Properties of Meshes used in Hernia Repair: A Comprehensive Review of Synthetic and Biologic Meshes

Ibrahim, Ahmed M.S.; Vargas, Christina R.; Colakoğlu, Salih; Nguyen, John; Lin, Samuel J.; Lee, Bernard T.

doi:10.1055/s-0034-1376886

Cited by 33 publications

(21 citation statements)

References 48 publications

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“…28 Bleichrodt et al repaired contaminated abdominal wall defects in rats with using PP mesh and PTFE mesh, and at the end of the follow-up period, they found that 76.2% of the PTFE mesh group and 66.7% of the PP mesh group had SSI, and there was no statistically significant difference between the two groups in terms of the SSI rate. 15 In the current study, no adhesion was seen in any of the rats in the PTFE and ePTFE groups and all were found to develop SSI; therefore, the SSI rates of these two groups differed from that of the PP mesh group. Furthermore, the SSI rates were high in all study groups due to the mesh being applied to a contaminated wound.…”

Section: Discussioncontrasting

confidence: 42%

“…1,[5][6][7][8][9][10][11][12][13] Researchers have yet to reach a consensus regarding the type of material to be used. [14][15][16] A Bogota bag is often preferred because it is far more inexpensive and available compared to the other materials; however, PTFE or PP mesh is often used to close the abdominal wall defect after the removal of the Bogota bag.…”

Section: Introductionmentioning

confidence: 99%

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Which mesh should be used to repair abdominal wall defect in peritonitis? An experimental study

Alakuş

Göksu

2020

Int Surg J

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Background: In this study, following the Bogota bag closure of abdominal wall defects created in a rat peritonitis model, the short-term efficacy of polypropylene (PP) mesh (Prolene®, Ethicon), PP Mesh+Seprafilm®, polytetrafluoroethylene (PTFE) mesh [Infinit® Mesh (Gore)] and expanded PTFE (ePTFE) [Dualmesh®plus(Gore)] in the permanent repair of the defects was investigated.Methods: 64 rats were used. The rats were randomized into four groups, each consisting of 16 subjects: PP mesh (Group 1), PP mesh+Seprafilm (Group 2), PTFE mesh (Group 3), and ePTFE mesh (Group 4). Laparotomy was performed and abdominal wall defects were created. Contamination of the peritoneal cavity was induced, and closure was undertaken using a Bogota bag. After three days, the Bogota bag was removed, and materials were placed. At the end of the follow-up period, the rats were sacrificed. Mortality, grade of adhesion, surgical site infection (SSI), and tensile strength were evaluated.Results: Mortality was calculated as 6.3%, 50%, 25%, and 0% for Groups 1, 2, 3, and 4, respectively (p=0.002). Adhesion was observed at a rate of 61.1% in Group 1 and 38.9% in Group 2 (p=0.621). There was no adhesion in Groups 3 and 4 (p=0.001). The rate of SSI was 68.8% in Group 1, %75% in Group 2, and 100% in Groups 3 and 4 (p=0.022). Tensile strength was 2196±193.6 g/cm in Group 1 and 1906±142.1 g/cm in Group 2 (p=0.258).Conclusions: We argue that PP mesh is a suitable prosthesis for the permanent repair of contaminated abdominal wall defects despite the increased adhesion risk.

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Section: Discussioncontrasting

confidence: 42%

Section: Introductionmentioning

confidence: 99%

Which mesh should be used to repair abdominal wall defect in peritonitis? An experimental study

Alakuş

Göksu

2020

Int Surg J

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“…This antiadhesion effect of PCO mesh could be ascribed to the smooth surface of collagen coating, which did not provide any physical anchor points for adhesive tissue . However, several studies have reported that PCO mesh may have some complications such as seroma and infections, while lightweight PP mesh can resist to such complication because of its large pore structure . The PDA coating did not alter the large pore structure of lightweight PP mesh and preserved its good properties including high permeability and biocompatibility.…”

