Propagation patterns of jejunal motor activity measured by high‐resolution water‐perfused manometry

Abstract

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Effect of colonic distension on small bowel motility measured by jejunal high‐resolution manometry

“…Jejunal motility was measured by high‐resolution manometry, using a technique that has been described before in detail 6 . In brief, a customized 35‐channel perfusion catheter (Mui Scientific) made of silicone (external diameter of 4.7 mm) was used.…”

“…Manometric recordings were analyzed (by CM and LA) both visually and using the MMS Database Software v9.5h (MMS‐Laborie), as previously described 6 …”

“…Jejunal motility was measured by high-resolution manometry, using a technique that has been described before in detail. 6 In brief, a customized 35-channel perfusion catheter (Mui Scientific) made of silicone (external diameter of 4.7 mm) was used. Perfusion side-holes (recording sites) were located 58 and 48 cm from the tip of the catheter, to register antral and duodenal contractions, respectively; the following 33 sideholes were spanned at 1-cm intervals from 37 to 5 cm from the tip, to measure jejunal contractile activity.…”

“…[3][4][5] The jejunal response to colonic distension was evaluated by means of high-resolution manometry (HRM) with multiple, closely spaced recording sites, because recent studies showed that HRM identifies motor features undetectable by conventional manometry. 6…”

Interstitial cells of Cajal and human colon motility in health and disease

“…This wave of neural activity excites the ICC-MP network and the smooth musculature, generating anally propagating, propulsive, lumen-occluding pressure waves at the frequency and propagation velocity determined by the ICC-MP network. This activity is illustrated effectively using high-resolution manometry by Conklin et al (61) and Alcala-Gonzalez et al (62). The neural wave of excitation evokes 3 cycles/min propulsive contractions in the stomach, followed by 12-cycles/min propulsive contractions in the proximal small intestine.…”