Properties and Mechanism of Hydroxyapatite Coating Prepared by Electrodeposition on a Braid for Biodegradable Bone Scaffolds

Li, Ting‐Ting; Ling, Lei; Lin, Mei‐Chen; Jiang, Qian; Lin, Qi; Lin, Jia‐Horng; Lou, Ching‐Wen

doi:10.3390/nano9050679

Cited by 42 publications

(37 citation statements)

References 46 publications

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“…The two peaks around 1448 and 1373 cm −1 correspond to the methyl groups of the PLA-PVA bioscaffolds. Moreover, the high-intensity peak that is positioned at 3399 cm −1 corresponds to the stretching vibration of the oxygen-hydrogen bond (O-H) [ 12 , 42 , 43 ]. Figure 2 A, illustrates that the intensity and position of the absorption peak of the hydroxyl group changed with the addition of salts and thermal treatment.…”

Section: Resultsmentioning

confidence: 99%

Polylactide/Polyvinylalcohol-Based Porous Bioscaffold Loaded with Gentamicin for Wound Dressing Applications

et al. 2021

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: This study explores the feasibility of modifying the surface liquid spraying method to prepare porous bioscaffolds intended for wound dressing applications. For this purpose, gentamicin sulfate was loaded into polylactide-polyvinyl alcohol bioscaffolds as a highly soluble (hygroscopic) model drug for in vitro release study. Moreover, the influence of inorganic salts including NaCl (10 g/L) and KMnO4 (0.4 mg/L), and post-thermal treatment (T) (80 °C for 2 min) on the properties of the bioscaffolds were studied. The bioscaffolds were characterized by scanning electron microscopy, Fourier Transform infrared spectroscopy, and differential scanning calorimetry. In addition, other properties including porosity, swelling degree, water vapor transmission rate, entrapment efficiency, and the release of gentamicin sulfate were investigated. Results showed that high concentrations of NaCl (10 g/L) in the aqueous phase led to an increase of around 68% in the initial burst release due to the increase in porosity. In fact, porosity increased from 68.1 ± 1.2 to 94.1 ± 1.5. Moreover, the thermal treatment of the Polylactide-polyvinyl alcohol/NaCl (PLA-PVA/NaCl) bioscaffolds above glass transition temperature (Tg) reduced the initial burst release by approximately 11% and prolonged the release of the drug. These results suggest that thermal treatment of polymer above Tg can be an efficient approach for a sustained release.

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Section: Resultsmentioning

confidence: 99%

Polylactide/Polyvinylalcohol-Based Porous Bioscaffold Loaded with Gentamicin for Wound Dressing Applications

et al. 2021

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“…Hydroxyapatite (HA) Ca 10 (PO 4 ) 6 OH 2 is an inorganic material that is present as a natural component of human teeth and bones. Biocompatibility and biological inertia, as well as nanotechnology development [19], make HA the scaffold of choice for drug delivery [20].…”

Section: Introductionmentioning

confidence: 99%

An Innovative Approach to Control H. pylori-Induced Persistent Inflammation and Colonization

et al. 2020

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Helicobacter pylori (H. pylori) is a Gram-negative bacterium which colonizes the human stomach. The ability of H. pylori to evade the host defense system and the emergence of antibiotic resistant strains result in bacteria persistence and chronic inflammation, which leads to both severe gastric and extra-gastric diseases. Consequently, innovative approaches able to overcome H. pylori clinical outcomes are needed. In this work, we develop a novel non-toxic therapy based on the synergistic action of H. pylori phage and lactoferrin adsorbed on hydroxyapatite nanoparticles, which effectively impairs bacteria colonization and minimizes the damage of the host pro-inflammatory response.

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“…Additionally, electrodeposition offers a higher degree of tailoring than plasma spraying; morphology and coating thickness can be modified in a controlled manner by varying the deposition parameters such as temperature, potential, and electrolyte. Successful synthesis of HAp coatings via the electrodeposition method has been reported for various porous substrates [41][42][43][44]. However, to date, there are no reports of HAp being electrodeposited onto 3D metallic weaves.…”

Section: Introductionmentioning

confidence: 99%

Electrodeposition of Hydroxyapatite on a Metallic 3D-Woven Bioscaffold

et al. 2020

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In this study, we demonstrate that a uniform coating of hydroxyapatite (HAp, Ca10(PO4)6(OH)2) can be electrochemically deposited onto metallic 3D-woven bone scaffolds to enhance their bioactivity. The HAp coatings were deposited onto metallic scaffolds using an electrolyte containing Ca(NO3)2·4H2O, NH4H2PO4, and NaNO3. The deposition potential was varied to maximize the uniformity and adhesion of the coating. Using X-ray diffraction (XRD), Raman spectroscopy, and energy-dispersive spectroscopy (EDS), we found crystallized HAp on the 3D-woven lattice under all deposition potentials, while the −1.5 V mercury sulfate reference electrode potential provided the best local uniformity with a satisfactory deposition rate. The coatings generated under this optimized condition were approximately 5 µm thick and uniform throughout the internal and external sections of the woven lattice. We seeded and cultured both coated and uncoated scaffolds with human adipose-derived stromal/stem cells (ASCs) for 12 h and 4 days. We observed that the HAp coating increased the initial cell seeding efficiency by approximately 20%. Furthermore, after 4 days of culture, ASCs cultured on HAp-coated stainless-steel scaffolds increased by 32% compared to only 17% on the uncoated scaffold. Together, these results suggest that the HAp coating improves cellular adhesion.

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Properties and Mechanism of Hydroxyapatite Coating Prepared by Electrodeposition on a Braid for Biodegradable Bone Scaffolds

Cited by 42 publications

References 46 publications

Polylactide/Polyvinylalcohol-Based Porous Bioscaffold Loaded with Gentamicin for Wound Dressing Applications

Polylactide/Polyvinylalcohol-Based Porous Bioscaffold Loaded with Gentamicin for Wound Dressing Applications

An Innovative Approach to Control H. pylori-Induced Persistent Inflammation and Colonization

Electrodeposition of Hydroxyapatite on a Metallic 3D-Woven Bioscaffold

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