Properties of Bacillus acidocaldarius mutants deficient in ?-cyclohexyl fatty acid biosynthesis

Krischke, Wolfgang; Poralla, Karl

doi:10.1007/bf00248428

Cited by 27 publications

(15 citation statements)

References 27 publications

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“…Its mutants, prepared by ethyl methanesulfate treatment, could be grown by supplementation with branched-chain amino acids and cyclohexanecarboxylic acid; they produced branched-chain fatty acids and w-cyclohexyl fatty acids, respectively, as major cellular fatty acids. Cultures of the mutants grown in the medium supplemented with cyclohexanecarboxylic acid always gave a higher yield of cells, grew at a higher temperature and a lower pH, and had a higher transport activity than those grown with branched-chain amino acids (88).…”

Section: Function Of Branched-chain Fatty Acidsmentioning

confidence: 94%

Iso- and anteiso-fatty acids in bacteria: biosynthesis, function, and taxonomic significance.

Kaneda¹

1991

Microbiological Reviews

832

444

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Section: Function Of Branched-chain Fatty Acidsmentioning

confidence: 94%

Iso- and anteiso-fatty acids in bacteria: biosynthesis, function, and taxonomic significance.

Kaneda¹

1991

Microbiological Reviews

832

444

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“…This phenotype has been induced and studied in a B. subtilis mutant, strain bfm 49. When this auxotroph was grown in the presence of cyclic fatty acid precursors (14), the formation of w-alicyclic fatty acids was induced so that the fatty acid composition of strain bfm 49 resembled the fatty acid composition found in B. acidocaldarius (25). However, strain bfm 49 did not grow thermophilically at 47°C or under acidophilic conditions at pH 5.0.…”

Section: Over the Past Two Decades Several Unusual Thermoacidophilic mentioning

confidence: 99%

Comparative Sequence Analyses on the 16S rRNA (rDNA) of Bacillus acidocaldarius, Bacillus acidoterrestris, and Bacillus cycloheptanicus and Proposal for Creation of a New Genus, Alicyclobacillus gen. nov.

Wisotzkey

Jurtshuk

Fox

et al. 1992

International Journal of Systematic Bacteriology

Self Cite

402

256

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Comparative 16s rRNA (rDNA) sequence analyses performed on the thermophilic Bacillus species Bacillus acidocaldarius, Bacillus acidoterrestris, and Bacillus cycloheptanicus revealed that these organisms are sufficiently different from the traditional Bacillus species to warrant reclassification in a new genus, Alicyclobacillus gen. nov. An analysis of 16s rRNA sequences established that these three thermoacidophiles cluster in a group that differs markedly from both the obligately thermophilic organism Bacillus stearothermophilus and the facultatively thermophilic organism Bacillus coagulans, as well as many other common mesophilic and thermophilic Bacillus species. The thermoacidophilic Bacillus species B. acidocaldarius, B. acidoterrestris, and B. cycloheptanicus also are unique in that they possess w-alicylic fatty acid as the major natural membranous lipid component, which is a rare phenotype that has not been found in any other Bacillus species characterized to date. This phenotype, along with the 16s rRNA sequence data, suggests that these thermoacidophiles are biochemically and genetically unique and supports the proposal that they should be reclassified in the new genus Alicyclobacillus.

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“…A. acidoterrestris contains ω-cyclohexyl fatty acids in its cellular membrane composition. These ring structures are of special physiological importance for cells at a high growth temperature and low pH (Kirschke and Poralla, 1990).…”

Section: Introductionmentioning

confidence: 99%

Germination and Inactivation of Alicyclobacillus acidoterrestris Spores Induced by Moderate Hydrostatic Pressure

Sokołowska¹,

Skąpska²,

Fonberg-Broczek³

et al. 2015

Pol J Microbiol

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Neisseria meningitidis is a commensal of human nasopharynx and humans are the only known reservoir and host of this bacterium. It is also known as a dangerous and devastating pathogen, and infection with N. meningitidis may lead to rapidly progressing septicemia or meningitis. These severe infections, called invasive meningococcal disease (IMD), are one of the major public health threats worldwide. IMD may occur sporadically, but also in outbreaks, epidemics, and pandemics. Most of the IMD cases in the world are caused by isolates of genetically related groups, clonal complexes (CC), including those with special epidemiological significance called hyperinvasive clonal complexes. It is still unknown why some of them may persist for decades, whereas other are quickly replaced and disappear. As a consequence, the epidemiological situation of IMD is variable worldwide and greatly depends on the emergence and widespread of clones belonging to hyperinvasive clonal complexes. Their occurrence has serious implications for health policy, requiring often mass immunization campaigns. Paradoxically, alarming situations caused by hyperinvasive CCs stimulated the development and introduction of new vaccines against meningococci. Despite the unquestionable success of these vaccines, isolates of hyperinvasive clones constitute a permanent public health threat, because they are constantly circulating and able to modify their antigenic profiles to escape the host immune response. Therefore, continuous monitoring of meningococcal isolates including thorough molecular typing is indispensable and fundamental for taking appropriate preventive measures.

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Properties of Bacillus acidocaldarius mutants deficient in ?-cyclohexyl fatty acid biosynthesis

Cited by 27 publications

References 27 publications

Iso- and anteiso-fatty acids in bacteria: biosynthesis, function, and taxonomic significance.

Iso- and anteiso-fatty acids in bacteria: biosynthesis, function, and taxonomic significance.

Comparative Sequence Analyses on the 16S rRNA (rDNA) of Bacillus acidocaldarius, Bacillus acidoterrestris, and Bacillus cycloheptanicus and Proposal for Creation of a New Genus, Alicyclobacillus gen. nov.

Germination and Inactivation of Alicyclobacillus acidoterrestris Spores Induced by Moderate Hydrostatic Pressure

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