Properative psychological variables predict immunological status in patients with operable breast cancer

Tjemsland, Lars; Søreide, Jon Arne; Matre, R.; Malt, Ulrik Fredrik

doi:10.1002/(sici)1099-1611(199712)6:4<311::aid-pon285>3.0.co;2-c

Cited by 50 publications

(25 citation statements)

References 38 publications

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“…As previously reported (Tjemsland, Soreide, Matre, & Malt, 1997), depressive symptoms were elevated in women in treatment for breast cancer relative to that evident among individuals posttreatment and those in the control group. It is, of course, understandable that depressive symptoms would be elevated among women battling a potentially terminal illness, and indeed 25% of women in the current study reported Beck depression scores within the range of moderate depressive illness (> 18) (Beck & Steer, 1987).…”

Section: Discussionsupporting

confidence: 72%

Trust in Physician in Relation to Blame, Regret, and Depressive Symptoms Among Women with a Breast Cancer Experience

Taha

Matheson

Paquet

et al. 2011

Journal of Psychosocial Oncology

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Following a diagnosis of breast cancer women experience considerable distress and often present with elevated symptoms of depression. A woman's relationship with her oncologist, and particularly trust in the physician, might influence depressive symptoms, as well as emotional and cognitive reactions to medical decisions made concerning treatment. To assess these relationships, women currently undergoing treatment for breast cancer (n = 40) and women who had previously been treated for breast cancer (n = 74) were asked about (1) trust in their physician, (2) who they blamed for negative events during treatment, (3) who made the treatment decisions, (4) regret, and (5) depressive symptoms. As well, community participants (n = 146) without breast cancer were asked about trust in their physician, levels of depression, and questions regarding blame if they hypothetically had breast cancer. Depression was greatest among women in treatment, and trust in physician was greatest among women posttreatment. However, trust in physician was neither related to depressive symptoms, decision making, nor responsibility for presence of metastases/relapse. Paradoxically, greater trust in physician was related to increased blame of the doctor for other negative events that had occurred. Furthermore, depressive scores were higher among women who blamed their doctor for negative events in comparison to women who ascribed blame to no one. As well, individuals who blamed themselves for negative events reported greater regret than individuals who blamed no one. Thus, though a woman may not hold her physician directly responsible for health outcomes, this relationship may be important to consider in other aspects of her psychological well-being.

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Section: Discussionsupporting

confidence: 72%

Trust in Physician in Relation to Blame, Regret, and Depressive Symptoms Among Women with a Breast Cancer Experience

Taha

Matheson

Paquet

et al. 2011

Journal of Psychosocial Oncology

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“…Various possible mechanisms have been suggested; impact on immune status [7], effect on stress hormones [8], or behavioural changes associated with psychological response [9] that may impede effective treatment (e.g., treatment stopped or delayed due to patientsÕ inability to cope). Evidence from general psychiatry may yield some clues concerning the latter mechanism.…”

Section: Discussionmentioning

confidence: 99%

Influence of psychological response on breast cancer survival: 10-year follow-up of a population-based cohort

Watson

Homewood

Haviland

et al. 2005

European Journal of Cancer

191

120

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The possibility that psychological response within a few weeks of a breast cancer diagnosis can influence the outcome of the disease is a contentious issue. Psychological response, including helplessness/hopelessness, fighting spirit and depression was assessed in early-stage breast cancer patients between 1 and 3 months post-diagnosis, in order to ascertain effect on cancer prognosis. Patients were followed up for a period of 10 years in order to clarify the effect of psychological response on disease outcome. After 10 years, there is a continuing effect of helplessness/hopelessness on disease-free survival (adjusted hazard ratio (HR) 1.53, 95% confidence interval (CI) 1.11-2.11) but not of depression (adjusted HR for overall survival for ÔcasesÕ 2.43, 95% CI 0.97-6.10). Longer follow-up also indicates that a high fighting spirit confers no survival advantage. The results showed that, in patients who were disease-free at 5 years, their baseline helpless/hopeless response still exerted a significant effect on disease-free survival beyond 5 (and up to 10) years. The effect is therefore maintained for up to 10 years of follow-up. Clinicians may wish to screen for helplessness around the time of diagnosis in order to target psychological care resources. Further large studies, with similarly prolonged follow-up, are needed to replicate this effect and clarify its mechanism of action.

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“…However, the greatest decreases in our sample occurred on the more cognitive subscales of depression and irritability/anger. The literature detailing the psychological rather than physiological benefits of meditation contains reports of decreases in depression symptoms and enhanced psychological well-being in cancer patients [61], in patients with anxiety disorders [33] and in healthy populations [2,24,26]. It is of interest to note that several groups have begun investigating meditation as an adjunctive component of more cognitive-behaviorally based programs designed to treat major depressive disorder [59] and alcohol abuse [46].…”

Section: Discussionmentioning

confidence: 99%

The effects of a mindfulness meditation-based stress reduction program on mood and symptoms of stress in cancer outpatients: 6-month follow-up

Carlson

Ursuliak

Goodey

et al. 2001

Support Care Cancer

306

172

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Properative psychological variables predict immunological status in patients with operable breast cancer

Cited by 50 publications

References 38 publications

Trust in Physician in Relation to Blame, Regret, and Depressive Symptoms Among Women with a Breast Cancer Experience

Trust in Physician in Relation to Blame, Regret, and Depressive Symptoms Among Women with a Breast Cancer Experience

Influence of psychological response on breast cancer survival: 10-year follow-up of a population-based cohort

The effects of a mindfulness meditation-based stress reduction program on mood and symptoms of stress in cancer outpatients: 6-month follow-up

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