Properties and Applications of Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) Biocomposites

Ibrahim, Mohammad I.; Alsafadi, Diya; Alamry, Khalid A.; Hussein, Mahmoud A.

doi:10.1007/s10924-020-01946-x

Cited by 47 publications

(21 citation statements)

References 188 publications

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“…PHA applications and their biocomposites were focused in bone scaffolds and tissue engineering 14 , 15 , therapeutics field 16 , 17 , their copolymers 18 and many others 1 , 19 , 20 . PHBV biocomposites and their applications were reviewed in literature 13 , 21 , 22 . PHBV was very much investigated for packaging applications as well 23 – 25 .…”

Section: Introductionmentioning

confidence: 99%

A promising antimicrobial bionanocomposite based poly(3-hydroxybutyrate-co-3-hydroxyvalerate) reinforced silver doped zinc oxide nanoparticles

Ibrahim

Alsafadi

Alamry

et al. 2022

Sci Rep

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A bionanocomposite based on biosynthesized poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) and reinforced with silver@zinc oxide (Ag–ZnO) was synthesized in variable loadings of Ag–ZnO using the in-situ casting dissolution technique. The degradable biopolymer PHBV had been biosynthesized from date waste as a renewable carbon source. The fabricated products were investigated as promising antibacterial materials. The Ag–ZnO nanoparticles were also synthesized using the green method in the presence of Gum Arabic. The Ag–ZnO nanoparticles were loaded within the PHBV biopolymer backbone at concentration of 1%, 3%, 5% and 10%, PHBV/Ag–ZnO(1,3,5,10%). The chemical structure, morphology, physical and thermal properties of the PHBV/Ag–ZnO bionanocomposites were assessed via common characterization tools of FTIR, TGA, XRD, SEM and EDX. One step of the degradation process was observed in the range of 200–220 °C for all the obtained materials. The onset degradation temperature of the bionanocomposites have been noticeably increased with increasing the nanofiller loading percentage. In addition, fabricated products were investigated for their interesting antibacterial performance. A detailed biological screening for the obtained products was confirmed against some selected Gram-positive and Gram-negative strains S. aureus and E. coli, respectively. Overall, the bionanocomposite PHBV/Ag–ZnO(10%) was the most potent against both types of the selected bacteria. The order of bacterial growth inhibition on the surface of the fabricated bionanocomposites was detected as follows: PHBV/Ag–ZnO(10%) > PHBV/Ag–ZnO(5%) > PHBV/Ag–ZnO(3%) > PHBV/Ag–ZnO(1%).

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Section: Introductionmentioning

confidence: 99%

A promising antimicrobial bionanocomposite based poly(3-hydroxybutyrate-co-3-hydroxyvalerate) reinforced silver doped zinc oxide nanoparticles

Ibrahim

Alsafadi

Alamry

et al. 2022

Sci Rep

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“…One method consists in the incorporation of secondary flexible monomers such as 3-hydroxyvalerate, 4-hydroxybutyrate, or 3-hydroxyhexanoate [ 43 ] in the main chain of PHB that led to the formation of PHBV [ 44 ], poly (3-hydroxybutyrate-co-4-hydroxybutyrate) (P4HB) [ 45 ], or poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHH) [ 44 ] copolymers. Despite the fact that these PHB copolymers have shown higher flexibility, lower melting temperatures and wider processing windows as compared to the pristine PHB [ 46 ], they still have poor mechanical properties or are difficult to be obtained through efficient synthesis processes, which has limited their utilization for commercial use [ 47 ]. A second strategy involves the use of petroleum-based (dioctyl adipate, dioctyl phthalate, dibutyl phthalate, polyethylene glycol, polyadipates etc.)…”

