Properties of immunoglobulin A in serum of individuals with liver diseases and in hepatic bile

Kutteh, William H.; Prince, Shirley J.; Phillips, John O.; Spenney, Jerry G.; Městecký, Jiří

doi:10.1016/0016-5085(82)90003-8

Cited by 136 publications

(33 citation statements)

References 33 publications

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“…For example, almost one half of pIgA in the hepatic bile (Kutteh et al, 1982b;, and 10% of pIgA in colostrum (Mestecky et al, 1970) lack SC. The proportion of pIgA forms relative to mIgA also differs in various secretions (Table 1 and Appendix I).…”

Section: Secretory Igamentioning

confidence: 97%

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Mucosal Immunoglobulins

Woof

2015

Mucosal Immunology

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Section: Secretory Igamentioning

confidence: 97%

“…The proportion of mIgA in external secretions varies with location. In saliva, intestinal washings, tears, and milk, mIgA represents 5-10% of total IgA, whereas in urine, cervical fluid, and bile, approximately 20-60% is mIgA (Kutteh et al, 1982b(Kutteh et al, , 1993Svanborg Eden et al, 1985).…”

Section: Iga Structure and Arrangement Of Component Chainsmentioning

confidence: 97%

Mucosal Immunoglobulins

Woof

2015

Mucosal Immunology

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“…Clear evidence demonstrates that the liver alteration is induced by the toxic effects of ethanol (1). However, several abnormalities in the immune systems of alcoholic cirrhosis (AC) patients have been described (2)(3)(4)(5)(6)(7)(8)(9). The cellular and molecular bases of these immune alterations, as well as their pathogenic significance and clinical implications, remain unknown.…”

Section: -670)mentioning

confidence: 99%

Increased Spontaneous and Lymphokine–Conditioned Iga and Igg Synthesis by B Cells From Alcoholic Cirrhotic Patients

et al. 1992

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Immunoglobulin secretion by B lymphocytes is a complex process in which lymphokines secreted by T lymphocytes play an important regulatory role. Increased serum levels of IgA and IgG have been characteristically detected in patients with alcoholic cirrhosis. We have studied the functional alterations of T and B lymphocytes implicated in the physiopathology of this common immunoglobulin abnormality. After activation with phytohemagglutinin, purified T cells from alcoholic cirrhotic patients showed significantly enhanced secretion of B-cell differentiation factors for IgG and IgA with respect to those secreted by T cells from healthy controls (p less than 0.05). Simultaneously, normal secretion of B-cell differentiation factor for IgM was demonstrated in T lymphocytes from these patients. The pattern of secretion of the lymphokines involved in the regulation of the B-cell differentiation pathway found in alcoholic cirrhotic patients was different from that of the primary biliary cirrhotic patients studied. Purified B cells from patients with alcoholic cirrhosis secreted significantly higher amounts of IgA and IgG than did those found in healthy controls, both spontaneously (p less than 0.05) and after sequential activation with immunoglobulin ligands (Staphylococcus aureus Cowan I) and a standard B-cell differentiation factor preparation (p less than 0.05). By contrast, the IgM secretion and regulatory pathway were normal in alcoholic cirrhotic patients. These results support a physiopathological explanation for the characteristic hyperimmunoglobulinemia found in patients with alcoholic cirrhosis.

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“…The immunologically active immunoglobulin is polymeric IgA (pIgA), which consists of aggregates of the 160 kdalton monomer joined by a 15‐kdalton peptide called “J” piece. Plasma cells associated with the mucosal surfaces, eg, in the lamina propria of the small intestine, are largely responsible for the synthesis of pIgA, whereas bone marrow cells produce approximately 10% pIgA and the remainder in monomelic form 27 . Therefore, most of the serum IgA in nonimmune individuals is in the monomeric form.…”

Section: Structure and Function Of The Gastrointestinal Secretory Immmentioning

confidence: 99%

Aging, Gastrointestinal Infections, and Mucosal Immunity

Schmucker¹,

Daniels²

1986

J American Geriatrics Society

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The elderly constitute the fastest growing segment of the population and, as such, pose significant and unique health care problems. Aging is characterized by a decline in the organism's ability to respond or to adapt to a variety of environmental stresses. An example of this reduced “adaptive responsiveness” can be found in the immune system which undergoes a marked and well‐documented decline during aging.1 Perhaps as a result of this deficiency, the incidence of infectious diseases and the associated morbidity and mortality increase significantly in the elderly.2–4 Furthermore, the greater frequency of chronic diseases in the elderly predisposes them to complications resulting from infections.

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Properties of immunoglobulin A in serum of individuals with liver diseases and in hepatic bile

Cited by 136 publications

References 33 publications

Mucosal Immunoglobulins

Mucosal Immunoglobulins

Increased Spontaneous and Lymphokine–Conditioned Iga and Igg Synthesis by B Cells From Alcoholic Cirrhotic Patients

Aging, Gastrointestinal Infections, and Mucosal Immunity

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