Propamocarb exposure decreases the secretion of neurotransmitters and causes behavioral impairments in mice

Abstract

Propamocarb (PM) is a type of fungicide, which is widely used in the greenhouse-based production of vegetables and fruits globally. It has been considered to have generally low toxicity. However, the teratogenicity or neurotoxicity for mammals remains unclear. In this study, we aimed to explore its effect on the secretion of neurotransmitters and behavioral impairments.Male adult mice were exposed to 10 and 40 mg/L PM for 2 weeks (acute exposure) or 3 and 10 mg/L PM for 10 weeks (chronic exposure). It was observed that acute or chronic exposure to PM changed the levels of serotonin (5-HT) and dopamine in the serum and colon and the transcription of TPH2 and DRD2 in the colons of mice. In addition, the locomotor test, the open field test, and the Morris water maze analysis also showed that acute exposure to PM caused behavioral impairments to some extent. The results obtained in the present study indicated that PM has the potential to induce neurotoxicity in animals. K E Y W O R D Sbehavioral impairments, mice, neurotoxicity, neurotransmitters, propamocarb

Appraisal for Edible Use of Vegetable Crops Cultivated in Egypt after Treatment with Selected Insecticides and Fungicides: Insights of Dissipation Rates and Pre-harvest Intervals

“…Literature revealed several chromatographic methods reported for the analysis of propamocarb residues alone or in combintions with other carbamates such as LC-MS [29][30][31][32] , HPLC -DAD 33 and GC-MS 34 . Acute and chronic exposure to propamocarb showed alterations in locomotor activity and behavioral impairments in mice 35 . In addition, propamocarb was identified as an estrogenic compound which affects α and β estrogen receptors 36 .…”

Pesticides and the Microbiome-Gut-Brain Axis: Convergent Pathways in the Pathogenesis of Parkinson’s Disease

“…There is sufficient evidence that pesticides can impair gut barrier function by destroying intestinal mucosa and affecting the crosstalk between mucus and gut bacteria [166,167]. They alter the overall composition of gut microbiota and affect their metabolites, leading to pathological changes by acting on receptor sites of different tissues and organs [168]. It is time to seriously consider the gut microbiota as an unintended recipient of pesticidal pollution and to focus on the long-term effects of chronic exposure on microbial diversity and subsequent influence on the host [29].…”

Bazı Fungusitlerin Genotoksik Potansiyellerinin Drosophila SMART ve KOMET Yöntemleri ile Araştırılması

“…dahil olmak üzere çeşitli oomycetes mantarlarının gelişimindeki tüm aktif büyüme aşamalarını inhibe ederek etkilerini gösterdikleri bilinmektedir [49]. Propamocarbın erkek yetişkin farelerdeki nörotransmitter salgısı ve davranış üzerine gerçekleştirilen bir çalışmada propamocarb maruziyetinin lokomotor aktivite üzerinde bozukluğa ve nörotoksisiteyi indükleme potansiyeline sahip olduğu tespit edilmiştir [50]. Zebra balıkları üzerinde propamocarb maruziyetinin araştırıldığı bir başka çalışmada da benzer şekilde propamocarb maruziyetinin gelişim, lokomotor aktivite ve oksidatif stres üzerinde negatif etkiye sahip olabileceği gösterilmiştir [4].…”