Prophylactic Effect of Diacerein against Cisplatin-Induced Nephrotoxicity in Rats

Diacerein ameliorates kidney injury induced by cisplatin in rats by activation of Nrf2/Ho-1 pathway and Bax down-regulation

“…This was revealed by histological findings of diacerein and cisplatin group as regenerative changes increased, but at 12th day from injection regenerative changes are more than these at the 7th day. These results are in agreement with the previous findings of Abdelaziz et al (2018) .…”

“…Diacerein is an anti-inflammatory analgesic medicine used to treat osteoarthritis. Rhein, an active metabolite of diacerein, has a renoprotective effect against cisplatin-induced acute kidney disease through its anti-inflammatory and antioxidant activities ( Abdel-Aziz et al, 2018 ). Diacerein decreased BUN, creatinine, and microalbuminuria levels in diacerein and cisplatin group after 7 and 12 days from the injection.…”

“…Rats were divided into 4 groups (N = 12). Normal group: Normal rats weren’t injected by anything, Diacerein group: Normal rats were supplemented with diacerein 50 mg/kg b.w./day by gastric gavage according to Abdel-Aziz et al (2018) , Cisplatin group: Rats injected in intraperitoneal by cisplatin 6 mg/kg b.w. for one time according to Liu et al (2017) , Cisplatin & Diacerein group: Rats injected in intraperitoneal by cisplatin 6 mg/kg b.w.…”

“…( Chueakula et al, 2018 ). Diacerein inhibits the nitric oxide production that explains its anti-inflammatory and anti-osteoarthritis properties ( Abdelaziz et al, 2018 ). Rhein, an active metabolite of diacerein, has nephroprotective, antioxidant, anti-inflammatory, hepatoprotective, anticancer, chondroprotective, antimicrobial, antidiabetic activities ( Zhou et al, 2015 , Guo et al, 2020 , de Oliveira et al, 2020 ) so this study targets to clarify diacerein effect on the cisplatin-induced renal injury in rats.…”