Properties and Use of Microreactors

Barrow, David A.; Taylor, Shan; and, Alex Morgan; Giles, Lily

doi:10.1002/9783527659722.ch1

Cited by 6 publications

(1 citation statement)

References 139 publications

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“…One of the main reasons for its emergence and popularity is the ability to significantly improve the safety of batch reactions . Improved reagent mixing, heat and mass transfer but also increased reproducibility, scale-up, and automated synthetic operations explain the growing interest in this field. − Sensitive and toxic reaction intermediates can be generated and directly consumed in a single process without intermediate handling or hazardous material storage.…”

Section: Introductionmentioning

confidence: 99%

Efficient Transposition of the Sandmeyer Reaction from Batch to Continuous Process

D'Attoma

Camara

Brun

et al. 2016

Org. Process Res. Dev.

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The transposition of Sandmeyer chlorination from a batch to a safe continuous-flow process was investigated. Our initial approach was to develop a cascade method using flow chemistry which involved the generation of a diazonium salt and its quenching with copper chloride. To achieve this safe continuous process diazotation, a chemometric approach (Simplex method) was used and extrapolated to establish a fully continuous-flow method. The reaction scope was also examined via the synthesis of several (het)aryl chlorides. Validation and scale-up of the process were also performed. A higher productivity was obtained with increased safety.

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Section: Introductionmentioning

confidence: 99%

Efficient Transposition of the Sandmeyer Reaction from Batch to Continuous Process

D'Attoma

Camara

Brun

et al. 2016

Org. Process Res. Dev.

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Development of Enzymatic Reactions in Miniaturized Reactors

Honda

Yamaguchi

Miyazaki

2017

Applied Bioengineering

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A Rapid Total Synthesis of Ciprofloxacin Hydrochloride in Continuous Flow

et al. 2017

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Within at otal residence time of 9min, the sodium salt of ciprofloxacin was prepared from simple building blocks via al inear sequence of six chemical reactions in five flow reactors.S equential offline acidifications and filtrations afforded ciprofloxacin and ciprofloxacin hydrochloride.T he overall yield of the eight-step sequence was 60 %. No separation of intermediates was required throughout the synthesis when as ingle acylation reaction was applied to remove the main byproduct, dimethylamine.

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Properties and Use of Microreactors

Cited by 6 publications

References 139 publications

Efficient Transposition of the Sandmeyer Reaction from Batch to Continuous Process

Efficient Transposition of the Sandmeyer Reaction from Batch to Continuous Process

Development of Enzymatic Reactions in Miniaturized Reactors

A Rapid Total Synthesis of Ciprofloxacin Hydrochloride in Continuous Flow

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