Prophylactic Administration of Curcumin Abates the Incidence of Hypobaric Hypoxia Induced Pulmonary Edema in Rats: A Molecular Approach

Sagi, Sarada S.K.

doi:10.4172/2161-105x.1000164

Cited by 6 publications

(5 citation statements)

References 61 publications

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“…Recently, evidence shows that prophylactic application of curcumin decreased the inflammation resulting in a reduced influx of fluid in lungs of rats under hypoxia. This was through downregulation of the pro‐inflammatory cytokines and cell adhesion molecules by modulation of NF‐кB activity and stabilizing hypoxia‐inducible factor 1‐alpha (HIF1‐α), leading to downregulation of angiogenic molecules such as VEGF followed by a reduction in pulmonary oedema and albumin extravasation in the bronchoalveolar lavage fluid of rats (T. Mathew & Sarada, 2015; Sagi, Mathew, & Patir, 2014; Titto, Ankit, Saumya, Gausal, & Sarada, 2020).…”

Section: The Potential Effect Of Curcumin In the Treatment Of Pulmonamentioning

confidence: 99%

Potential effects of curcumin in the treatment of COVID‐19 infection

Zahedipour

Hosseini

Sathyapalan

et al. 2020

Phytotherapy Research

291

245

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Coronavirus disease 2019 (COVID-19) outbreak is an ongoing pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with considerable mortality worldwide. The main clinical manifestation of COVID-19 is the presence of respiratory symptoms, but some patients develop severe cardiovascular and renal complications. There is an urgency to understand the mechanism by which this virus causes complications so as to develop treatment options. Curcumin, a natural polyphenolic compound, could be a potential treatment option for patients with coronavirus disease. In this study, we review some of the potential effects of curcumin such as inhibiting the entry of virus to the cell, inhibiting encapsulation of the virus and viral protease, as well as modulating various cellular signaling pathways. This review provides a basis for further research and development of clinical applications of curcumin for the treatment of newly emerged SARS-CoV-2.

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Section: The Potential Effect Of Curcumin In the Treatment Of Pulmonamentioning

confidence: 99%

Potential effects of curcumin in the treatment of COVID‐19 infection

Zahedipour

Hosseini

Sathyapalan

et al. 2020

Phytotherapy Research

291

245

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“…CURC, Figure 1b, the dietary pigment extracted from turmeric, is considered a very promising natural drug substance, although the poor water solubility of the compound at acidic pH values and its fast hydrolysis at neutral and basic ones represents an issue to be overcome prior to formulation of any CURC-based drug [1]. A constantly increasing number of publications have shown that CURC displays notable effects, not only as an anti-inflammatory compound [2,3,4] and a potent antioxidant [5,6,7,8], but also as a chemopreventive [9,10] and chemotherapeutic [9,11,12] agent. Moreover, it seems to have potential in the treatment of Alzheimer’s disease [13] and cystic fibrosis [14], as well as being considered a model substance for the treatment of HIV-infections and an immune-stimulating agent [15].…”

Section: Introductionmentioning

confidence: 99%

Elucidation of the Relationships between H-Bonding Patterns and Excited State Dynamics in Cyclovalone

et al. 2014

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Cyclovalone is a synthetic curcumin derivative in which the keto-enolic system is replaced by a cyclohexanone ring. This modification of the chemical structure might in principle result in an excited state that is more stable than that of curcumin, which in turn should produce an enhanced phototoxicity. Indeed, although curcumin exhibits photosensitized antibacterial activity, this compound is characterized by very fast excited-state dynamics which limit its efficacy as a photosensitizer. In previous works we showed that the main non-radiative decay pathway of keto-enolic curcuminoids is through excited-state transfer of the enolic proton to the keto-oxygen. Another effective deactivation pathway involves an intermolecular charge transfer mechanism occurring at the phenyl rings, made possible by intramolecular H-bonding between the methoxy and the hydroxyl substituent. In this paper we present UV-Vis and IR absorption spectra data with the aim of elucidating the intramolecular charge distribution of this compound and its solvation patterns in different environments, with particular focus on solute-solvent H-bonding features. Moreover, we OPEN ACCESSMolecules 2014, 19 13283 discuss steady state and time-resolved fluorescence data that aim at characterizing the excited-state dynamics of cyclovalone, and we compare its decay photophysics to that of curcumin. Finally, because during the characterization procedures we found evidence of very fast photodegradation of cyclovalone, its photostability in four organic solvents was studied by HPLC and the corresponding relative degradation rates were calculated.

