Properdin factor B and complement factor C4 allotypes in rheumatoid arthritis: Results of a follow-up study

Zeben, Derkjen van; Giphart, Marius J.; Christiansen, F.; Hoetjer, M.; Meyer, Ellen; Breedveld, F. C.

doi:10.1016/0198-8859(92)90066-v

Cited by 8 publications

(5 citation statements)

References 15 publications

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“…6 The inflammation markers, or C-reactive protein and erythrocyte sedimentation rates, are also used to monitor the disease state of RA. 7 However, the false positive rate is relatively high with these measurements. In this sense, early diagnosis of RA still remains a challenge in the clinical setting.…”

Section: Introductionmentioning

confidence: 90%

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Application of a Novel Protein Biochip Technology for Detection and Identification of Rheumatoid Arthritis Biomarkers in Synovial Fluid

et al. 2002

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We compared protein profiles of the synovial fluid of patients with rheumatoid arthritis and osteoarthritis by using surface-enhanced laser desorption/ionization mass spectrometry technology. With this approach, we identified a protein expressed specifically in the synovial fluid of the patients with rheumatoid arthritis. During the investigation, we found several reproducible and discriminatory biomarker candidates for distinction between rheumatoid arthritis and osteoarthritis. Among these candidates, a 10 850 Da protein peak was the clearest example of a single signal found specifically in the rheumatoid arthritis samples. This candidate was purified using a size-exclusion spin column followed by gel electrophoresis and subsequently identified by peptide mapping and post-source decay (PSD) analysis. The results clearly indicate that the protein is myeloid-related protein 8, which was verified by the enzyme immunoassay. It is known that the myeloid-related protein 8 level in serum and synovial fluid is related to disease activity in juvenile rheumatoid arthritis. The results suggest that the ProteinChip platform is useful to detect and identify protein biomarkers expressed specifically in diseases or in some stage of diseases.

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Section: Introductionmentioning

confidence: 90%

“…So far, the most popular diagnosis of RA is the measurement of RA factor, or the antibody against the Fc region of IgG . The inflammation markers, or C-reactive protein and erythrocyte sedimentation rates, are also used to monitor the disease state of RA . However, the false positive rate is relatively high with these measurements.…”

Section: Introductionmentioning

confidence: 99%

Application of a Novel Protein Biochip Technology for Detection and Identification of Rheumatoid Arthritis Biomarkers in Synovial Fluid

et al. 2002

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“…A positive correlation between gene copy number variations of C4 and the quantity of C4 protein has been demonstrated (). Additionally, specific C4 deficiency has been associated with multiple autoimmune disorders, including SLE (), RA (), and juvenile idiopathic arthritis ().…”

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confidence: 99%

Copy Number Variations of Complement Component C4 Are Associated With Behçet's Disease but Not With Ankylosing Spondylitis Associated With Acute Anterior Uveitis

Hou

Liao

et al. 2013

Arthritis & Rheumatism

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Objective. Complement component C4 copy number variations are associated with various inflammatory diseases. This study was undertaken to investigate whether copy number variations of C4 are also involved in the pathogenesis of Behçet's disease (BD).Methods. Gene expression was examined by enzyme-linked immunosorbent assay (ELISA) or realtime polymerase chain reaction (PCR). Copy number variations of C4 isotypes (C4A and C4B) were detected by real-time PCR in 905 patients with BD, 205 patients with ankylosing spondylitis (AS) and acute anterior uveitis, and 1,238 controls. The activation of CD4؉ T cells was analyzed by flow cytometry, and cytokine production was detected by ELISA.Results. Protein expression of total C4 in serum was significantly increased in patients with active BD compared with those with inactive BD or controls (Bonferroni corrected P [P corr ] ‫؍‬ 1.64 ؋ 10 ؊4 and P corr ‫؍‬ 0.037, respectively), but not in patients with AS and acute anterior uveitis. Copy number variation analysis identified a significantly increased frequency of more than 2 copies of C4A in BD patients (P ‫؍‬ 1.65 ؋ 10 ؊7 , odds ratio [OR] 2.84). HLA-B51, which is located on the same chromosome as C4, showed a strong association with BD in the Han Chinese population (P ‫؍‬ 8.90 ؋ 10 ؊65 , OR 5.05), but logistic regression showed that C4A copy number variation was an independent risk factor for BD. A significantly increased expression of C4A was observed in the high copy number groups (>2 copies or 2 copies) versus the low copy number group (P corr ‫؍‬ 0.019 and P corr ‫؍‬ 0.044, respectively). Increased production of interleukin-6 (IL-6) was also observed in the high C4A copy number group (P corr ‫؍‬ 0.037). No effect of C4 copy number variation on the expression of T cell activation markers was detected.Conclusion. Our findings indicate that a high copy number of C4A confers risk for BD by modulating the expression of C4A and enhancing IL-6 production.

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“…Neither the C3 nor the BF phenotype frequencies differ significantly between the two patient groups nor between those and healthy children (Table 7). Numerous studies have shown the association between C3 andlor BF phenotypes and diseases such as rheumatoid arthritis (Farhud et al, 1972;Bronnestam, 1973;Harada et al, 1976;Ansel & Albert, 1984;Dahlqvist et al, 1985;Lanchbury et al 1987;Fielder et al, 1989;Van Zeben et al, 1992), renal diseases (Dyer et al, 1980;Papiha etal., 1982;Rogueiro & Arnaiz-Villena, 1984;Papiha & Rodger, 1986;Nishimukai et al, 1988), insulin-dependent diabetes mellitus (Bertrams & Baur, 1984;Hagglof et al, 1986), bronchial asthma (Srivastava et al, 1985), peptic ulcer (Archimandritis et al, 1992), schizophrenia (Rudduck et al, 1985;Fananas el al., 1992) and thyroid cancer (Bernal et al, 1986). Although mumps meningitis has been shown to be associated with HLA class I and class I1 alleles (Matej et al, 1992), we could not find any correlation of BF (encoded in HLA class 111 region and strongly linked to class I and 11) alleles with this disease.…”

Section: R E S U L T Smentioning

confidence: 99%

Phenotype Distribution of the Third Component of Complement (C3) and of the Properdin B Factor (Bf) in Children With Mumps Meningitis

Hałasa

Kacprzak-Bergman

Mańczak

et al. 1993

Int J Immunogenetics

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Properdin factor B and complement factor C4 allotypes in rheumatoid arthritis: Results of a follow-up study

Cited by 8 publications

References 15 publications

Application of a Novel Protein Biochip Technology for Detection and Identification of Rheumatoid Arthritis Biomarkers in Synovial Fluid

Application of a Novel Protein Biochip Technology for Detection and Identification of Rheumatoid Arthritis Biomarkers in Synovial Fluid

Copy Number Variations of Complement Component C4 Are Associated With Behçet's Disease but Not With Ankylosing Spondylitis Associated With Acute Anterior Uveitis

Phenotype Distribution of the Third Component of Complement (C3) and of the Properdin B Factor (Bf) in Children With Mumps Meningitis

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