ceo 2 Sols Towards H 2 O 2 Decomposi...mentioning

confidence: 99%

Peroxidase-like Activity of CeO2 Nanozymes: Particle Size and Chemical Environment Matter

et al. 2023

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The enzyme-like activity of metal oxide nanoparticles is governed by a number of factors, including their size, shape, surface chemistry and substrate affinity. For CeO2 nanoparticles, one of the most prominent inorganic nanozymes that have diverse enzymatic activities, the size effect remains poorly understood. The low-temperature hydrothermal treatment of ceric ammonium nitrate aqueous solutions made it possible to obtain CeO2 aqueous sols with different particle sizes (2.5, 2.8, 3.9 and 5.1 nm). The peroxidase-like activity of ceria nanoparticles was assessed using the chemiluminescent method in different biologically relevant buffer solutions with an identical pH value (phosphate buffer and Tris-HCl buffer, pH of 7.4). In the phosphate buffer, doubling CeO2 nanoparticles’ size resulted in a two-fold increase in their peroxidase-like activity. The opposite effect was observed for the enzymatic activity of CeO2 nanoparticles in the phosphate-free Tris-HCl buffer. The possible reasons for the differences in CeO2 enzyme-like activity are discussed.

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Prooxidant potential of CeO2 nanoparticles towards hydrogen peroxide

Cited by 16 publications

References 42 publications

Heavily Gd-Doped Non-Toxic Cerium Oxide Nanoparticles for MRI Labelling of Stem Cells

Heavily Gd-Doped Non-Toxic Cerium Oxide Nanoparticles for MRI Labelling of Stem Cells

Photochromic aerogels based on cellulose and chitosan modified with WO3 nanoparticles

Peroxidase-like Activity of CeO2 Nanozymes: Particle Size and Chemical Environment Matter

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