Propagation of New Delhi Metallo-β-lactamase Genes (<i>bla</i><sub>NDM-1</sub>) from a Wastewater Treatment Plant to Its Receiving River

Yang, Fengxia; Mao, Daqing; Zhou, Hao; Wang, Xiaolong; Luo, Yi

doi:10.1021/acs.estlett.6b00036

Cited by 37 publications

(21 citation statements)

References 51 publications

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“…In this case, upstream biofilm samples yielded negative results for the bla NDM gene, thus suggesting that the treated effluent is likely to be responsible for the presence of this gene at downstream locations. This is consistent with findings by Yang and coworkers, who found that the prevalence of bla NDM‐1 in river water is directly linked to WWTP effluent discharges (Yang, Mao, Zhou, Wang, & Luo, ).…”

Section: Discussionsupporting

confidence: 92%

Wastewater pollution differently affects the antibiotic resistance gene pool and biofilm bacterial communities across streambed compartments

et al. 2017

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Wastewater discharges introduce antibiotic residues and antibiotic-resistant bacteria (ARB) into surface waters. Both inputs directly affect the streambed resistome, either by exerting a selective pressure that favour the proliferation of resistant phenotypes or by enriching the resident communities with wastewater-associated ARB. Here, we investigated the impact of raw and treated urban wastewater discharges on epilithic (growing on rocks) and epipsammic (growing on sandy substrata) streambed biofilms. The effects were assessed by comparing control and impact sites (i) on the composition of bacterial communities; (ii) on the abundance of twelve antibiotic resistance genes (ARGs) encoding resistance to β-lactams, fluoroquinolones, sulphonamides, tetracyclines, macrolides and vancomycin, as well as the class 1 integron-integrase gene (intI1); (iii) on the occurrence of wastewater-associated bacteria, including putative pathogens, and their potential linkage to target ARGs. We measured more pronounced effects of raw sewage than treated wastewater at the three studied levels. This effect was especially noticeable in epilithic biofilms, which showed a higher contribution of wastewater-associated bacteria and ARB than in epipsammic biofilms. Comparison of correlation coefficients obtained between the relative abundance of both target ARGs and operational taxonomic units classified as either potential pathogens or nonpathogens yielded significant higher correlations between the former category and genes intI1, sul1, sul2 and ermB. Altogether, these results indicate that wastewater-associated micro-organisms, including potential pathogens, contribute to maintain the streambed resistome and that epilithic biofilms appear as sensitive biosensors of the effect of wastewater pollution in surface waters.

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Section: Discussionsupporting

confidence: 92%

Wastewater pollution differently affects the antibiotic resistance gene pool and biofilm bacterial communities across streambed compartments

et al. 2017

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“…Multiple variants of bla NDM have been identified in clinical and environmental samples [33]. Our results further supplement previous studies that show NDM-1 to be widely distributed in wastewater in China [20,34,35]. We also found that NDM-5, which exhibits increased resistance to carbapenems and broad-spectrum cephalosporins [33], was also highly prevalent in the collected samples.…”

Section: Discussionsupporting

confidence: 88%

The Prevalence and Characterization of Extended-Spectrum β-Lactamase- and Carbapenemase-Producing Bacteria from Hospital Sewage, Treated Effluents and Receiving Rivers

Zhang

Luo

et al. 2020

IJERPH

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Hospital sewage plays a key role in the dissemination of antibiotic-resistant genes (ARGs) by serving as an environmental antimicrobial resistance reservoir. In this study, we aimed to characterize the cephalosporin- and carbapenem-resistant isolates from hospital sewage and receiving rivers. The results showed that ESBL (blaCTX-M) and carbapenemase genes (blaNDM and blaKPC) were widely detected in a number of different bacterial species. These resistance genes were mainly harbored in Enterobacteriaceae, followed by Acinetobacter and Aeromonas isolates. More attention should be given to these bacteria as important vectors of ARGs in the environment. Furthermore, we showed that the multidrug resistance phenotype was highly prevalent, which was found in 85.5% Enterobacteriaceae and 75% Acinetobacter strains. Notably, the presence of carbapenemase genes in isolates from treated effluents and receiving rivers indicates that the discharges of wastewater treatment plants could be an important source for high-risk resistance genes propagation to the environment. In conclusion, this study shows a high prevalence of ESBL- and carbapenemase-producing bacteria in hospital sewage and receiving rivers in China. These findings have serious implications for human health, and also suggest the need for more efforts to control the dissemination of resistant bacteria from hospital sewage into the environment.

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“…Aside from human-populated environments, CR can also spread into the natural milieu, including aquatic environments [42,[56][57][58]. CRGs, such as bla NDM-1 , bla KPC-2 , and bla OXA-58 , have also been reported in known environmental bacteria, such as Acinetobacter johnsonii [59] and Acinetobacter towneri [60].…”

Section: Epidemiology and Distribution Of Carbapenem Resistancementioning

confidence: 99%

Carbapenem Resistance among Marine Bacteria—An Emerging Threat to the Global Health Sector

et al. 2021

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The emergence of antibiotic resistance among pathogenic microorganisms is a major issue for global public health, as it results in acute or chronic infections, debilitating diseases, and mortality. Of particular concern is the rapid and common spread of carbapenem resistance in healthcare settings. Carbapenems are a class of critical antibiotics reserved for treatment against multidrug-resistant microorganisms, and resistance to this antibiotic may result in limited treatment against infections. In addition to in clinical facilities, carbapenem resistance has also been identified in aquatic niches, including marine environments. Various carbapenem-resistant genes (CRGs) have been detected in different marine settings, with the majority of the genes incorporated in mobile genetic elements, i.e., transposons or plasmids, which may contribute to efficient genetic transfer. This review highlights the potential of the marine environment as a reservoir for carbapenem resistance and provides a general overview of CRG transmission among marine microbes.

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Propagation of New Delhi Metallo-β-lactamase Genes (bla_NDM-1) from a Wastewater Treatment Plant to Its Receiving River

Cited by 37 publications

References 51 publications

Wastewater pollution differently affects the antibiotic resistance gene pool and biofilm bacterial communities across streambed compartments

Wastewater pollution differently affects the antibiotic resistance gene pool and biofilm bacterial communities across streambed compartments

The Prevalence and Characterization of Extended-Spectrum β-Lactamase- and Carbapenemase-Producing Bacteria from Hospital Sewage, Treated Effluents and Receiving Rivers

Carbapenem Resistance among Marine Bacteria—An Emerging Threat to the Global Health Sector

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Propagation of New Delhi Metallo-β-lactamase Genes (blaNDM-1) from a Wastewater Treatment Plant to Its Receiving River

Cited by 37 publications

References 51 publications

Wastewater pollution differently affects the antibiotic resistance gene pool and biofilm bacterial communities across streambed compartments

Wastewater pollution differently affects the antibiotic resistance gene pool and biofilm bacterial communities across streambed compartments

The Prevalence and Characterization of Extended-Spectrum β-Lactamase- and Carbapenemase-Producing Bacteria from Hospital Sewage, Treated Effluents and Receiving Rivers

Carbapenem Resistance among Marine Bacteria—An Emerging Threat to the Global Health Sector

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Propagation of New Delhi Metallo-β-lactamase Genes (bla_NDM-1) from a Wastewater Treatment Plant to Its Receiving River