Section: Poly(3-hydroxybutyrate)mentioning

confidence: 99%

Poly(3-hydroxybutyrate) Nanocomposites with Cellulose Nanocrystals

et al. 2022

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Poly(3-hydroxybutyrate) (PHB) is one of the most promising substitutes for the petroleum-based polymers used in the packaging and biomedical fields due to its biodegradability, biocompatibility, good stiffness, and strength, along with its good gas-barrier properties. One route to overcome some of the PHB’s weaknesses, such as its slow crystallization, brittleness, modest thermal stability, and low melt strength is the addition of cellulose nanocrystals (CNCs) and the production of PHB/CNCs nanocomposites. Choosing the adequate processing technology for the fabrication of the PHB/CNCs nanocomposites and a suitable surface treatment for the CNCs are key factors in obtaining a good interfacial adhesion, superior thermal stability, and mechanical performances for the resulting nanocomposites. The information provided in this review related to the preparation routes, thermal, mechanical, and barrier properties of the PHB/CNCs nanocomposites may represent a starting point in finding new strategies to reduce the manufacturing costs or to design better technological solutions for the production of these materials at industrial scale. It is outlined in this review that the use of low-value biomass resources in the obtaining of both PHB and CNCs might be a safe track for a circular and bio-based economy. Undoubtedly, the PHB/CNCs nanocomposites will be an important part of a greener future in terms of successful replacement of the conventional plastic materials in many engineering and biomedical applications.

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“…due to its excellent properties such as absorption capacity, low cytotoxicity, piezoelectricity, and thermoplasticity compared to brittle PHB ( Tan et al, 2014 ; Rivera-Briso and Serrano, 2018 ; Chen et al, 2019 ). As reported by Ibrahim et al (2020) , PHBV is a very promising copolymer that has great potential to replace conventional non-degradable polymers and has a great sustainability potential in circular economy development strategy. For most industrial uses of PHBV, the 3HV fraction should be at least in the range of 10–20% and usually chemical precursors such as propionate and valerate were added to obtain such 3HV fraction ( Hermann-Krauss et al, 2013 ).…”

Section: Introductionmentioning

confidence: 99%

Extremophilic Bacterium Halomonas desertis G11 as a Cell Factory for Poly-3-Hydroxybutyrate-co-3-Hydroxyvalerate Copolymer’s Production

Hammami

Souissi

Souii

et al. 2022

Front. Bioeng. Biotechnol.

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Microbial polyhydroxyalkanoates (PHA) are biodegradable and biocompatible bio-based polyesters, which are used in various applications including packaging, medical and coating materials. In this study, an extremophilic hydrocarbonoclastic bacterium, previously isolated from saline sediment in the Tunisian desert, has been investigated for PHA production. The accumulation of intracellular PHA granules in Halomonas desertis G11 was detected by Nile blue A staining of the colonies. To achieve maximum PHA yield by the strain G11, the culture conditions were optimized through response surface methodology (RSM) employing a Box-Behnken Design (BBD) with three independent variables, namely, substrate concentration (1–5%), inoculum size (1–5%) and incubation time (5–15 days). Under optimized conditions, G11 strain produced 1.5 g/L (68% of DCW) of PHA using glycerol as a substrate. Application of NMR (1H and 13C) and FTIR spectroscopies showed that H. desertis accumulated PHA is a poly-3-hydroxybutyrate-co-3-hydroxyvalerate (PHBV). The genome analysis revealed the presence of typical structural genes involved in PHBV metabolism including phaA, phaB, phaC, phaP, phaZ, and phaR, coding for acetyl-CoA acetyltransferase, acetoacetyl-CoA reductase, class I polyhydroxyalkanoates synthases, phasin, polyhydroxyalkanoates depolymerase and polyhydroxyalkanoates synthesis repressor, respectively. Glycerol can be metabolized to 1) acetyl-CoA through the glycolysis pathway and subsequently converted to the 3HB monomer, and 2) to propionyl-CoA via the threonine biosynthetic pathway and subsequently converted to the 3HV monomer. In silico analysis of PhaC1 from H. desertis G11 indicated that this enzyme belongs to Class I PHA synthase family with a “lipase box”-like sequence (SYCVG). All these characteristics make the extremophilic bacterium H. desertis G11 a promising cell factory for the conversion of bio-renewable glycerol to high-value PHBV.

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Properties and Applications of Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) Biocomposites

Cited by 47 publications

References 188 publications

A promising antimicrobial bionanocomposite based poly(3-hydroxybutyrate-co-3-hydroxyvalerate) reinforced silver doped zinc oxide nanoparticles

A promising antimicrobial bionanocomposite based poly(3-hydroxybutyrate-co-3-hydroxyvalerate) reinforced silver doped zinc oxide nanoparticles

Poly(3-hydroxybutyrate) Nanocomposites with Cellulose Nanocrystals

Extremophilic Bacterium Halomonas desertis G11 as a Cell Factory for Poly-3-Hydroxybutyrate-co-3-Hydroxyvalerate Copolymer’s Production

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