Properties of Human Serum Factors Precipitating Bovine Enterovirus

Abstract

SUMMARY :We investigated the nature of a normal human serum factor (s) precipitating bovine enterovirus, and obtained the following results.(1) The incidence of the precipitating factor in human serum increased greatly at the ages between 2-5. (2) The precipitating factors in most of the sera examined were identified as IgG globulin.(3) A bovine enterovirus was found to possess two distinct antigens resembling N (native) and H (heat stable) antigens of human enteroviruses ; normal human serum reacted exclusively with the latter . (4) The majority of human sera precipitating heat stable antigen of bovine enterovirus also reacted with the same antigens of human enteroviruses, coxsackievirus B1, coxsackievirus B5 and echovirus type 1. (5) Absorption experiments of human serum with heated viruses indicated the presence of a common antigen (s) between the heat stable antigen of bovine enterovirus and those of coxsackie-and echoviruses, while no serological relationship was found between the heat stable antigen of bovine enterovirus and those of polioviruses.From these results it was presumed that the human serum factor precipitating bovine enterovirus is possibly an antibody produced by infection with coxsackie or echoviruses sharing a common antigen (s) with bovine enterovirus.