Propafenone for supraventricular arrhythmias in septic shock—Comparison to amiodarone and metoprolol

Management of arrhythmia in sepsis and septic shock

“…These were not significantly different to chronic AF patients with an ICU mortality of 38.2% and a 28-day mortality of 41.1% [18]. Despite treatment, according to available data, some 30-35% of patients [5,14,18,19] remain in NOAF.…”

“…The most common arrhythmia is a new-onset atrial fibrillation (NOAF) [17], which represents up to 70% of all SV arrhythmias in septic shock [18]. Besides NOAF, 14.5% of patients present with chronic AF [18].…”

“…Besides NOAF, 14.5% of patients present with chronic AF [18]. NOAF is associated with a prolonged ICU length of stay and a higher SOFA score, while failure to restore a sinus rhythm is associated with increased mortality [18][19][20]. A typical time to arrhythmia onset is within the first 72h from the onset of septic shock [5,18,19,21].…”

“…NOAF is associated with a prolonged ICU length of stay and a higher SOFA score, while failure to restore a sinus rhythm is associated with increased mortality [18][19][20]. A typical time to arrhythmia onset is within the first 72h from the onset of septic shock [5,18,19,21]. The overall cardioversion rate has been reported as between 70% and 87%, including all those with additional electric cardioversion [18,19,21].…”

“…A typical time to arrhythmia onset is within the first 72h from the onset of septic shock [5,18,19,21]. The overall cardioversion rate has been reported as between 70% and 87%, including all those with additional electric cardioversion [18,19,21].…”