In this paper, we study the notions of Browder operator and Browder S-spectrum of bounded right linear operator defined over the right quaternionic Hilbert space. Some properties of Browder operator and stability of the ascent, descent and Browder S-spectrum have been investigated in the right quaternionic setting. We also characterize the property of invariant Browder operators and study the spectral mapping theorem of Browder S-spectrum for self-adjoint operators in quaternionic setting. This investigation concludes by exploring the Browder S-spectrum of the sum of two bounded linear operators.