Propensity-Matched Outcomes of Transcarotid Artery Revascularization Versus Carotid Endarterectomy

Perioperative outcomes of carotid endarterectomy and transfemoral and transcervical carotid artery stenting in radiation-induced carotid lesions

“…10 Embolic protection is provided by flow reversal, resulting in outcomes similar to those achieved with CEA. 10,11 However, studies have shown that the lesions in patients with RICS differ from the typical atherosclerotic plaques seen in nonradiated patients. Specifically, carotid lesions in patients with previous cervical radiation are more fibrotic and less inflammatory than atherosclerotic lesions in nonradiated patients.…”

The Efficacy of Transcarotid Artery Revascularization With Flow Reversal System Compared to Carotid Endarterectomy: A Systematic Review and Meta-Analysis

“…The research of Plessers et al was supported by scientific funding from Belgium (33). Although these three studies have reported no funding obtained (34)(35)(36), at least one author in each article has ever received sponsorship or served as a consultant in the Silk Road Medical, which is an institution responsible for researching and developing TCAR with flow reversal system. The residual two literature have none of the above situations (32,37).…”

“…A total of 174 articles were obtained through the retrieval flow, thereafter removing duplicates and screening abstracts or full texts, the remaining six comparative cohort research studies were finally selected in this meta-analysis (32)(33)(34)(35)(36)(37). Among all excluded studies, an overlapping investigation might occur in eight trials.…”

“…According to our independent adjudication, four of six works of literature were moderate quality and the other two were high quality by the NOS scale (Table 3). In terms of comparability of cohorts, Kashyap et al (34), Malas et al (35), and Yee et al (36) have adjusted critical confounders containing age, gender, symptom status, hyperlipidemia, diabetes, and hypertension. Either age and gender or common comorbidities were balanced against between two arms in the remaining articles (32,33,37).…”

“…Firstly, no randomized controlled trial could be obtained during searching databases, only several cohort studies met pre-specified inclusion criteria, which have increased the risk of bias and weakened evidence. Besides, the definition of stroke in the research of Yee et al (36) includes transient ischemic attack, hence, after eliminating it, the decline of sample size would affect OR. No economic data were available so that could not be analyzed in this study to guide clinical choice.…”