Properties of arginase from the foot muscle of Chiton latus

Carvajal, Nelson; Kessi, Eduardo; Bidart, Juan Esteban; Rojas, Andrés Romero

doi:10.1016/0305-0491(88)90092-2

Cited by 9 publications

(8 citation statements)

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“…Arginase is activated by cadmium ion in tissue extracts from different organisms such as hepatopancreas of land snail [12], silk moth [13], bovine brain [14], rat liver, kidney, submaxillary gland, and brain [15,16], frog liver [17], sea mollusk Chiton latus [18] and bivalve clam Semele solida [19]. However, arginase is inhibited by cadmium ion in tissue extracts from axolotl liver [20], lupin [21], rat kidney [22], rat small intestine [23], barnacle rock shell Concholepas concholepas [24], common bean Phaseolus vulgaris [25] and zebra mussel Dreissena polymorpha [26].…”

Section: Introductionmentioning

confidence: 99%

Inhibition of rat liver and kidney arginase by cadmium ion

Tormanen

2006

Journal of Enzyme Inhibition and Medicinal Chemistry

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Cadmium ion activates arginase from many species of organisms but is an inhibitor of arginase from many other species. The purpose of this study was to investigate the inhibition of rat liver and kidney arginase by cadmium ion. Rat kidney arginase was inhibited by much lower concentrations of cadmium ion than rat liver arginase. Cadmium ion was a mixed noncompetitive inhibitor of both rat liver and kidney arginase. Cadmium ion enhanced the substrate activation of rat kidney arginase while still inhibiting the enzyme. Cadmium ion prevented the substrate inhibition of rat kidney arginase by fluoride while still inhibiting the enzyme. Cadmium ion also inhibited rat kidney arginase in the presence of manganese ion.

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Section: Introductionmentioning

confidence: 99%

Inhibition of rat liver and kidney arginase by cadmium ion

Tormanen

2006

Journal of Enzyme Inhibition and Medicinal Chemistry

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“…On the other hand, the foot muscle arginase was also activated by Co 2+ , the same activation was not observed in gills tissue (Figure 3a, b). Cations like Co 2+ have also been reported to activate some arginases, Carvajal et al (1984Carvajal et al ( , 1988 Tormanen (1997) observed the same activation in arginase of Zebra mussel.…”

Section: +mentioning

confidence: 60%

“…At subcellular level, the cytosol concentrates most of the arginase activity, both in gills (99%) and foot muscle (86.4%). Carvajal et al (2004) and the inhibition by substrate L-arginine are similar to the arginase of polyplacophoran Chiton latus, which also has relatively high levels of arginase activity in the foot muscle and gills (Carvajal et al 1988). Tormanen (1997) also observed arginase inhibition with high concentrations of substrate L-arginine in Zebra mussel.…”

Section: Resultsmentioning

confidence: 81%

“…It is also present in soils near stations which have used brass, steel coated nails and paints (Claridge et al, 1995;Webster et al, 2003), leaching of volcanic rocks also results in high levels of Fe 3+ and Zn 2+ (Ahn et al, 1999;Weihe et al, 2010 (Figure 4a, b). Carvajal et al (1984Carvajal et al ( , 1988Carvajal et al ( , 1994) observed inhibition of arginases by Zn 2+ in gills and foot muscle of…”

Section: +mentioning

confidence: 99%

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Arginase kinetic characterization of the gastropod Nacella concinna and its physiological relation with energyrequirement demand and the presence of heavy metals

Rodrigues¹,

Lavrado²,

Donatti³

et al. 2010

INCT-APA

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“…High levels of this enzyme were found in the gills of marine mollusks such as the gastropod Concholepas concholepas and the bivalve Semele solida (Carvajal et al 1984, Carvajal et al 1994, whereas, in others, such as the marine polyplacophoran Chiton latus, the argininolitic activity is concentrated in the gills and the muscular foot (Carvajal et al 1988).…”