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“…Besides the potential of curcumin to target critical steps of the viral replication cycle, previous studies have shown that curcumin can be effectively used to treat devastating outcomes of COVID-19 infection (Zahedipour et al 2020 ). For example, it can be used to treat COVID-19 associated pulmonary inflammation (Avasarala et al 2013 ; Ferreira et al 2015 ), pulmonary edema (Mathew et al 2015; Sagi et al 2014 ; Titto et al 2020 ) and pulmonary fibrosis (Chen et al 2008 ; Cutroneo et al 2007 ; Punithavathi et al 2000 , 2003 ; Tourkina et al 2004 ; Venkatesan et al 1995 ; Venkatesan 1999 ; Xu et al 2007 ), cardiovascular damage (Li et al 2017 ; Sahebkar and Henrotin 2016 ; Salabei and Conklin 2013 ), kidney damage (Sun et al 2017 ; Xu et al 2018 ), oxidative stress in viral infection (Dai et al 2018 ).…”

Section: Resultsmentioning

confidence: 99%

Enhanced curcumin loaded nanocellulose: a possible inhalable nanotherapeutic to treat COVID-19

et al. 2022

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Graphical abstract Nanocellulose/polyvinyl alcohol/curcumin (CNC/PVA/curcumin) nanoparticles with enhanced drug loading properties were developed by the dispersion of nanocellulose in curcumin/polyvinyl alcohol aqueous medium. Due to the physical and chemical nature of sulphuric acid hydrolyzed nanocellulose and the antiviral properties of curcumin, the possibility of using these nanoparticles as an inhalable nanotherapeutic for the treatment of coronavirus disease 2019 (COVID-19) is discussed. The adsorption of curcumin and PVA into nanocellulose, and the presence of anionic sulphate groups, which is important for the interaction with viral glycoproteins were confirmed by Fourier transform infrared (FTIR) spectroscopy. FESEM images showed that the diameter of nanocellulose ranged from 50 to 100 nm, which is closer to the diameter (60–140 nm) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The solubility of poorly water-soluble curcumin was increased from 40.58 ± 1.42 to 313.61 ± 1.05 mg/L with increasing the PVA concentration from 0.05 to 0.8% (w/v) in aqueous medium. This is a significant increase in the solubility compared to curcumin’s solubility in carboxymethyl cellulose medium in our previous study. The drug loading capacity increased by 22-fold with the addition of 0.8% PVA to the nanocellulose dispersed curcumin solution. The highest drug release increased from 1.25 ± 0.15 mg/L to 17.11 ± 0.22 mg/L with increasing the PVA concentration from 0 to 0.8% in the drug-loaded medium. Future studies of this material will be based on the antiviral efficacy against SARS-CoV-2 and cell cytotoxicity studies. Due to the particulate nature, morphology and size of SARS-CoV-2, nanoparticle-based strategies offer a strong approach to tackling this virus. Hence, we believe that the enhanced loading of curcumin in nanocellulose will provide a promising nano-based solution for the treatment of COVID-19.

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Prophylactic Administration of Curcumin Abates the Incidence of Hypobaric Hypoxia Induced Pulmonary Edema in Rats: A Molecular Approach

Abstract: Background and purpose: High Altitude Pulmonary Edema (HAPE) is a severe high altitude illness with serious pulmonary manifestations. The present study reports benefits of prophylactic administration of curcumin in prevention of hypoxia induced pulmonary edema.

Cited by 6 publications

References 61 publications

Potential effects of curcumin in the treatment of COVID‐19 infection

Potential effects of curcumin in the treatment of COVID‐19 infection

Elucidation of the Relationships between H-Bonding Patterns and Excited State Dynamics in Cyclovalone

Enhanced curcumin loaded nanocellulose: a possible inhalable nanotherapeutic to treat COVID-19

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