2022
DOI: 10.1007/s00429-022-02458-1
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Properties of the epileptiform activity in the cingulate cortex of a mouse model of LIS1 dysfunction

Abstract: Dysfunction of the LIS1 gene causes lissencephaly, a drastic neurological disorder characterized by a deep disruption of the cortical structure. We aim to uncover alterations of the cortical neuronal networks related with the propagation of epileptiform activity in the Lis1/sLis1 mouse, a model lacking the LisH domain in heterozygosis. We did extracellular field-potential and intracellular recordings in brain slices of the anterior cingulate cortex (ACC) or the retrosplenial cortex (RSC) to study epileptiform … Show more

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Cited by 2 publications
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“…The propagation of neural activity in layers II/III and intrahemispheric connections under gamma-aminobutyric acid (GABA)ergic blockade has been extensively studied using electrophysiological methods (Walker et al, 2012;Rovira and Geijo-Barrientos, 2016;Robles et al, 2020;Domínguez-Sala et al, 2022). However, the present study did not detect any oscillatory activity under these conditions, possibly owing to the weak blockade of GABAergic systems.…”
Section: Population Propagation Of Neural Activity Under Weak Gabaerg...contrasting
confidence: 66%
“…The propagation of neural activity in layers II/III and intrahemispheric connections under gamma-aminobutyric acid (GABA)ergic blockade has been extensively studied using electrophysiological methods (Walker et al, 2012;Rovira and Geijo-Barrientos, 2016;Robles et al, 2020;Domínguez-Sala et al, 2022). However, the present study did not detect any oscillatory activity under these conditions, possibly owing to the weak blockade of GABAergic systems.…”
Section: Population Propagation Of Neural Activity Under Weak Gabaerg...contrasting
confidence: 66%