Properties of immobilized guinea pig hindlimb muscles

Maier, AB; Crockett, J.L.; Simpson,; Cw, IV Saubert; Edgerton, V. Reggie

doi:10.1152/ajplegacy.1976.231.5.1520

Cited by 92 publications

(30 citation statements)

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“…Similar significant reductions in muscle mass were observed in guinea pig muscle after immobilisation for 28 days (Maier et al, 1976). Hibernation caused significant atrophy in the muscles of golden-mantled ground squirrels Spermophilus lateralis (Wickler et al, 1991a), big brown bats Eptesiscus fuscus (Yacoe, 1983) and hamsters (Wickler et al, 1987).…”

Section: Muscle Morphologysupporting

confidence: 63%

“…Based on the results of previous studies (e.g. Booth and Kelso, 1973;Maier et al, 1976;Tomanek and Lund, 1974) we had predicted that the predominantly oxidative iliofibularis muscle would be more susceptible to muscle disuse atrophy than the glycolytic sartorius muscle. During normal activity, oxidative muscles tend to be used frequently, for extended periods of time and at low intensities.…”

Section: The Journal Of Experimental Biologymentioning

confidence: 99%

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Getting the jump on skeletal muscle disuse atrophy: preservation of contractile performance in aestivatingCyclorana alboguttata(Günther 1867)

Symonds

James

Franklin

2007

Journal of Experimental Biology

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SUMMARY Prolonged immobilisation or unloading of skeletal muscle causes muscle disuse atrophy, which is characterised by a reduction in muscle cross-sectional area and compromised locomotory function. Animals that enter seasonal dormancy, such as hibernators and aestivators, provide an interesting model for investigating atrophy associated with disuse. Previous research on the amphibian aestivator Cyclorana alboguttata (Günther 1867)demonstrated an absence of muscle disuse atrophy after 3 months of aestivation, as measured by gastrocnemius muscle contractile properties and locomotor performance. In this study, we aimed to investigate the effect of aestivation on iliofibularis and sartorius muscle morphology and contractile function of C. alboguttata over a longer, more ecologically relevant time-frame of 9 months. We found that whole muscle mass, muscle cross-sectional area, fibre number and proportions of fibre types remained unchanged after prolonged disuse. There was a significant reduction in iliofibularis fibre cross-sectional area (declined by 36% for oxidative fibre area and 39% for glycolytic fibre area) and sartorius fibre density (declined by 44%). Prolonged aestivation had little effect on the isometric properties of the skeletal muscle of C. alboguttata. There was a significant reduction in the isometric contraction times of the relatively slow-twitch iliofibularis muscle, suggesting that the muscle was becoming slower after 9 months of aestivation (time to peak twitch increased by 25%, time from peak twitch to half relaxation increased by 34% and time from last stimulus to half tetanus relation increased by 20%). However, the results of the work-loop analysis clearly demonstrate that, despite changes to muscle morphology and isometric kinetics, the overall contractile performance and power output levels of muscles from 9-month aestivating C. alboguttata are maintained at control levels.

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Section: Muscle Morphologysupporting

confidence: 63%

Section: The Journal Of Experimental Biologymentioning

confidence: 99%

Getting the jump on skeletal muscle disuse atrophy: preservation of contractile performance in aestivatingCyclorana alboguttata(Günther 1867)

Symonds

James

Franklin

2007

Journal of Experimental Biology

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“…These authors noted, however, that there were small but significant decreases in the latencies of some of the denervation phenomena when the nerve was divided close to muscle rather than at a distance; such a result would favour interrupted axoplasmic transport as a mechanism. Other authors, using a variety of experimental procedures to cause disuse, have been able to induce shortening of the isometric twitch duration, with decreases in twitch and tetanic tensions, in soleus muscles (Vrbova, 1963;Fischbach & Robbins, 1969); changes in fast-twitch muscles have been less impressive (Mann & Salafsky, 1970;Booth & Kelso, 1973;Maier, Crockett, Simpson, Saubert & Edgerton, 1976; Corley, Kowalchuk & McComas, 1984).…”

Section: Introductionmentioning

confidence: 99%

Effects of impulse blockade on the contractile properties of rat skeletal muscle.

