Prophylactic antibiotics for the prevention of preterm birth in women at risk: A meta‐analysis

Simcox, Rachael; Sin, Wing-To A.; Seed, Paul; Briley, Annette; Shennan, Andrew

doi:10.1111/j.1479-828x.2007.00759.x

Cited by 82 publications

(45 citation statements)

References 40 publications

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“…There are small trials assessing infections (McMahon et al, 2002), and no data on antibiotic treatment for prevention of preterm birth in twins. A recent meta-analysis concluded that antibiotic treatment does not reduce the risk of preterm birth in singleton pregnancies at risk (Simcox et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

Prediction of Spontaneous Preterm Delivery in Twin Pregnancies By Cervical Length at Mid-Gestation

et al. 2008

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The objective of our study was to evaluate the correlation of the cervical length at 20–25 weeks of gestation with the incidence of spontaneous preterm delivery in twins in a country with a high incidence of preterm delivery compared to other European countries. Cervical length was measured in 262 consecutive patients. Previous preterm delivery before 34 weeks of gestation, chorionicity, maternal age, body-mass-index, smoking habit and parity were recorded as risk factors for preterm delivery. Women who were symptomatic at 20–25 weeks and who delivered because of other reasons than spontaneous labour and preterm rupture of membranes or at term were excluded. The primary outcome was incidence of preterm birth before 34 weeks. Two hundred and twenty-three patients were analyzed. Thirty-two (14%) delivered before 34 weeks. There was a significant correlation between cervical length of less than 25 mm and spontaneous delivery before 34 weeks (50% vs. 13%,p= .007). In addition, logistic regression analysis found cervical length to be the only significant predictor of spontaneous delivery before 34 weeks (OR 1.084; 95% CI 1.015; 1.159;p= .017). We conclude that the risk of severe preterm delivery in twins is high. Cervical length at mid-gestation was the only predictor of delivery before 34 weeks.

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Section: Discussionmentioning

confidence: 99%

Prediction of Spontaneous Preterm Delivery in Twin Pregnancies By Cervical Length at Mid-Gestation

et al. 2008

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“…A causal link between infection and prematurity has been established, with at least 40% of all preterm births associated with infection and lower gestational age being linked to a higher frequency of intrauterine infection (Romero et al 2003). The majority of infections found in the uterine cavity associated with preterm labor are of vaginal origin (Epstein et al 2000, Jones et al 2009); however, antibiotics have been disappointing in preventing preterm birth (Simcox et al 2007). Alterations in AMP levels have been associated with infections that may lead to preterm birth as well as preterm labor and rupture of membranes.…”

Section: Amps and Preterm Labormentioning

confidence: 99%

Antimicrobial peptides and pregnancy

Frew¹,

Stock²

2011

Reproduction

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Antimicrobial peptides (AMPs) are small proteins produced by epithelial surfaces and inflammatory cells, which have broad-spectrum antimicrobial and immunomodulatory activities. They are known to be important in a number of infectious and inflammatory conditions and have been shown to be present in a number of sites throughout the female reproductive tract. Inflammation and infection are associated with a number of complications of pregnancy including preterm labor, and AMPs may play a key role in maintaining and protecting pregnancy. The aim of this review is to describe the expression and function of AMPs in the pregnant female reproductive tract and their relation to preterm labor.

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“…No significant association between antibiotic treatment and reduced rates of subsequent preterm birth were found (RR 1.03; 95% CI 0.86-1.24). 25 In 2008, a metaanalysis of 7 RCTs found no benefit in screening and treating women with low or moderate risk pregnancies. 26 Another 2008 meta-analysis assessed the effects of the use of anti-infectives.…”

Section: Anti-infective Medicationsmentioning

confidence: 99%

“…Neither metronidazole nor clindamycin were effective in reducing preterm birth rates. A later meta-analysis of 17 RCTs by Simcox et al 25 evaluated antibiotic treatment in pregnant women at risk abnormal flora (12 trials, e.g. trichomonas vaginalis, group B Streptococcus, ureaplasma urealyticum and Gardnerella vaginalis and/or bacterial vaginosis), previous preterm birth (3 trials), positive fetal fibronectin (2 trails).…”

Section: Anti-infective Medicationsmentioning

confidence: 99%

The effectiveness of medical interventions aimed at preventing preterm birth: A literature review

2011

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Prophylactic antibiotics for the prevention of preterm birth in women at risk: A meta‐analysis

Abstract: Treating women at risk of PTB with antibiotics does not reduce the risk of subsequent PTB.

Cited by 82 publications

References 40 publications

Prediction of Spontaneous Preterm Delivery in Twin Pregnancies By Cervical Length at Mid-Gestation

Prediction of Spontaneous Preterm Delivery in Twin Pregnancies By Cervical Length at Mid-Gestation

Antimicrobial peptides and pregnancy

The effectiveness of medical interventions aimed at preventing preterm birth: A literature review

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