Propagation of Epileptic Discharge from Chronic Neocortical Foci in Monkey

Abruptly Attenuated Terminal Ictal Pattern in Pediatrics

“…The anterior thalamus (Hodaie et al, 2002), centromedian thalamus (Fisher et al, 1992), substantia nigra pars reticulata (Moshe 1997), and dorsal midbrain anticonvulsant zone (Shehab et al, 1995) have all been proposed as key nodes in the endogenous anticonvulsant circuitry, where an external stimulus can be applied to activate this circuit and suppress seizures. Wilder and Schmidt (1965) observed a strikingly similar pattern with subdural and depth electrode studies in epileptic monkeys. They observed that there was ".…”

Anticonvulsant Drugs1 I

“…This is startling when the clinical expression of a motor seizure is abolished with phenytoin or other drugs, without abolishing the cortical focal discharge ( Louis et al, 1968;. It is also compatible with the findings of Wilder and Schmidt (1965) that for the clinical expression of a seizure, deep grey matter requires to be involved. This phenomenon is in line with previous work demonstrating pyramidal and non-pyramidal pathways for spinal propagation of seizure discharge (Mettler and Mettler, 1940;Halliday, 1967), both pathways being required to converge on anterior horn cells to provoke their participation and consequent clinical expression.…”

“…Alumina cream produces an epileptic preparation most closely resembling human focal epilepsy. Wilder and Schmidt (1965) have shown that spread must involve the deep grey nuclei whenever clinically manifest seizures occur. Each of these produces spike activity in the focus, with at times after-discharges, followed in some preparations by spread of epileptic discharge in the cortical surround and to the contralateral cortex.…”

A Study of Pulvinar‐cortical Interaction in Acute Tungstic Acid‐induced Epilepsy in the Cat

“…After extensive experiments in the monkey, Walker and Udvarhelyi (1965), studying the propagation of seizure activity from subcortical nuclear masses, concluded that the thalamus is unlikely to originate or augment an epileptic cortical discharge. Wilder and Schmidt (1965) also concluded that the thalamus is not involved in the generation of cortical seizures but they suggest the thalamus may influence seizure activity by means of an active inhibitory process. However, Aquino-Cias and BureS (1967) found that seizure incidence was reduced by functional elimination of the thalamus and suggest that the thalamus may play a role in the actual generation of seizure activity.…”