Kowalchuk¹,

McComas²

1987

The Journal of Physiology

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SUMMARY1. Pressure was used to produce a localized block of impulse conduction in motor nerve fibres supplying rat plantaris and soleus muscles. After 1 week of inactivity both muscles exhibited marked atrophy of type I and type II muscle fibres.2. In treated plantaris and soleus muscles the specific tetanic tensions were reduced to approximately half those of untreated control muscles; the specific twitch tensions were unchanged. The fall in specific tetanic tension in the nerve-blocked muscles was not associated with impaired excitation of muscle fibres during repetitive stimulation.3. In nerve-blocked plantaris muscles the contraction and half-relaxation times became significantly prolonged whereas no change could be demonstrated in similarly treated soleus muscles. In both muscles the maximum rates of tetanic tension development increased following nerve block.4. It is concluded that, in the rat, most of the changes in contractile properties and in muscle fibre size which follow denervation may be attributed to disuse rather than to interruption of axoplasmic transport.

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“…24,29 Discue can have a significant effect on dynamic properties of mammalian muscle. 3,8,9,14,16,21,26,37,38 The effects of immobilization have been studied in relation to morphological, 14,37 biochemical, 3 and physiological 8,37 changes in animal and human muscle. Results from chronic spinal transected cats revealed muscle atrophy, reduced Tf, a shift toward faster histochemical and contractile properties, as well as increased fatigue in respose to an unfused tetanus.…”

mentioning

confidence: 99%

Evidence of an abnormal intramuscular component of fatigue in multiple sclerosis

et al. 1995

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The goals of this study were to investigate muscle fatigue in patients with multiple sclerosis (MS), and to determine the relationships between muscle fatigue, clinical status, and perceived fatigue. The fatigability of the anterior tibial muscle was quantitated in patients and controls during 9 min of intermittent stimulation (used to eliminate central sources of muscle fatigue). During exercise, the decline in tetanic force, phosphocreatine, and intracellular pH was greater in patients than in controls. The compound muscle action potential amplitude did not decrease during exercise, indicating that there was no failure of neuromuscular transmission during fatigue. Thus, the excessive fatigue in MS developed from sources beyond the muscle memberane. Following exercise, the recovery of tetanic force was delayed in patients (a pattern that suggests abnormal excitation-contraction coupling), whereas the recovery of metabolites was complete in both groups. Muscular fatigue was correlated with clinical disability but not with perceived fatigue. These results suggests that fatigue in MS has both central (perception, upper motor neuron dysfunction) and peripheral (impaired metabolism and excitation-contraction coupling) components. Keywordsexercise; excitation-contraction coupling; metabolism; magnetic resonance spectroscopy Fatigue is a common and frequently disabling symptom in patients with multiple sclerosis (MS). 11 However, the mechanisms of fatigue in MS remain unclear. 5,28 Central sources of fatigue might well be a factor for MS patients, and could involve at least two different mechanisms. First, recruitment of alpha motor neurons is impaired because of lesions in corticospinal pathways. 33 Second, reaction times are delayed and cognitive activity is abnormal in many patients with MS, suggesting that the processes involved in preparing for and initiating motor responses are also affected. 34,35 Previous studies have shown that peripheral sources of fatigue are also important in spastic muscles. 24,29 Lenman et al. suggested secondary changes in spastic muscles are similar to those of immobilization and disuse. 24 In another study of a small number of patients with various types of spastic paraparesis, greater changes in energy metabolites accompanied the excessive muscle fatigue observed in patients compared to controls, which suggested that intramuscular factors may contribute to fatigue in spastic paraparesis. 29 Recently, in patients with MS, we have observed both reduced muscular oxidative capacity, 19 Therefore, the main objective of this study was to investigate muscle fatigue in MS patients, and to determine the extent to which muscle fatigue was related to clinical status and perceived fatigue. We examined fatigue in a group of MS patients and in healthy control subjects by measuring muscle force, activation, and energy metabolism during electrical stimulation of the anterior tibial muscle. By using stimulated contractions to induce muscle fatigue, central factors were eliminated and the per...

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Properties of immobilized guinea pig hindlimb muscles

Cited by 92 publications

References 0 publications

Getting the jump on skeletal muscle disuse atrophy: preservation of contractile performance in aestivatingCyclorana alboguttata(Günther 1867)

Getting the jump on skeletal muscle disuse atrophy: preservation of contractile performance in aestivatingCyclorana alboguttata(Günther 1867)

Effects of impulse blockade on the contractile properties of rat skeletal muscle.

Evidence of an abnormal intramuscular component of fatigue in multiple sclerosis

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