2009
DOI: 10.1007/s00430-009-0135-4
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Prophylactic effect of bacteriophages on mice subjected to chemotherapy-induced immunosuppression and bone marrow transplant upon infection with Staphylococcus aureus

Abstract: Due to the increased resistance of bacteria to antibiotics, phage therapy may be an alternative to treat or prevent suppurative infections in immunocompromised patients. The authors' recent studies indicated that such an approach is particularly beneficial in immunosuppressed mice. A5/L bacteriophages, specific for the Staphylococcus aureus strain L, were tested for their ability to protect CBA mice subjected to myeloablative (busulfan) and immunosuppressive (cyclophosphamide) conditioning followed by a syngen… Show more

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Cited by 24 publications
(12 citation statements)
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“…The concentration of S. epidermidis used in our whole-blood model is high. However, this concentration is similar to lethal and sublethal doses of Staphylococci used in primate models of sepsis (30,31). During sepsis, bacteria often demonstrate massive growth within the first 12-24 h after entering the blood stream (32).…”
Section: S Epidermidismentioning
confidence: 74%
“…The concentration of S. epidermidis used in our whole-blood model is high. However, this concentration is similar to lethal and sublethal doses of Staphylococci used in primate models of sepsis (30,31). During sepsis, bacteria often demonstrate massive growth within the first 12-24 h after entering the blood stream (32).…”
Section: S Epidermidismentioning
confidence: 74%
“…It is currently being used in the food industry for the prevention of poultry infection (119), in the bacterial reduction of fresh produce (120), human cancer therapy (121), wound healing therapy (122), allergy prevention therapy (123), and in the control of opportunistic bacterial infections present in immuno-compromised mice (124).…”
Section: Bacteriophage (Phage) Therapymentioning
confidence: 99%
“…[31,37,39] Others appear to be effective in the treatment of staphylococcal infections in animals or are considered to be suitable candidates for phage therapy, based on in vitro experiments. [33,[40][41][42][43][44][45] Staphylococcal podoviruses that are obligatorily lytic are less common in bacteriophage collections. They have been classified under the subfamily Picovirinae, which is represented by one of the best-characterized bacterial viruses, Bacillus phage phi29.…”
Section: Staphylococcal Bacteriophagesmentioning
confidence: 99%