Properties and connections of cat fastigiospinal neurons

Wilson, Victor J.; Uchino, Yuichi; Maunz, R. A.; Susswein, Abraham J.; Fukushima, Kunihiro

doi:10.1007/bf00237385

Cited by 43 publications

(16 citation statements)

References 27 publications

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“…Neurons in the vestibular nerve and nuclei of the rhesus monkey encode motion of the head during passive motion (Roy and Cullen, 2001; Cullen and Minor, 2002), despite early vestibular-neck convergence in sensory processing (Boyle and Pompeiano, 1981; Anastasopoulos and Mergner, 1982; Wilson et al, 1990; Wilson, 1991). The significant convergence of vestibular and proprioceptive inputs within the next stage of processing in the rostral FN nucleus of the cerebellum (Furuya et al, 1975; Wilson et al, 1978; Matsushita and Tanami, 1987; Matsushita and Xiong, 2001), make this area a likely candidate for encoding body motion. Indeed, given that the rostral FN constitutes a major output of the anterior vermis (Verburgh et al, 1989) and nodulus/uvula (Voogd et al, 1996), both of which have been implicated in vestibular-proprioceptive interactions for limb and postural control; our findings suggest that the body motion signals encoded by rostral FN play an important role in the production of accurate motor behaviors.…”

Section: Discussionmentioning

confidence: 99%

Multimodal Integration in Rostral Fastigial Nucleus Provides an Estimate of Body Movement

Brooks¹,

Cullen²

2009

J. Neurosci.

106

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The ability to accurately control posture and perceive self motion and spatial orientation requires knowledge of both the motion of the head and body. However, while the vestibular sensors and nuclei directly encode head motion, no sensors directly encode body motion. Instead, the convergence of vestibular and neck proprioceptive inputs during self-motion is generally believed to underlie the ability to compute body motion. Here, we provide evidence that the brain explicitly computes an internal estimate of body motion at the level of single cerebellar neurons. Neuronal responses were recorded from the rostral fastigial nucleus, the most medial of the deep cerebellar nuclei, during whole-body, body-under-head, and head-on-body rotations. We found that approximately half of the neurons encoded the motion of the body-in-space, while the other half encoded the motion of the head-in-space in a manner similar to neurons in the vestibular nuclei. Notably, neurons encoding body motion responded to both vestibular and proprioceptive stimulation (accordingly termed bimodal neurons). In contrast, neurons encoding head motion were only sensitive to vestibular inputs (accordingly termed unimodal neurons). Comparison of the proprioceptive and vestibular responses of bimodal neurons further revealed similar tuning in response to changes in head-on-body position. We propose that the similarity in nonlinear processing of vestibular and proprioceptive signals underlies the accurate computation of body motion. Furthermore, the same neurons that encode body motion (i.e., bimodal neurons) most likely encode vestibular signals in a body referenced coordinate frame, since the integration of proprioceptive and vestibular information is required for both computations.

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Section: Discussionmentioning

confidence: 99%

Multimodal Integration in Rostral Fastigial Nucleus Provides an Estimate of Body Movement

Brooks¹,

Cullen²

2009

J. Neurosci.

106

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“…The cerebellum asserts control over muscle tone through a relatively direct action on spinal motor neurons and reflex mechanisms (Pompeiano, 1967;Thomas, Kaufman, Sprague, & Chambers, 1956;Wilson, Uchino, Maunz, Susswein, & Fukushima, 1978). At the same time, it influences higher levels of sensorimotor organization through direct inputs to brain· stem postural mechanisms (Brodal, 1957;Sherrington, 1906;Sprague & Chambers, 1953, 1959.…”

mentioning

confidence: 99%

“…The paleocerebellum, as described by Larsell (1934Larsell ( , 1967, includes portions of the anterior lobe and vermal cortex. In addition to interactions with the vestibular system, the paleocerebellum establishes extensive descending connections, directly and via the fastigial nucleus, to widespread areas of the brainstem reticular formation (Bharos, Kuypers, Lemon, & Muir, 1981;Larsell & Jansen, 1972;Martin, King, & Dom, 1974; and to the spinal cord (Batton, Jayaraman, Ruggiero, & Carpenter, 1977;Thomas, Kaufman, Sprague, & Chambers, 1956;Wilson, Uchino, Maunz, Susswein, & Fukushima, 1978). In addition, the paleocerebellum contributes direct and indirect projections to multiple areas within the limbic system (Angaut & Bowsher, 1970;Heath, 1976a;Snider, 1967;.…”

