Properties of Solid Dispersions of Naproxen in Various Polyethylene Glycols

Mura, Paola; Manderioli, A.; Bramanti, G; Ceccarelli, L.

doi:10.3109/03639049609065920

Cited by 87 publications

(59 citation statements)

References 11 publications

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“…Trapani et al (16) reported that PEG 6000 shows a lower solubilization capacity than PEG 4000 (102 and 92 mg/mL for PEG 6000 and PEG 4000, respectively). These results agree with the well-established formation of soluble complexes between the watersoluble polymeric carriers and poorly water-soluble drugs (17). At an 18% (w/v) concentration of PEG 4000, the solubility of gliclazide increased by a factor of 3.4 (Table 1).…”

Section: Results and Discussion Solubility Studiessupporting

confidence: 80%

An Approach for Improvement of the Dissolution Rate of Gliclazide

Biswal¹,

Pasa²,

Sahoo³

et al. 2009

Dissolution Technol.

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Gliclazide is an anti-diabetic drug that is poorly soluble in water. This paper describes an approach to improve the dissolution rate of gliclazide by using solid dispersions (SDs) in polyethylene glycol 4000 (PEG 4000). The phase-solubility behavior of gliclazide in the presence of various concentrations of PEG 4000 in 0.1 N HCl at 37 °C was obtained. The solubility of gliclazide increased with increasing amounts of PEG 4000 in water. The Gibbs free energy (∆G o tr ) values were all negative. The solid dispersions were prepared with a solvent-melting method using different concentrations of PEG 4000. X-ray diffraction, infrared spectroscopy, and DSC were used to examine the physicochemical characteristics of solid dispersions of gliclazide and PEG. The dissolution rate of gliclazide in SDs with PEG 4000 was enhanced. The FTIR spectroscopic studies showed the presence of intermolecular hydrogen bonding between gliclazide and PEG 4000 in the solid state. The DSC and XRD studies indicate the amorphous and microcrystalline states of gliclazide in SDs with PEG 4000.

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Section: Results and Discussion Solubility Studiessupporting

confidence: 80%

An Approach for Improvement of the Dissolution Rate of Gliclazide

Biswal¹,

Pasa²,

Sahoo³

et al. 2009

Dissolution Technol.

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show abstract

“…But there is significant difference present in solubility of drug and SDs prepared both by kneading method and solvent evaporation method (1:5). These results are in accordance with the established formation of soluble complex between water-soluble polymeric carriers and poorly soluble drug (Mura et al, 1996, Zerrouk et al, 2002. …”

Section: Saturation Solubility Of Flb Solid Dispersionssupporting

confidence: 77%

Development, Characterization and In Vitro Evaluation of Flurbiprofen Solid Dispersions using Polyethylene Glycols as Carrier

Yadav¹,

Tanwar²

2016

J App Pharm Sci

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The purpose of the present investigation was to increase the solubility and dissolution rate of flurbiprofen (FLB) by the preparation of its solid dispersion with polyethylene glycol 4000 and 6000 as carriers using solvent evaporation method (SM) and kneading method (KM). Drug polymer interactions were investigated using Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), x-ray diffraction (XRD). The prepared solid dispersions were characterized by IR spectroscopy, which suggests no interaction of drug with carriers. XRD and DSC study indicates reduction in drug cr ystallinity. Drug solubility was more and also the dissolution was rapid for Flurbiprofen solid dispersions compared to pure drug.

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“…Enhanced solubility and dissolution of ibuprofen from physical mixtures could be related to the surface activity, wetting effect which may lead to reduced agglomeration and hence increased surface area, and solubilizing effect of PEG 8000. [7][8][9][13][14][15][16][17][18][19] In the dry state, drug particles were in close contact or adhered to the polymer particles as a result of mixing (shown by SEM). When the mixture came in contact with water, the polymer particles might have hydrated rapidly (because of the high hydrophilic potency of PEG 8000) into polymer solution contributing to the increased wettability of the drug particles and to the local enhancement of the drug solubility at the diffusion layer surrounding the particles and subsequently releasing the drug into the medium.…”

Section: Resultsmentioning

confidence: 99%

Enhancement of Solubility, Dissolution and Bioavailability of Ibuprofen in Solid Dispersion Systems

et al. 2008

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To improve its solubility, dissolution, and bioavailability; Ibuprofen-polyethylene glycol 8000 (PEG 8000) solid dispersions (SDs) with different drug loadings were prepared, characterized by scanning electron microscopy (SEM) and differential scanning calorimetry (DSC), and evaluated for solubility, in-vitro release, and oral bioavailability of ibuprofen in rats. Loss of individual surface properties during melting and solidification as revealed by SEM micrographs indicated the formation of effective SDs. Absence or shifting towards the lower melting temperature of the drug peak in SDs and physical mixtures in DSC study indicated the possibilities of drug-polymer interactions. Quicker release of ibuprofen from SDs in rat intestine resulted in a significant increase in AUC and C max , and a significant decrease in T max over pure ibuprofen. Preliminary results of this study suggested that the preparation of ibuprofen SDs using PEG 8000 as a meltable hydrophilic polymer carrier could be a promising approach to improve solubility, dissolution and bioavailability of ibuprofen.

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Properties of Solid Dispersions of Naproxen in Various Polyethylene Glycols

Cited by 87 publications

References 11 publications

An Approach for Improvement of the Dissolution Rate of Gliclazide

An Approach for Improvement of the Dissolution Rate of Gliclazide

Development, Characterization and In Vitro Evaluation of Flurbiprofen Solid Dispersions using Polyethylene Glycols as Carrier

Enhancement of Solubility, Dissolution and Bioavailability of Ibuprofen in Solid Dispersion Systems

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