Prophylactic Effect of <i>Lactobacillus plantarum</i> YS4 on Oxazolone‐Induced Colitis in BALB/c Mice

Yi, Ruokun; Tan, Fang; Suo, Huayi; Li, Wenfeng; Zhou, Xianrong; Mu, Jianfei; Xie, Peng

doi:10.1155/2020/9048971

Cited by 5 publications

(2 citation statements)

References 30 publications

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“…The mechanisms of inflammation involve the imbalance of the Th1/Th2 network system. Th1 and Th2 cells secrete IL‐2 and IL‐10 cytokines, respectively, which are directly associated with the development and progression of UC (Fiocchi, 2004; Yi et al., 2020). Low content of IL‐2 and a high content of IL‐10 indicate that the extent of UC is intensified (Song et al., 2013).…”

Section: Discussionmentioning

confidence: 99%

Protective effect of Lactobacillus plantarum YS3 on dextran sulfate sodium‐induced colitis in C57BL/6J mice

Fan

Long

et al. 2021

J. Food Biochem.

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The protective effect of Lactobacillus plantarum YS3 (LP-YS3) on ulcerative colitis (UC) was assessed using a mouse model of dextran sodium sulfate (DSS)-induced colitis. Different concentrations of LP-YS4 were administered to the experimental mice by daily gavage. Several inflammatory and biochemical indices, such as interleukin-2 (IL-2), interleukin-10 (IL-10), interleukin-6 (IL-6), interleukin-1 beta (IL-1β), tumor necrosis factor-alpha (TNFα), glutathione (GSH), malondialdehyde (MDA), myeloperoxidase (MPO), and nitric oxide (NO), were examined in mouse serum and colon tissue. The mRNA and protein expression levels of c-Kit, CXC chemokine receptor type 2 (CXCR2), interleukin-8 (IL-8), and stem cell factor (SCF) in mouse colon tissue were assessed using Western blot and quantitative polymerase chain reaction (qPCR) assays. The findings indicated that LP-YS3 remarkably decreased the disease activity index (DAI) of UC mice (p < .05), inhibited colon length shortening induced by UC, and elevated the value of colon weight/length ratio. LP-YS3 could also markedly reduce (p < .05) the activities of MDA, MPO, and NO; while an increase in the GSH content in the colonic tissue of UC mice. Moreover, LP-YS3 remarkably increased (p < .05) the serum level of IL-2 in UC mice, while reduced those of IL-10, IL-6, IL-1β, TNFα cytokines. qPCR data revealed that LP-YS3 could markedly upregulate the expression levels of c-Kit and SCF, while downregulate those of CXCR2 and IL-8 in the colonic tissue of UC mice (p < .05). LP-YS3 exerted an outstanding protective effect on DSS-induced colitis in C57BL/6J mice, especially at higher concentrations. Practical applications Lactobacillus plantarum YS3 is a newly isolated and identified lactic acid bacteria. This study confirmed that L. plantarum YS3 can inhibit colitis and has good probiotic potential, which needs further development and utilization.

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Section: Discussionmentioning

confidence: 99%

Protective effect of Lactobacillus plantarum YS3 on dextran sulfate sodium‐induced colitis in C57BL/6J mice

Fan

Long

et al. 2021

J. Food Biochem.

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“…It has been reported that the mechanism responsible for producing the scratching in mice after repeated application with oxazolone resembles that of the itching in patients with AD ( 12 ). Oxazolone is also used to induce colitis and respiratory allergy ( 13 , 14 ). DNFB is an decoupling agent, first used to induce typical skin sensitization of the contact type in guinea pigs ( 15 ).…”

Section: Introductionmentioning

confidence: 99%

Comparative Study on Different Skin Pruritus Mouse Models

et al. 2021

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The animal model is an important tool to study the mechanism of disease formation. Different animal models of pruritus have been adopted based on the purpose of researchers in the study of the itching mechanism. Although the symptoms of various models are quite different, scratching behavior is a key indicator. Therefore, it is necessary to find an animal model that can quickly induce animal scratching and maintain the stability of scratching behavior. In this study, we compared animal models of pruritus induced by four substances and found that the scratching behavior of mice induced by urushiol not only reached the plateau stage quickly but also showed more stability in the plateau phase than that induced by 2,4-dinitrofluorobenzene, oxazolone, and imiquimod. Meanwhile, in the animal model induced by urushiol, the changes of epidermal thickening and inflammatory cell aggregation were also more obvious. In addition, pruritus induced by urushiol is prevalent all over the world, especially in the United States and Europe, involving outdoor groups such as firefighters, forest loggers, and farmers. Therefore, we believe that the urushiol-induced animal model is an ideal choice for the study of the itch formation mechanism and the development of antipruritic drugs.

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Structure and regulatory mechanisms of food‐derived peptides in inflammatory bowel disease: A review

Qiu,

Wang,

Liu

et al. 2024

Food Science & Nutrition

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The number of patients with inflammatory bowel disease (IBD) is increasing worldwide. Since IBD is a chronic disease that seriously affects patients' life quality, preventing and alleviating IBD with natural and less side effect substances has become a research hotspot. Food‐derived bioactive peptides have been an attractive research focus due to their high efficiency and low toxicity. This paper comprehensively summarizes food‐derived peptides with intestinal health effects, focusing on peptide sequences with IBD‐regulatory effects and emphasizing the effects of their structure and physicochemical properties such as peptide length, amino acid composition, and net charge on their function. We also analyzed its regulatory mechanisms, mainly in 5 aspects: modulating the intestinal microbiota, decreasing intestinal epithelial permeability, increasing antioxidant ability, regulating the expression of inflammatory cytokines, and targeting signaling pathways. This review will help establish novel, efficient screening methods for IBD‐regulatory peptides and contribute to further research and discovery of them.

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Prophylactic Effect of Lactobacillus plantarum YS4 on Oxazolone‐Induced Colitis in BALB/c Mice

Cited by 5 publications

References 30 publications

Protective effect of Lactobacillus plantarum YS3 on dextran sulfate sodium‐induced colitis in C57BL/6J mice

Protective effect of Lactobacillus plantarum YS3 on dextran sulfate sodium‐induced colitis in C57BL/6J mice

Comparative Study on Different Skin Pruritus Mouse Models

Structure and regulatory mechanisms of food‐derived peptides in inflammatory bowel disease: A review

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