Prophylactic antibiotics and wound infections following laminectomy for lumber disc herniation

Abstract

The authors review 531 consecutive operations for lumbar disc herniation performed on 496 patients by one neurosurgeon to determine the effect of prophylactic antibiotics upon postoperative wound infections. In this retrospective analysis 16 instances of sepsis were found, 11 considered to be major and five minor. In the 128 cases in which no antibacterial agents were given, 11 major and 1 minor infection occurred. Four minor infections developed in the 402 occasions when antibiotics were given in the perioperative period. Men had a significantly greater risk of developing infection than women. These data suggest that pre- and postoperative antibiotic therapy directed at a narrow spectrum of microorganisms reduced the incidence of significant wound infections in patients undergoing laminectomy for lumbar disc herniation.

Antibacterial effect of royal jelly for preservation of implant-releated spinal infection in rat

“…in patients who undergo an implant surgery (1,6,8). The dead space in the surgical area, foreign bodies, necrotic tissue, and long-lasting surgical procedures are considered to be the factors increasing the risk of IRI (15).…”

Is postoperative Antimicrobial Prophylaxis Needed for the Management of Surgical Site Infection after Spinal Instrumentation Surgery?

“…AMP has been the standard management in lumbar spine surgery to prevent SSI since the report of Horwitz and Curtin in 1975 [2]. There have been many reports that the use of prophylactic antibiotics was effective to prevent SSI even in other spine surgeries [17][18][19][20][21][22][23][24].…”

“…The incidence of SSI is reported to be from less than 1% in decompressive surgery to 10% in instrumentation surgery [1][2][3][4][5]. The American Centers for Disease Control and Prevention (CDC) proposed a guideline for the prevention of SSI in 1999 [6].…”

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“…A incidência varia de 0,2% a 15% 24,26 . Em casos de artrodese e de instrumentação cirúrgica, a taxa de infecção pode chegar até a 8% 9 , e a 10,3% nas reoperações 21 . O espaço mais freqüentemente acometido é L4-L5, havendo descrição de discite em discos não manipulados na cirurgia 10 .…”