Properties of High Boiling Petroleum Products. Carcinogenicity Studies.

Dietz, W. A.; King, W. H.; Priestley, W.; Rehner, John

doi:10.1021/ie50512a033

Cited by 16 publications

(5 citation statements)

References 2 publications

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“…The following equation takes number of substituents into account for benzenes and naphthalenes: Ra 0.052F(6,M) 1 + 0.0&S + 0.55 (6) where S is the number of substituents. When the number of aromatic rings is recalculated on these compounds, making use of Equation 6, most of the deviations (also shown in Table II) are so small that they may reflect only the experimental uncertainty in specific dispersion measurements.…”

Section: Testing Of Methods On Individual Hydrocarbonsmentioning

confidence: 99%

“…Isolated polybenzenes are difficult to distinguish in the ultra-6ROMATIC RINGS FROM ELEMENTAL ANALYSES Figure Small quantities of conjugated dibenzenes have been indicated in some petroleum fractions (1), and small quantities of anthracenes in some cracked products (6,31). These quantities are too small, in general, to affect a method based upon density and specific dispersion.…”

mentioning

confidence: 99%

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Determination of Aromatic and Naphthene Rings in Aromatics from Petroleum Fractions

Martin¹,

Sankin²

1953

Anal. Chem.

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Section: Testing Of Methods On Individual Hydrocarbonsmentioning

confidence: 99%

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confidence: 99%

Determination of Aromatic and Naphthene Rings in Aromatics from Petroleum Fractions

Martin¹,

Sankin²

1953

Anal. Chem.

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“…from 101 treated with 8 lb. 98% HaSOi/bbl.a The sample numbers employed in this paper correspond to similar sample numbers in previous publications(4)(5)(6)14)• 1 Coal tar is the only nonpetroleum sample listed.…”

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confidence: 86%

Properties of High Boiling Petroleum Products

Eby¹,

Priestley²,

Rehner³

et al. 1953

Anal. Chem.

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ANDThe only methods heretofore described for predicting carcinogenic activity have been limited to series of pure aromatic compounds or to high]>-specialized types of petroleum products. After examination of a number of different reactions and properties of polycyclic aromatic compounds, five nonbiological methods have been developed for the prediction of tumor potency of high boiling petroleum products. Each method gave about the same degree of correlation with biological data. These physical-chemical methods are all based upon measurements of certain types of polycyclic aromatic hydrocarbons. The results support the premise t h a t the carcinogenicity is a function qf the concentration of these types of compounds in oils. The methods, therefore, obviate the necessity of isolating or analyzing the actual carcinogenic compounds. The caffeine number method is preferred for routine analytical work. It is based upon a n ultraviolet examination of a n aqueous caffeine extract of the aromatic hydrocarbons. A standard deviation of 8.4 was obtained for the difference between the predicted and the biological tumor potency values of 123 different products. Reproducibility of the caffeine number was better than t h a t of the biological data. Comprehensive analytical data for all five methods are presented for a variety of high boiling petroleum products. These demonstrate t h a t a choice of methods is available, depending upon the particular types of products to be analyzed and the facilities a t hand.

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“…Polynuclear aromatic hydrocarbon components appear to be mainly if not entirely responsible for the carcinogenicity of high boiling catalvtically cracked stocks (6). Hydrogenation would therefore be expected to reduce the carcinogenicity of such stocks since hydrogenation, if carried far enough, usually reduces or destroys the potency of carcinogenic polynuclear hydrocarbons (1, 8).…”

Section: Hydrogenationmentioning

confidence: 99%