Propagation of acid proximally in the esophagus is associated with reflux perception in non erosive and in erosive gastro-esophageal reflux disease

Emerenziani, Sara; Caviglia, Renato; Guarino, Michele Pier Luca; Vavassori, Piero; Petitti, Tommasangelo; Ribolsi, Mentore; Mangiavillano, Benedetto; Cicala, Michele

doi:10.1016/s0016-5085(03)82064-4

Cited by 1 publication

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“…While the threshold for defining an acid reflux event has been set at an arbitrary pH of 4 or less, there is some data to suggest that pH changes higher than pH of 4 are sufficient to produce heartburn symptoms that may be incapacitating in some patients 12 ,. 24 Recently, researchers from Italy 25 proposed that assessment of acid distribution in the oesophageal body could further our understanding of symptom generation in ENRD patients, although it remains unclear as to why those with ENRD would be more prone to develop symptoms as a result of proximal acid exposure.…”

Section: The Aetiology Of Heartburnmentioning

confidence: 99%

Approaches to endoscopic‐negative reflux disease: part of the GERD spectrum or a unique acid‐related disorder?

Tack

Fass

2004

Aliment Pharmacol Ther

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SUMMARYEndoscopic-negative reflux disease (ENRD) is the most common presentation of gastro-oesophageal reflux disease (GERD)-affecting up to 70% of these individuals. In the last three decades therapeutic studies have focused solely on the treatment of patients with erosive oesophagitis. However, more recent studies have shifted our attention to defining, understanding and treating those with ENRD. GERD has traditionally been approached as a spectrum with ENRD at the mild end and complicated GERD (i.e. patients with erosive oesophagitis, stricture and Barrett's oesophagus) being at the other end, suggesting that patients' disease may progress over time along the spectrum. Current data indicate that ENRD should be approached as a unique entity rather than a part of the GERD spectrum and that over time only a few patients with ENRD will develop GERD-related complications.

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Section: The Aetiology Of Heartburnmentioning

confidence: 99%