Properties of biomedical pressure‐sensitive adhesive copolymer films with pendant monosaccharides

Miyata, Takashi; Morizane, Mayumi; Nakamae, Katsuhiko; Okumura, Masakazu; Kinomura, Keisuke

doi:10.1002/app.1995.070561212

Cited by 10 publications

(8 citation statements)

References 25 publications

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“…52 We synthesized a variety of carbohydrate polymers by copolymerizing a monomer with pendant glucose (2-glucosyloxyethyl methacrylate: GEMA) and hydrophilic or hydrophobic monomers and examined their unique surface properties under various conditions. [53][54][55][56][57][58] Furthermore, complex formation between Con.A and polymers with pendant glucose (PGEMA) was investigated to design a glucose-responsive polymer. 59 When Con.A was added to a buffer solution containing PGEMA, the solution became turbid due to multiple associations between PGEMA and Con.A.…”

Section: Glucose-responsive Hydrogelsmentioning

confidence: 99%

Preparation of smart soft materials using molecular complexes

Miyata

2010

Polym J

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This article provides a short overview of our research regarding the preparation of smart soft materials using molecular complexes that reversibly associate and dissociate in response to environmental changes. Stimuli-responsive hydrogels that show swelling/shrinking in response to pH and temperature were prepared by copolymerization of a monomer bearing a phosphate group and other various monomers. Hydrogels with phosphate groups were useful tools for the construction of self-regulated drug delivery systems. Furthermore, we proposed a strategy for the preparation of biomolecule-responsive hydrogels that use reversible crosslinks in the networks of biomolecular complexes. Based on this strategy, we have prepared two types of biomolecule-responsive hydrogel that undergo changes in volume in response to target biomolecules. This was accomplished using biomolecular complexes such as antigen-antibody complexes and saccharide-lectin complexes and both a biomolecule-crosslinked hydrogel and a biomolecule-imprinted hydrogel have been synthesized with this approach. Biomolecule-crosslinked hydrogels, such as glucose-and antigen-responsive hydrogels, swelled in the presence of a target biomolecule due to the dissociation of biomolecular complexes that act as reversible crosslinks. On the other hand, biomolecule-imprinted hydrogels, such as tumor marker glycoprotein-responsive hydrogels, shrank in response to a target biomolecule due to the formation of a complex between ligands (lectin and antibody) and the target biomolecule. Thus, biomolecule-responsive hydrogels have many potential applications as smart biomaterials in biomedical fields. Although most smart soft materials prepared using molecular complexes still require further research, they are likely to become important materials in the future.

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Section: Glucose-responsive Hydrogelsmentioning

confidence: 99%

Preparation of smart soft materials using molecular complexes

Miyata

2010

Polym J

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“…Pressure sensitive adhesives (PSAs) have been utilized in a range of medical applications, from low-tech pressure tapes to high-tech implant adhesives [1][2][3]. Acrylic resins, synthesized in organic solvents, are the most widely used types of PSA for medical applications, due to their simplicity of manufacture, favorable biocompatibility and good skin adhesion [4].…”

Section: Introductionmentioning

confidence: 99%

Determination of Residual Monomers in Synthesized Acrylic PSAs by Gas Chromatography

Sun

Zhu

et al. 2010

Journal of Adhesion Science and Technology

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The harmful residual monomers present in acrylic pressure sensitive adhesives (PSAs), used in transdermal drug delivery system (TDDS), should be quantified through a simple, rapid and accurate method. This paper introduces an optimized method for the determination of the residual monomers in acrylic polymers based on a gas chromatographic (GC) technique. Acetone was shown to be the optimum extraction solvent and the extraction time was 80 min. The recovery, precision, accuracy, limit of detection (LOD) and limit of quantification (LOQ) of the method were also studied. The method was relatively accurate and precise with recoveries ranging from 93.2 to 102.7% for each monomer with a relative standard deviation of (%RSD) < 7%. The method proposed in this paper for the determination of residual monomers in solventbased acrylic PSAs is simple, accuracy and easy to carry out.

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“…Hydrogels consisting of polymer networks and water have a variety of unique properties;1 for example, they can absorb a large amount of water and some organic compounds. In addition, some hydrogels undergo volume changes in response to external stimuli such as pH,2, 3 temperature,4–8 and signal molecules 9–17. Therefore, hydrogels have many potential applications as smart soft‐materials for constructing drug delivery systems, specific molecule sensing systems, and valuable compound recovery systems.…”

Section: Introductionmentioning

confidence: 99%

Fluorescence resonance energy transfer by quencher adsorption into hydrogels containing fluorophores

Okawa

Miyata

Uragami

2006

J Polym Sci B Polym Phys

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We synthesized anionic hydrogels containing fluorophores and investigated the adsorption of a cationic quencher having an amino group into hydrogels by fluorescence resonance energy transfer (FRET). FRET from the fluorophore to the quencher in hydrogels was examined by fluorescence intensity and fluorescence decay using a fluorescence spectrophotometer and femtosecond laser spectroscopy. The fluorescence intensity of the fluorophore-containing hydrogels decreased rapidly with increasing amounts of adsorbed cationic quencher. The fluorescence emission of the fluorophore in the quencheradsorbed hydrogels containing fluorophores decayed more rapidly than that of the original hydrogels. The aforementioned result indicates that the fluorescence of the fluorophorecontaining hydrogels is quenched due to FRET from the fluorophore to the quencher as the cationic quenchers can approach the fluorophores in hydrogels by electrostatic interactions.

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Properties of biomedical pressure‐sensitive adhesive copolymer films with pendant monosaccharides

Cited by 10 publications

References 25 publications

Preparation of smart soft materials using molecular complexes

Preparation of smart soft materials using molecular complexes

Determination of Residual Monomers in Synthesized Acrylic PSAs by Gas Chromatography

Fluorescence resonance energy transfer by quencher adsorption into hydrogels containing fluorophores

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