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confidence: 99%

The paleocerebellum and the integration of behavioral function

1982

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The role of the cerebellum in motor function is well documented. Additional data clearly im· plicate the cerebellum in the regulation of sensory processes and autonomic functions, and more recent findings establish an influence of cerebellar systems on the regulation of emotional and motivational behaviors. The cerebellum provides extensive projections to brain· stem and limbic mechanisms that have been implicated in behavioral regulation, and experimen· tal manipulations of the cerebellum have been found to profoundly affect behavioral processes. In the present paper, w~ review some of these findings and offer a conceptual view of cerebellar function that reconciles these apparently disparate actions. We suggest that the cerebellum exerts functionally similar influences at all levels of sensorimotor and behavioral orga· nization. This model provides a conceptual framework for understanding the behavioral consequences of cerebellar dysfunctions, which we suggest can be viewed as behavioral parallels to the classical cerebellar motor syndromes. Data implicating cerebellar systems in the pathogenesis of developmental disturbances in behavioral processes are also considered in the con· text of the present conception of cerebellar·behavioral function.

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“…Second, the rFN is a principle outflow nucleus of the cerebellar vermis, and neurons in the vermal regions of the anterior and posterior cerebellum are responsive to hindlimb movement (Oscarsson 1969; Gray et al 1993). Furthermore, the activity of rFN neurons is modulated during mechanical manipulations of the hindlimb (toe taps and pressure to foot pads) and electrical stimulation of hindlimb nerves (Eccles et al 1974a; Eccles et al 1974b; Wilson et al 1978). Third, rFN neuronal activity is modulated by vestibular afferent activation (Ghelarducci 1973; Ghelarducci et al 1974; Stanojevic et al 1980; Stanojevic 1981; Siebold et al 1997; Shaikh et al 2005; Miller et al 2008).…”

Section: Introductionmentioning

confidence: 99%

Hindlimb movement modulates the activity of rostral fastigial nucleus neurons that process vestibular input

et al. 2015

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Integration of vestibular and proprioceptive afferent information within the central nervous system is a critical component of postural regulation. We recently demonstrated that labyrinthine and hindlimb signals converge onto vestibular nucleus neurons, such that hindlimb movement modulates the activity of these cells. However, it is unclear whether similar convergence of hindlimb and vestibular signals also occurs upstream from the vestibular nuclei, particularly in the rostral fastigial nucleus (rFN). We tested the hypothesis that rFN neurons have similar responses to hindlimb movement as vestibular nucleus neurons. Recordings were obtained from 53 rFN neurons that responded to hindlimb movement in decerebrate cats. In contrast to vestibular nucleus neurons, which commonly encoded the direction of hindlimb movement (81% of neurons), few rFN neurons (21%) that responded to leg movement encoded such information. Instead, most rFN neurons responded to both limb flexion and extension. Half of the rFN neurons whose activity was modulated by hindlimb movement received convergent vestibular inputs. These results show that rFN neurons receive somatosensory inputs from the hindlimb, and that a subset of rFN neurons integrates vestibular and hindlimb signals. Such rFN neurons likely perform computations that participate in maintenance of balance during upright stance and movement. Although vestibular nucleus neurons are interconnected with the rFN, the dissimilarity of responses of neurons sensitive to hindlimb movement in the two regions suggest that they play different roles in coordinating postural responses during locomotion and other movements which entail changes in limb position.

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Properties and connections of cat fastigiospinal neurons

Cited by 43 publications

References 27 publications

Multimodal Integration in Rostral Fastigial Nucleus Provides an Estimate of Body Movement

Multimodal Integration in Rostral Fastigial Nucleus Provides an Estimate of Body Movement

The paleocerebellum and the integration of behavioral function

Hindlimb movement modulates the activity of rostral fastigial nucleus neurons that process vestibular input

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