Propesticides and their use as agrochemicals

Jeschke, Peter

doi:10.1002/ps.4170

Cited by 149 publications

(141 citation statements)

References 82 publications

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“…The vectorization of an agrochemical compound consists of modulating and controlling the distribution of an active ingredient within the plant by associating it with a vector. In the case of molecular vectorization, which is discussed in this review, the vector group will be introduced into a biologically active compound and the resulting molecule will be a propesticide . Once the molecule reaches the target, it will release the parent molecule by the action of various enzymes or by a chemical hydrolysis.…”

Section: Introductionmentioning

confidence: 99%

Vectorizing agrochemicals: enhancing bioavailability via carrier‐mediated transport

Marivingt-Mounir

et al. 2019

Pest Management Science

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Systemicity of agrochemicals is an advantageous property for controlling phloem sucking insects, as well as pathogens and pests not accessible to contact products. After the penetration of the cuticle, the plasma membrane constitutes the main barrier to the entry of an agrochemical into the sap flow. The current strategy for developing systemic agrochemicals is to optimize the physicochemical properties of the molecules so that they can cross the plasma membrane by simple diffusion or ion trapping mechanisms. The main problem with current systemic compounds is that they move everywhere within the plant, and this non‐controlled mobility results in the contamination of the plant parts consumed by vertebrates and pollinators. To achieve the site‐targeted distribution of agrochemicals, a carrier‐mediated propesticide strategy is proposed in this review. After conjugating a non‐systemic agrochemical with a nutrient (α‐amino acids or sugars), the resulting conjugate may be actively transported across the plasma membrane by nutrient‐specific carriers. By applying this strategy, non‐systemic active ingredients are expected to be delivered into the target organs of young plants, thus avoiding or minimizing subsequent undesirable redistribution. The development of this innovative strategy presents many challenges, but opens up a wide range of exciting possibilities. © 2018 Society of Chemical Industry

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Section: Introductionmentioning

confidence: 99%

Vectorizing agrochemicals: enhancing bioavailability via carrier‐mediated transport

Marivingt-Mounir

et al. 2019

Pest Management Science

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“…Upon entering the leaf, the carbonic ester group of spirotetramat (log P = 2.5; p K a = 10.7) is hydrolyzed in the plant to form the insecticidally active enol metabolite. This metabolite (log P = 0.3; p K a = 5.2) is one of the very few phloem mobile insecticides used against sap‐feeding pests …”

Section: Analysis and Discussionmentioning

confidence: 99%

Physicochemical property guidelines for modern agrochemicals

Yu¹,

Lorsbach²,

Castetter³

et al. 2018

Pest Management Science

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The relentless need for the discovery and development of new agrochemicals continues as a result of driving forces such as loss of existing products through the development of resistance, the necessity for products with more favorable environmental and toxicological profiles, shifting pest spectra, and the changing agricultural needs and practices of the farming community. These new challenges underscore the demand for novel, high-quality starting points to accelerate the discovery of new agrochemicals that address market challenges. This article discusses the efforts to identify the optimum ranges of physicochemical properties of agrochemicals through analysis of modern commercial products. Specifically, we reviewed literature studies examining physicochemical property effects and analyzed the properties typical of successful fungicides, herbicides, and insecticides (chewing and sap-feeding pests). From the analysis, a new set of physicochemical property guidelines for each discipline, as well as building block class, are proposed. These new guidelines should significantly aid in the discovery of next-generation agrochemicals. © 2018 Society of Chemical Industry.

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“…The apparent preference for interaction at the high affinity site is comparable to that of SFX and it has been suggested that cis-neonicotinoids are useful compounds to discriminate between the two IMI binding sites. 132) However these compounds are the Michael adducts of crotonaldehydes with nitromethyleneimidazole (NMI), [133][134][135] a compound known since the early 1990's 66,136,137) and the authors have not ruled out the possible release of NMI in the aqueous experimental conditions. Indeed, unlike IMI, saturation studies using [ 3 H]-NMI detected only the presence of a single binding site.…”

Section: Sulfoximinesmentioning

confidence: 99%

The invertebrate pharmacology of insecticides acting at nicotinic acetylcholine receptors

Crossthwaite

Bigot

Camblin

et al. 2017

Journal of Pesticide Science

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The nicotinic acetylcholine receptor (nAChR) is a ligand-gated ion channel composed of 5 protein subunits arranged around a central cation selective pore. Several classes of natural and synthetic insecticides mediate their effect through interacting at nAChRs. This review examines the basic pharmacology of the neonicotinoids and related chemistry, with an emphasis on sapfeeding insects from the order Hemiptera, the principle pest target for such insecticides. Although the receptor subunit stoichiometry for endogenous invertebrate nAChRs is unknown, there is clear evidence for the existence of distinct neonicotinoid binding sites in native insect preparations, which reflects the predicted wide repertoire of nAChRs and differing pharmacology within this insecticide class. The spinosyns are principally used to control chewing pests such as Lepidoptera, whilst nereistoxin analogues are used on pests of rice and vegetables through contact and systemic action, the pharmacology of both these insecticides is unique and different to that of the neonicotinoids.

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Propesticides and their use as agrochemicals

Cited by 149 publications

References 82 publications

Vectorizing agrochemicals: enhancing bioavailability via carrier‐mediated transport

Vectorizing agrochemicals: enhancing bioavailability via carrier‐mediated transport

Physicochemical property guidelines for modern agrochemicals

The invertebrate pharmacology of insecticides acting at nicotinic acetylcholine receptors

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