Properties of the ‘slow’ skeletal muscle fibres of the frog*

Kuffler, Stephen W.; Williams, E. M. Vaughan

doi:10.1113/jphysiol.1953.sp004949

Cited by 299 publications

(97 citation statements)

References 19 publications

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“…Personal communication of an experiment performed in this laboratory.) showed only phasic tension when placed in physiological saline with up to 100 mM of its Na + replaced with K + , thus indicating that only twitch fibers were present (Kuffler and Vaughan Williams, 1953).…”

Section: Artifact Controlsmentioning

confidence: 99%

Initial Heat Production in Isometric Frog Muscle at 15°C

Fraser

Carlson

1973

The Journal of General Physiology

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An infrared radiation-detecting system was used to measure initial heat production in bull frog sartorius muscle at 15 0 C. Numerous tests with the system showed that thermal artifacts were not noticeable. Many previous measurements with myothermic thermopiles were corroborated with this method. In addition, a cooling phase as large as 0.39 of peak exothermicity was found during and after relaxation. Cooling diminished with both increasing sarcomere length and increasing duration of mechanical activity. No large rapid increase in heat rate accompanied a 0.6 reactivation at the peak of twitch tension. Above rest length, initial heat rate and the heat produced up to the peak of tension decreased nearly proportionally with overlap of myofilaments, while the total twitch initial heat decreased slightly.

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Section: Artifact Controlsmentioning

confidence: 99%

Initial Heat Production in Isometric Frog Muscle at 15°C

Fraser

Carlson

1973

The Journal of General Physiology

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“…Both these types of striated muscle fibres have been demonstrated in the extraocular muscles of the cat (Hess & Pilar, 1963). It is well known that mammalian extraocular muscles can respond by a contracture to acetylcholine (Duke-Elder & Duke-Elder, 1930;Brown & Harvey, 1941;Hess & Pilar, 1963), a characteristic previously described for slow muscle fibres in the frog (Kuffler & Vaughan Williams, 1953b). Recently, it had been suggested (Eakins & Katz, 1965) that succinylcholine has two actions on the extraocular muscles of the cat, a depression of the fast or twitch system and a simultaneous stimulation of the slow muscle system, resulting in a sustained contracture similar to that observed after acetylcholine.…”

Section: Discussionmentioning

confidence: 88%

The Action of Succinylcholine on the Tension of Extraocular Muscle

Eakins¹,

Katz²

1966

British Journal of Pharmacology and Chemotherapy

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“…The frog rectus abdominis muscle is believed to contain slow muscle fibres which respond to acetylcholine (and other depolarizing substances) with slow contractile changes (Brecht and Epple, 1952;Kuffler and Vaughan Williams, 1953). Such slow muscle fibre systems in frog ilio-fibularis muscle show true mechanical facilitation-that is, during a series of stimuli successive nerve volleys add increasing amounts of tension (Kuffler and Vaughan Williams, 1953 (Table II) over and above the increased sensitization to acetylcholine induced indirectly by inactivation of cholinesterase (Miquel, 1946).…”

Section: Discussionmentioning

confidence: 99%

“…Such slow muscle fibre systems in frog ilio-fibularis muscle show true mechanical facilitation-that is, during a series of stimuli successive nerve volleys add increasing amounts of tension (Kuffler and Vaughan Williams, 1953 (Table II) over and above the increased sensitization to acetylcholine induced indirectly by inactivation of cholinesterase (Miquel, 1946). (Table III) may be attributed to accumulation of endogenous acetylcholine in the presence of an anticholinesterase (Fatt and Katz, 1952).…”

Section: Discussionmentioning

confidence: 99%

Reciprocal Potentiating Action of Depolarizing Drugs on the Isolated Frog Rectus Abdominis Muscle

Fleisher

Corrigan

Howard

1960

British Journal of Pharmacology and Chemotherapy

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Subthreshold concentrations of the depolarizing agents, acetylcholine and decamethonium, potentiated isotonic contractures of the isolated frog rectus abdominis muscle elicited by effective doses of either of these drugs or by choline in the absence of the anticholinesterases, sarin, or dyflos. Comparable potentiation of the contracture produced by decamethonium or choline could be obtained by alternate stimulation with acetylcholine in the absence of dyflos or sarin. Furthermore, dyflos alone did not effect potentiation in the absence of alternate stimulation with acetylcholine. Finally, the inhibitory action of tubocurarine, as measured by depression of the contracture elicited by decamethonium and acetylcholine, was not antagonized by sarin. It was concluded that the enhancement of the response to acetylcholine produced by dyflos and by sarin was brought about exclusively by their action as inhibitors of cholinesterase. The ability of dyflos .and of sarin to potentiate conttactures elicited by decamethonium or by choline may be attributed to a facilitation of the action of the depolarizing compounds by subthreshold concentrations of acetylcholine available in the presence of these anticholinesterases. Cohen and Posthumus (1955) observed that dyflos (di-isopropyl phosphorofluoridate) and sarin (isopropyl methylphosphonofluoridate) potentiate the effects of decamethonium and choline on the isolated frog rectus abdominis muscle. Because decamethonium and choline are not esters, and are therefore not hydrolysed by cholinesterase, they concluded that dyflos, and other anticholinesterases, promote a " sensitization " of acetylcholine receptors independent of any inhibition of cholinesterase activity. They further inferred that direct, non-enzymatic sensitization "is at least partly responsible for the enhanced response of the muscle toward acetylcholine after the administration of anticholinesterases." In view of the fundamental nature of their conclusions concerning the mechanism of action of anticholinesterases, a similar study on the frog rectus has been conducted in our laboratory.

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Properties of the ‘slow’ skeletal muscle fibres of the frog*

Cited by 299 publications

References 19 publications

Initial Heat Production in Isometric Frog Muscle at 15°C

Initial Heat Production in Isometric Frog Muscle at 15°C

The Action of Succinylcholine on the Tension of Extraocular Muscle

Reciprocal Potentiating Action of Depolarizing Drugs on the Isolated Frog Rectus Abdominis Muscle

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