Prophylactic antibiotic usage in patients undergoing inguinal mesh hernioplasty — A clinical study

Thakur, Loveleen; Upadhyay, Shekhar; Peters, Nitin James; Saini, Navdeep; Deodhar, Michael

doi:10.1007/s12262-010-0051-2

Cited by 7 publications

(20 citation statements)

References 13 publications

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“…). Of 1683 original studies, 17 RCTs met the inclusion criteria, of which 13 had already been identified and included in previous meta‐analyses; four additional studies were identified, giving a total of 18 eligible RCTs.…”

Section: Resultsmentioning

confidence: 99%

“…Characteristics of the 18 RCTs are described in Tables and . Three and 15 trials respectively included herniorrhaphy and hernioplasty (prosthetic mesh). Four antibiotic classes were used in these studies: first‐generation cephalosporins, second‐generation cephalosporins, β‐lactam/β‐lactamase inhibitors and fluoroquinolones.…”

Section: Resultsmentioning

confidence: 99%

“…Most RCTs included mainly patients with an ASA fitness grade of I or II. The majority used CDC criteria for diagnosis of SSI; four studies used clinical signs and symptoms for diagnosis, including wound erythema, purulent drainage, opened wound, requirement for antibiotics, stitch abscess and wound breakdown/dehiscence.…”

Section: Resultsmentioning

confidence: 99%

“…Thirteen hernioplasty studies reported micro‐organism for SSIs, which were mainly S. aureus/Staphylococcus spp ,. followed by Escherichia coli , Pseudomonas aeruginosa/Pseudomonas spp .…”

Section: Resultsmentioning

confidence: 99%

“…All 15 RCTs that examined antibiotic prophylaxis for SSI in hernioplasty (5159 subjects) were included in a network meta‐analysis ( Table S3 , supporting information). All antibiotic contrasts were mapped in a network plot, in which five indirect active comparisons were estimated from the network: second‐ versus first‐generation cephalosporins, β‐lactam/β‐lactamase inhibitors versus first‐generation cephalosporins, β‐lactam/β‐lactamase inhibitors versus second‐generation cephalosporins, fluoroquinolones versus second‐generation cephalosporins and fluoroquinolones versus β‐lactam/β‐lactamase inhibitors ( Fig .…”

Section: Resultsmentioning

confidence: 99%

See 4 more Smart Citations

Network meta-analysis of antibiotic prophylaxis for prevention of surgical-site infection after groin hernia surgery

Boonchan

Wilasrusmee

McEvoy

et al. 2017

British Journal of Surgery

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BackgroundFirst‐generation cephalosporins (such as cefazolin) are recommended as antibiotic prophylaxis in groin hernia repair, but other broad‐spectrum antibiotics have also been prescribed in clinical practice. This was a systematic review and network meta‐analysis to compare the efficacy of different antibiotic classes for prevention of surgical‐site infection (SSI) after hernia repair.Methods RCTs were identified that compared efficacy of antibiotic prophylaxis on SSI after inguinal or femoral hernia repair from PubMed and Scopus databases up to March 2016. Data were extracted independently by two reviewers. Network meta‐analysis was applied to assess treatment efficacy. The probability of being the best antibiotic prophylaxis was estimated using surface under the cumulative ranking curve (SUCRA) analysis.ResultsFifteen RCTs (5159 patients) met the inclusion criteria. Interventions were first‐generation (7 RCTs, 1237 patients) and second‐generation (2 RCTs, 532) cephalosporins, β‐lactam/β‐lactamase inhibitors (6 RCTs, 619) and fluoroquinolones (2 RCTs, 581), with placebo as the most common comparator (14 RCTs, 2190). A network meta‐analysis showed that β‐lactam/β‐lactamase inhibitors and first‐generation cephalosporins were significantly superior to placebo, with a pooled risk ratio of 0·44 (95 per cent c.i. 0·25 to 0·75) and 0·62 (0·42 to 0·92) respectively. However, none of the antibiotic classes was significantly different from the others. SUCRA results indicated that β‐lactam/β‐lactamase inhibitors and first‐generation cephalosporins were ranked first and second respectively for best prophylaxis.Conclusionβ‐Lactam/β‐lactamase inhibitors followed by first‐generation cephalosporins ranked as the most effective SSI prophylaxis for adult patients undergoing groin hernia repair.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…Thirteen hernioplasty studies reported micro‐organism for SSIs, which were mainly S. aureus/Staphylococcus spp ,. followed by Escherichia coli , Pseudomonas aeruginosa/Pseudomonas spp .…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Network meta-analysis of antibiotic prophylaxis for prevention of surgical-site infection after groin hernia surgery

Boonchan

Wilasrusmee

McEvoy

et al. 2017

British Journal of Surgery

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Antibiotic prophylaxis for prevention of postoperative wound infection in adults undergoing open elective inguinal or femoral hernia repair

Orelio

Hessen

Sánchez-Manuel

et al. 2020

Cochrane Database of Systematic Reviews

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The role of prophylactic antibiotics in elective inguinal tension‐free hernia repair: A systematic review and meta‐analysis

Tian

Wang

Lei

et al. 2022

International Wound Journal

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Whether to use antibiotics to prevent surgical site infection in elective inguinal tension‐free hernia repair has been controversial. To systematically evaluate the effect of prophylactic antibiotic application in elective inguinal tension‐free hernia repair, we identified all published randomised controlled trials of the effect of prophylactic antibiotic application on elective inguinal tension‐free hernia repair were collected by computer retrieval from the China National Knowledge Infrastructure; VIP Database; Wanfang Database; China Biomedical Literature Database; and PubMed, EMBASE and Cochrane Library databases. Meta‐analysis was performed by RevMan 5.3 software. The meta‐analysis showed that the total incidence of surgical site infections [ P = 0.003] and the incidence of superficial surgical site infections [ P = 0.004] in the antibiotic group (AG) were lower than those in the non‐antibiotic group (NAG). There was no significant difference in the total incidence of postoperative infections [ P = 0.06], deep surgical site infections [ P = 0.26] and seroma [ P = 0.52] between the AG and the NAG. Based on current evidence, the application of prophylactic antibiotics in elective inguinal tension‐free hernia repair can prevent the total incidence of surgical site infections and that of superficial surgical site infections but cannot prevent the total incidence of postoperative infection events, incidence of deep surgical site infections and incidence of seroma.

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Prophylactic antibiotic usage in patients undergoing inguinal mesh hernioplasty — A clinical study

Abstract: Background There is ambiguity about the use of antibiotic prophylaxis in inguinal mesh hernioplasty. We have tried to assess the efficacy of antibiotic prophylaxis in this procedure.

Cited by 7 publications

References 13 publications

Network meta-analysis of antibiotic prophylaxis for prevention of surgical-site infection after groin hernia surgery

Network meta-analysis of antibiotic prophylaxis for prevention of surgical-site infection after groin hernia surgery

Antibiotic prophylaxis for prevention of postoperative wound infection in adults undergoing open elective inguinal or femoral hernia repair

The role of prophylactic antibiotics in elective inguinal tension‐free hernia repair: A systematic review and meta‐analysis

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