Section: Nitrogen Metabolismmentioning

confidence: 99%

NITROGEN METABOLISM OF THE ANTARCTIC BIVALVE Laternula elliptica (KING & BRODERIP) AND ITS POTENTIAL USE AS BIOMARKER

2007

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The Antarctic marine environment is characterized by the extreme seasonality of the primary production in the water column and the low but stable temperatures. Both are considered the main factors in the adaptative evolution of Antarctic ectothermic organisms. Studies about physiological and biochemical processes of the cold-adapted species revealed the presence of antifreeze glycoproteins in the biological fluids and cold-adapted proteins. The low and stable temperatures have resulted in the appearence of enzymes with high catalytic efficiency and the absence of the thermal stress proteins in some Antarctic fishes. The austral winter promotes a seasonal food shortage, submitting the benthic ectotherms to long periods of starvation. This is particularly true for the organisms that depend on phytoplankton as their primary source of food. The Antarctic marine environment also presents areas of high copper concentrations on the sediment surface as well as cadmium in the water column. The bivalve Laternula elliptica, a circumpolar species, has been proposed as bioindicator for long term monitoring of heavy metals in the shallow waters of Antarctica due to its capacity to accumulate metals, especially cadmium and zinc. Like other Antarctic ectothermic organisms, L. elliptica changes its metabolism from aerobic to anaerobic as a function of temperature, being 6 ºC critical and 9 ºC lethal. This bivalve also shows a marked seasonality in its metabolism, with low oxygen consumption in winter as compared to summer. It is speculated that it enters into a dormancy state during the austral winter as it apparently retracts its siphons below the sediment surface. The apparent supression of the water pumping by the siphons during winter forces L. elliptica to mobilize its energy reserves, using the siphon proteins as its principal source of energy (ratio of oxygen consumption/excreted nitrogen = 3.0). Even during summer, when the high food supply stimulates the bivalve growth, the metabolism is mainly protein based. (O:N ratio = 16). The excretory nitrogen metabolism of this bivalve is typically ammoniotelic, characterized by the excretion of almost 90% of nitrogen in the form of ammonia and 10% as urea. Probably, the urea excreted arises from the hydrolysis of the proteic aminoacid L-arginine by arginase in order to maintain the tissue levels of that aminoacid. In such case, the presence of this enzyme in the kidney tissues may be related to the physiological constraints caused by the retraction of the siphons and the requirements for the excretion of this nitrogen compound during the austral winter. Studies with the renal arginase of this bivalve showed a high metabolic tolerance to the metallic cations Cu, Zn, Fe and Cd, when compared to the arginase behavior of other bivalves such as Dreissena polymorpha. The present work covers the life history of this bivalve, its potential use as a biomarker and its adaptations to the extreme marine environment conditions in Antarctica. Key-words: Antarctica, benthos, Laternula ...

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Properties of arginase from the foot muscle of Chiton latus

Cited by 9 publications

References 16 publications

Inhibition of rat liver and kidney arginase by cadmium ion

Inhibition of rat liver and kidney arginase by cadmium ion

Arginase kinetic characterization of the gastropod Nacella concinna and its physiological relation with energyrequirement demand and the presence of heavy metals

NITROGEN METABOLISM OF THE ANTARCTIC BIVALVE Laternula elliptica (KING & BRODERIP) AND ITS POTENTIAL USE AS BIOMARKER

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Properties of arginase from the foot muscle of Chiton latus

Cited by 9 publications

References 16 publications

Inhibition of rat liver and kidney arginase by cadmium ion

Inhibition of rat liver and kidney arginase by cadmium ion

Arginase kinetic characterization of the ­gastropod Nacella concinna and its ­physiological relation with energy­requirement demand and the presence of heavy metals

NITROGEN METABOLISM OF THE ANTARCTIC BIVALVE Laternula elliptica (KING & BRODERIP) AND ITS POTENTIAL USE AS BIOMARKER

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Arginase kinetic characterization of the gastropod Nacella concinna and its physiological relation with energyrequirement demand and the presence of heavy metals