Properties of nanofiller-loaded poly (methyl methacrylate) bone cement composites for orthopedic applications: a review

Lewis, Gladius

doi:10.1002/jbm.b.33643

Cited by 47 publications

(29 citation statements)

References 92 publications

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“…On the one hand, they demonstrated that the addition of the nanoparticles did not alter the mechanical properties of the cement and provided antibacterial effects against S. aureus and S. epidermidis [93]. The best antibacterial results were achieved with the quaternary ammonium chitosan nanoparticles, which was in agreement with other authors probably due to its higher surface density when compared to chitosan, as explained in [94].…”

Section: Polymethyl Methacrylate-based Cementssupporting

confidence: 86%

Antibacterial Bio-Based Polymers for Cranio-Maxillofacial Regeneration Applications

Martín-del-Campo¹,

Fernadez-Villa²,

Cabrera-Rueda³

et al. 2020

Preprint

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Cranio-maxillofacial structure is a region of particular interest in the field of regenerative medicine due to both its anatomical complexity and the numerous abnormalities affecting this area. However, this anatomical complexity is what makes possible the coexistence of different microbial ecosystems in the oral cavity and the maxillofacial region, contributing to the increased risk of bacterial infections. In this regard, different materials have been used for their application in this field. These materials can be obtained from natural and renewable feedstocks or by synthetic routes with desired mechanical properties, biocompatibility and antimicrobial activity. Hence, in this review, we have focused on bio-based polymers, which by their own nature, by chemical modifications of their structure, or by their combination with other elements, provide a useful antibacterial activity as well as the suitable conditions for cranio-maxillofacial tissue regeneration. This approach has not been reviewed previously, and we have specifically arranged the content of this article according to the resulting material and its corresponding application, reviewing guided bone regeneration membranes; bone cements; and devices and scaffolds for both soft and hard maxillofacial tissue regeneration, including hybrid scaffolds, dental implants, hydrogels and composites.

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Section: Polymethyl Methacrylate-based Cementssupporting

confidence: 86%

Antibacterial Bio-Based Polymers for Cranio-Maxillofacial Regeneration Applications

Martín-del-Campo¹,

Fernadez-Villa²,

Cabrera-Rueda³

et al. 2020

Preprint

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“…Injectable bone cements are crucial to the outcome of fractured vertebral body augmentation procedures, such as vertebroplasty (VP) and balloon kyphoplasty (KP). 1,2 PVP was introduced in 1987, by Galibert and Deramond 3 for the treatment of painful vertebral hemangiomas. PVP is a therapeutic interventional radiological procedure for pain relief and strengthening of the bone, involving the injection of a bone cement dough into a cervical, thoracic, or lumbar vertebral body lesion.…”

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of injectable PMMA‐strontium‐substituted bioactive glass bone cement composites

et al. 2017

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In most minimally-invasive procedures used to address severe pain arising from compression fractures of the vertebral bodies, such as percutaneous vertebroplasty (PVP), a poly(methyl methacrylate) (PMMA) bone cement is used. Shortcomings of this type of cement, such as high exotherm temperature and lack of bioactivity, are well known. We prepared different formulations of a composite bone cement, whose solid constituents consisted of PMMA beads and particles of a bioactive glass (BG), where 0-20%(w/w) of the calcium component was substituted by strontium. The difference between the formulations was in the relative amounts of the solid phase constituents and in the Sr-content of BG. We determined the influence of the mixture of solid phase constituents of the cement formulation on a collection of properties, such as maximum exotherm temperature (T ), setting time (t ), and injectability (I). The selection of the PMMA beads was crucial to obtain cement composite formulations capable to be efficiently injected. Results allowed to select nine solid phase mixtures to be further tested. Then, we determined the influence of the composition of these composite bone cements on T , t , I, and cell proliferation. The results showed that the performance of various of the selected composite cements was better than that of PMMA cement reference, with lower T , lower t , and higher I. We found that incorporation of Sr-substituted BGs into these materials bestows bioactivity properties associated with the role of Sr in bone formation, leading to some composite cement formulations that may be suitable for use in PVP. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1245-1257, 2018.

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“…This suggests that our method can provide enhanced contrast without loss of the enhanced material strength. Wei et al24 also showed that gentamicin-doped HNTs added to PMMA could provide sustained gentamicin release without loss of material properties 17. In fact, gains in tensile strength and adhesion were observed.…”

Section: Discussionmentioning

confidence: 98%

Effect of barium-coated halloysite nanotube addition on the cytocompatibility, mechanical and contrast properties of poly(methyl methacrylate) cement

Jammalamadaka¹,

Tappa²,

Weisman³

et al. 2017

NSA

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Halloysite nanotubes (HNTs) were investigated as a platform for tunable nanoparticle composition and enhanced opacity in poly(methyl methacrylate) (PMMA) bone cement. Halloysite has been widely used to increase the mechanical properties of various polymer matrices, in stark contrast to other fillers such as barium sulfate that provide opacity but also decrease mechanical strength. The present work describes a dry deposition method for successively fabricating barium sulfate nanoparticles onto the exterior surface of HNTs. A sintering process was used to coat the HNTs in barium sulfate. Barium sulfate-coated HNTs were then added to PMMA bone cement and the samples were tested for mechanical strength and tailored opacity correlated with the fabrication ratio and the amount of barium sulfate-coated HNTs added. The potential cytotoxic effect of barium-coated HNTs in PMMA cement was also tested on osteosarcoma cells. Barium-coated HNTs were found to be completely cytocompatible, and cell proliferation was not inhibited after exposure to the barium-coated HNTs embedded in PMMA cement. We demonstrate a simple method for the creation of barium-coated nanoparticles that imparted improved contrast and material properties to native PMMA. An easy and efficient method for coating clay nanotubes offers the potential for enhanced imaging by radiologists or orthopedic surgeons.

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Properties of nanofiller-loaded poly (methyl methacrylate) bone cement composites for orthopedic applications: a review

Cited by 47 publications

References 92 publications

Antibacterial Bio-Based Polymers for Cranio-Maxillofacial Regeneration Applications

Antibacterial Bio-Based Polymers for Cranio-Maxillofacial Regeneration Applications

Preparation and characterization of injectable PMMA‐strontium‐substituted bioactive glass bone cement composites

Effect of barium-coated halloysite nanotube addition on the cytocompatibility, mechanical and contrast properties of poly(methyl methacrylate) cement

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