2023
DOI: 10.3390/ijms24021586
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Prophage-Derived Regions in Curtobacterium Genomes: Good Things, Small Packages

Abstract: Curtobacterium is a genus of Gram-positive bacteria within the order Actinomycetales. Some Curtobacterium species (C. flaccumfaciens, C. plantarum) are harmful pathogens of agricultural crops such as soybean, dry beans, peas, sugar beet and beetroot, which occur throughout the world. Bacteriophages (bacterial viruses) are considered to be potential curative agents to control the spread of harmful bacteria. Temperate bacteriophages integrate their genomes into bacterial chromosomes (prophages), sometimes substa… Show more

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“…The analysis of the structural features of phage RBPs and lysins can use modern deep-learning techniques, including AlphaFold. Together with experimental studies, AlphaFold predictions can be used to elucidate the domain organisation of TFP, TSP and cell-wall degrading enzymes, to reveal the sites of phage particle binding and enzymatic domains ( Figure 4 ) [ 45 , 46 , 47 , 52 ].…”
Section: Application Of Alphafold For Research On Bacteriophagesmentioning
confidence: 99%
“…The analysis of the structural features of phage RBPs and lysins can use modern deep-learning techniques, including AlphaFold. Together with experimental studies, AlphaFold predictions can be used to elucidate the domain organisation of TFP, TSP and cell-wall degrading enzymes, to reveal the sites of phage particle binding and enzymatic domains ( Figure 4 ) [ 45 , 46 , 47 , 52 ].…”
Section: Application Of Alphafold For Research On Bacteriophagesmentioning
confidence: 99%
“…However, some information about phage–host interactions can be recovered using the analysis of genomic CRISPR arrays [ 30 , 31 , 32 ]. Moreover, temperate phages that insert their genome into the host chromosome can leave traces of phage infection [ 33 , 34 , 35 , 36 ].…”
Section: Introductionmentioning
confidence: 99%