Prophage-encoded methyltransferase drives adaptation of community-acquired methicillin-resistantStaphylococcus aureus
Robert J. Ulrich,
Magdalena Podkowik,
Rebecca Tierce
et al.
Abstract:We recently described the evolution of a community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) USA300 variant responsible for an outbreak of skin and soft tissue infections. Acquisition of a mosaic version of the Φ11 prophage (mΦ11) that increases skin abscess size was an early step in CA-MRSA adaptation that primed the successful spread of the clone. The present report shows how prophage mΦ11 exerts its effect on virulence for skin infection without encoding a known toxin or fitness genes. … Show more
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