Section: Discussionmentioning

confidence: 98%

“…The cost of PP/PDA is estimated to be US dollar (USD) 3 cm −2 , which proves economically competitive with the advanced meshes used for ventral hernia repair today, including PCO (USD 20 cm −2 ) and biological meshes (more than USD 60 cm −2 ). Further investigation indicated that PCO mesh, one of the synthetic meshes, had more complications of infection and recurrence than other meshes . Moreover, it was demonstrated that expanded polytetrafluoroethylene (ePTFE) hernia mesh still induced infection, seroma, and shrinkage due to its masked and blocked pores and inflammatory response of the body to foreign materials .…”

Section: Discussionmentioning

confidence: 99%

“…Further investigation indicated that PCO mesh, one of the synthetic meshes, had more complications of infection and recurrence than other meshes . Moreover, it was demonstrated that expanded polytetrafluoroethylene (ePTFE) hernia mesh still induced infection, seroma, and shrinkage due to its masked and blocked pores and inflammatory response of the body to foreign materials . If mesh with disappeared pores become nonpermeable, the inflammatory cell cannot go through the mesh freely and may be weak to endure infection .…”

Section: Discussionmentioning

confidence: 99%

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Lightweight, Highly Permeable, Biocompatible, and Antiadhesive Composite Meshes for Intraperitoneal Repairs

Lin

Huang

et al. 2018

Macromolecular Bioscience

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Ventral hernia is a public health issue and millions of meshes are used to repair abdominal wall defects every year. Polypropylene-based composite meshes represent an important class of materials for intraperitoneal repair, but the meshes generally give rise to infection, seroma, migration, and adhesion, leading to severe consequence or even reoperation. Here, a facile and versatile one-way fabrication of lightweight, highly permeable, and biocompatible composite meshes with superior antiadhesion properties is proposed by modifying polypropylene meshes with well-defined polydopamine nanocoating. The resulting composite meshes are found to significantly enhance the biocompatibility and antiadhesion effect in rat model. The scalable production and excellent biomedical properties of composite meshes make them a promising candidate for future-generation ventral hernia repair materials.

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Transient Implantable Electronics for Postsurgery Preventive Medicine

Mirzajani,

Zolfaghari,

Akbari Nakhjavani

et al. 2024

Adv Funct Materials

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The field of postoperative care has seen a remarkable shift toward the utilization of electronic implantable devices, including sensors, biosensors, stimulators, and drug delivery systems, all designed with a biodegradable form factor and wireless data/power transmission capability. These technologies hold immense potential for postsurgery out‐of‐hospital monitoring during the postdischarged period, where continuous monitoring of physiological signals is lacking. Furthermore, these devices eliminate the need for secondary surgeries required for device retrieval as they can safely degraded in the body, thus enhancing patient recovery. This review delves into the latest advancements in biodegradable implantable devices, examining their application in monitoring vital signs, the innovative wireless communication and powering technologies they employ, and the biodegradable materials that enable their function. The analysis extends to evaluating the efficacy and limitations of these devices across various medical applications. Moreover, it explores future research directions, emphasizing material advancements, device miniaturization, customization, and the integration of artificial intelligence to create closed‐loop therapeutic systems. This comprehensive review underscores the transformative potential of these technologies in enhancing postoperative care and outlines the pathway for future innovations in this dynamic field.

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Properties of Meshes used in Hernia Repair: A Comprehensive Review of Synthetic and Biologic Meshes

Cited by 33 publications

References 48 publications

Which mesh should be used to repair abdominal wall defect in peritonitis? An experimental study

Which mesh should be used to repair abdominal wall defect in peritonitis? An experimental study

Lightweight, Highly Permeable, Biocompatible, and Antiadhesive Composite Meshes for Intraperitoneal Repairs

Transient Implantable Electronics for Postsurgery Preventive Medicine

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