Properties of films obtained from biopolymers of different origins for skin lesions therapy

Abstract

In this study, the effects of the origin of xanthan used, in combination with

Analysis of the performance of polysaccharide membranes in aqueous media as a tool to assist wound‐dressing selection

“…The Ch-X membranes presented a higher mass loss in water compared to SS, PBS, and SBF solutions, as observed by Bellini et al 40 Because this formulation had a high water-uptake capacity, the polymeric chains became more flexible because of the great amount of water in the structure, which facilitated mass transfer. The Ch-G membranes presented a high stability in all media, except FBS.…”

“…Bellini et al 40 produced Ch-X membranes with xanthan from two different sources, the first commonly used as an additive in food processing and the second produced in a local pilot plant. The aspects and the morphologies of the membranes obtained were similar to those observed for the membranes of this formulation in this study.…”

“…Thus, the M/G ratio, sequence of groups, and molecular weight of alginate are critical factors affecting the physical properties of this polymer and the resulting hydrogels. 20,23,40,41 Rodrigues et al 19 evaluated the activity of chitosan and alginate membranes against Staphylococcus aureus and Pseudomonas aeruginosa and reported an absence of antibacterial activity. 36,37 Stable mixtures of chitosan can also be attained through physical interactions with neutral polysaccharides such as guar gum.…”

“…Previous studies have shown that membranes of chitosan combined with alginate, xanthan, or guar gum present a very low cytotoxicity against L929 cells. 20,23,40,41 Rodrigues et al 19 evaluated the activity of chitosan and alginate membranes against Staphylococcus aureus and Pseudomonas aeruginosa and reported an absence of antibacterial activity. However, no bacterial permeation through the membranes was observed; this granted the membranes with barrier properties.…”

“…Bierhalz and Moraes 52 and Bierhalz et al53 reported values of 67.43 and 70.09 MPa, respectively, for T and E values of 4.38 and 3.81%, respectively. Bellini et al40 reported T values of about 12.7 and 15.7 MPa and an E value of 2.1% for Ch-X dry membranes prepared with xanthan from different sources. Lower values (5.2 MPa and 1.8%, respectively) were mentioned, although they were for Ch-X membranes 44 stored under the same conditions.…”